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Protein

Transcriptional activator protein

Gene

C2

Organism
Tomato leaf curl Karnataka virus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Strong activator of the late viral genes promoters. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Also suppresses the host basal defense by interacting with and inhibiting SNF1 kinase, a key regulator of cell metabolism implicated in innate antiviral defense. Determines pathogenicity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation, Suppressor of RNA silencingUniRule annotation

Keywords - Biological processi

Host-virus interactionUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator proteinUniRule annotation
Short name:
TrAPUniRule annotation
Gene namesi
Name:C2Imported
OrganismiTomato leaf curl Karnataka virusImported
Taxonomic identifieri220932 [NCBI]
Taxonomic lineageiVirusesssDNA virusesGeminiviridaeBegomovirus

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasmUniRule annotation, Host nucleusUniRule annotation

Interactioni

Subunit structurei

Monomer. Homodimer. Homooligomer. Self-interaction correlates with nuclear localization and efficient activation of transcription.UniRule annotation

Family & Domainsi

Domaini

The zinc finger and the transactivation region are involved in PTGS suppression.UniRule annotation

Sequence similaritiesi

Belongs to the geminiviridae transcriptional activator protein family.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Family and domain databases

InterProiIPR000942. Gemini_AL2.
[Graphical view]
PfamiPF01440. Gemini_AL2. 1 hit.
[Graphical view]
PRINTSiPR00230. GEMCOATAL2.
ProDomiPD001117. Gemini_AL2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q98742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPSSPPRAH STQVPIKVQH RLAKKGTRRR RVDLPCGCSY FIALACHDHG
60 70 80 90 100
FTHRGTHHCS SSREWRVYLG DSKSPIFQDN RASQPAIPDE PRHHHRPSTV
110 120 130
QSQPEESVGD TQMFPSLPNL DDLTASDWSF LKGI
Length:134
Mass (Da):15,174
Last modified:February 1, 1997 - v1
Checksum:i7D46F3F0E6F36AD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38239 Genomic DNA. Translation: AAB08931.1.
KP178731 Genomic DNA. Translation: AJW80925.1.
RefSeqiNP_632011.1. NC_003897.1.

Genome annotation databases

GeneIDi944511.
KEGGivg:944511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38239 Genomic DNA. Translation: AAB08931.1.
KP178731 Genomic DNA. Translation: AJW80925.1.
RefSeqiNP_632011.1. NC_003897.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi944511.
KEGGivg:944511.

Family and domain databases

InterProiIPR000942. Gemini_AL2.
[Graphical view]
PfamiPF01440. Gemini_AL2. 1 hit.
[Graphical view]
PRINTSiPR00230. GEMCOATAL2.
ProDomiPD001117. Gemini_AL2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "Tomato leaf curl virus from Southern India: A monopartite whitefly-transmitted geminivirus."
    Chatchawankanphanich O., Chiang B.-T., Green S.K., Singh S.J., Mehta P., Maxwell D.P.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bangalore IIImported.
  2. "Molecular characterization of Tomato leaf curl Karnataka virus infecting tomato in India."
    Swarnalatha P., Venkatravanappa V., Jalali S., Krishna Reddy M.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TC120Imported.

Entry informationi

Entry nameiQ98742_9GEMI
AccessioniPrimary (citable) accession number: Q98742
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.