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Protein

Glucose-1-phosphate adenylyltransferase

Gene

glgC

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.UniRule annotation

Catalytic activityi

ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.UniRule annotation

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108Alpha-D-glucose 1-phosphateUniRule annotation1
Binding sitei173Alpha-D-glucose 1-phosphate; via amide nitrogenUniRule annotation1
Binding sitei206Alpha-D-glucose 1-phosphate; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00164

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-1-phosphate adenylyltransferaseUniRule annotation (EC:2.7.7.27UniRule annotation)
Alternative name(s):
ADP-glucose pyrophosphorylaseUniRule annotation
Short name:
ADPGlc PPaseUniRule annotation
ADP-glucose synthaseUniRule annotation
Gene namesi
Name:glgCUniRule annotation
Ordered Locus Names:mlr7588
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001953171 – 421Glucose-1-phosphate adenylyltransferaseAdd BLAST421

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mlr7588

Structurei

3D structure databases

ProteinModelPortaliQ985P3
SMRiQ985P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni188 – 189Alpha-D-glucose 1-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QQ4 Bacteria
COG0448 LUCA
HOGENOMiHOG000278607
KOiK00975
OMAiHCVLGVR
OrthoDBiPOG091H09L2

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00624 GlgC, 1 hit
InterProiView protein in InterPro
IPR011831 ADP-Glc_PPase
IPR005836 ADP_Glu_pyroP_CS
IPR023049 GlgC_bac
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
PfamiView protein in Pfam
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR02091 glgC, 1 hit
PROSITEiView protein in PROSITE
PS00808 ADP_GLC_PYROPHOSPH_1, 1 hit
PS00809 ADP_GLC_PYROPHOSPH_2, 1 hit
PS00810 ADP_GLC_PYROPHOSPH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q985P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLKRTQPL ARDAMAYVLA GGRGSRLKEL TDRRAKPAVY FGGKTRIIDF
60 70 80 90 100
ALSNALNSGI RRLGVATQYK AHSLIRHLQR GWNFLRPERN ESFDILPASQ
110 120 130 140 150
RVSETQWYEG TADAVYQNID IIEAYGPEYM VILAGDHIYK MDYEMMLRQH
160 170 180 190 200
VDANADVTVG CLEVPRMEAT GFGVMHVDAK DNIIAFVEKP ADPPGIPGNP
210 220 230 240 250
DFALASMGIY VFKTKFLMEQ LRRDAAEPGS SRDFGKDIIP YIVQHGKAIA
260 270 280 290 300
HRFTKSCVRS TAENEAYWRD VGTVDAYWEA NIDLTDITPE LDLYDRDWPI
310 320 330 340 350
WTYAELKPPA KFVHDEDGRR GSAVSSLVSG DCIVSGATLK KSLIFTGARI
360 370 380 390 400
NSYSTLEEVV MLPDVHVGRN AKLKRVVIDH GVRIPEGLVV GEDPALDAKR
410 420
FRVSEKGICL ITQDMINKLG L
Length:421
Mass (Da):47,037
Last modified:October 1, 2001 - v1
Checksum:i6DD17FC327A876D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145M → L in AAK58595 (Ref. 1) Curated1
Sequence conflicti154N → G in AAK58595 (Ref. 1) Curated1
Sequence conflicti201D → E in AAK58595 (Ref. 1) Curated1
Sequence conflicti227E → D in AAK58595 (Ref. 1) Curated1
Sequence conflicti262A → M in AAK58595 (Ref. 1) Curated1
Sequence conflicti287I → V in AAK58595 (Ref. 1) Curated1
Sequence conflicti338T → S in AAK58595 (Ref. 1) Curated1
Sequence conflicti355T → A in AAK58595 (Ref. 1) Curated1
Sequence conflicti395A → V in AAK58595 (Ref. 1) Curated1
Sequence conflicti411I → V in AAK58595 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268969 Genomic DNA Translation: AAK58595.1
BA000012 Genomic DNA Translation: BAB54019.1
RefSeqiWP_010914967.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB54019; BAB54019; BAB54019
KEGGimlo:mlr7588

Similar proteinsi

Entry informationi

Entry nameiGLGC_RHILO
AccessioniPrimary (citable) accession number: Q985P3
Secondary accession number(s): Q93QE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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