Q985W2 (KHSE_RHILO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	mlr7503

Organism

Rhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

266835 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Homoserine kinase HAMAP MF_00301		PRO_0000172196

Sequences

	Sequence		Length	Mass (Da)
	Q985W2 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 837C4C30D7E26D0C	FASTA	320	35,152
	10 20 30 40 50 60 MAVYTDVAEG ELGAFLKHYP VGDLLSYKGI AEGTENSNFL LHTSSGSYIL TLYEKRVEKA 70 80 90 100 110 120 DLPFFLGLMG HLANKGVSCP LPVTAHDGSV IGTLAGRPAV IITFLEGLSL RRPTATHCAE 130 140 150 160 170 180 VGKALAALHL AGADFPMTRP NALAIDGWRK LWNAARDRAD EVEPGLAAEV DADFADFERN 190 200 210 220 230 240 WPRGLPAGII HADLFPDNVF FLGEKLSGLI DFYFACDDLY AYDVATCLNA WCFEKDFSFN 250 260 270 280 290 300 LTKGKALLAG YQSVRPLSGE EKAALPMLSR GSALRFMLTR LYDWLTVSDG GLVMKRDPTE 310 320 YIRRMRFHRA IKSASEYGLA

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000012 Genomic DNA. Translation: BAB53591.1.
RefSeq	NP_107805.1. NC_002678.2.
3D structure databases
ProteinModelPortal	Q985W2.
SMR	Q985W2. Positions 5-320.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1230460.
GenomeReviews	Gene locus mlr7503 in contig BA000012_GR.
KEGG	mlo:mlr7503.
NMPDR	fig|266835.1.peg.5906.
PATRIC	22486229. VBIMesLot2464_5994.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_RHILO

Accession

Primary (citable) accession number: Q985W2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program