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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Potassium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi93Potassium 1UniRule annotation1
Active sitei161Charge relay systemUniRule annotation1
Binding sitei208NAD/NADP; via amide nitrogenUniRule annotation1
Active sitei249Proton acceptorUniRule annotation1
Binding sitei283NAD/NADPUniRule annotation1
Binding sitei384NAD/NADPUniRule annotation1
Metal bindingi454Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi457Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei461Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi149 – 152NAD/NADPUniRule annotation4
Nucleotide bindingi175 – 178NAD/NADPUniRule annotation4
Nucleotide bindingi227 – 232NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
Ordered Locus Names:mll7608
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000565521 – 487NAD/NADP-dependent betaine aldehyde dehydrogenaseAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Proteomic databases

PRIDEiQ985M6

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll7608

Structurei

3D structure databases

ProteinModelPortaliQ985M6
SMRiQ985M6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271505
KOiK00130
OMAiSFGYTRR
OrthoDBiPOG091H05FS

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00804 BADH, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01804 BADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q985M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAQPTASHY VNGRYIDDEQ GAPLPVIYPA TGETIAMLRS ATPNVLELAI
60 70 80 90 100
EAARAAQPAW ARLKPVERGR ILRRAADILR ARNADLARIE TLDTGKAIQE
110 120 130 140 150
TLVADAPSAA DCLEYFGGAV AAYNGEAVDL GGPFAYTRRE ALGVCVGIGA
160 170 180 190 200
WNYPIQIAGW KSAPALAMGN AMVFKPSENT PLSALALAEI YSEAGLPDGL
210 220 230 240 250
FNVVQGYGDV GAGLVGHDVV AKVSVTGSVP TGRKVLSLAG SKMKHATMEL
260 270 280 290 300
GGKSPLIVFD DADIENAIGG AMLGNFYSTG QICSNGTRVF VQSGIHDRFV
310 320 330 340 350
ERLVERTKKI RIGNPLDPET QMGPLVSKAQ HEKVVGYIGI GKQDGAVLAC
360 370 380 390 400
GGNVPSLQGF DGGFFVEPTV FTGVTDTMRI AREEIFGPVM SVLKFDGEDE
410 420 430 440 450
VIDRANDTEF GLAAGVFTRD LPRAHRVIAE LQAGTCWINA YNLTPVEIPF
460 470 480
GGFKQSGIGR ENSLAALALY SQLKSIYVET GDVASPY
Length:487
Mass (Da):51,678
Last modified:October 1, 2001 - v1
Checksum:i74CE4AC1F6AC0F5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB54036.1
RefSeqiWP_010914984.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB54036; BAB54036; BAB54036
KEGGimlo:mll7608

Similar proteinsi

Entry informationi

Entry nameiBETB_RHILO
AccessioniPrimary (citable) accession number: Q985M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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