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Q985M6

- BETB_RHILO

UniProt

Q985M6 - BETB_RHILO

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271Potassium 1; via carbonyl oxygenUniRule annotation
    Metal bindingi93 – 931Potassium 1UniRule annotation
    Active sitei161 – 1611Charge relay systemUniRule annotation
    Binding sitei208 – 2081NAD/NADP; via amide nitrogenUniRule annotation
    Active sitei249 – 2491Proton acceptorUniRule annotation
    Binding sitei283 – 2831NAD/NADPUniRule annotation
    Binding sitei384 – 3841NAD/NADPUniRule annotation
    Metal bindingi454 – 4541Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi457 – 4571Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei461 – 4611Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi149 – 1524NAD/NADPUniRule annotation
    Nucleotide bindingi175 – 1784NAD/NADPUniRule annotation
    Nucleotide bindingi227 – 2326NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-6044-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:mll7608
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_0000056552Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei283 – 2831Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi266835.mll7608.

    Structurei

    3D structure databases

    ProteinModelPortaliQ985M6.
    SMRiQ985M6. Positions 7-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiCEHQLVA.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q985M6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAQPTASHY VNGRYIDDEQ GAPLPVIYPA TGETIAMLRS ATPNVLELAI    50
    EAARAAQPAW ARLKPVERGR ILRRAADILR ARNADLARIE TLDTGKAIQE 100
    TLVADAPSAA DCLEYFGGAV AAYNGEAVDL GGPFAYTRRE ALGVCVGIGA 150
    WNYPIQIAGW KSAPALAMGN AMVFKPSENT PLSALALAEI YSEAGLPDGL 200
    FNVVQGYGDV GAGLVGHDVV AKVSVTGSVP TGRKVLSLAG SKMKHATMEL 250
    GGKSPLIVFD DADIENAIGG AMLGNFYSTG QICSNGTRVF VQSGIHDRFV 300
    ERLVERTKKI RIGNPLDPET QMGPLVSKAQ HEKVVGYIGI GKQDGAVLAC 350
    GGNVPSLQGF DGGFFVEPTV FTGVTDTMRI AREEIFGPVM SVLKFDGEDE 400
    VIDRANDTEF GLAAGVFTRD LPRAHRVIAE LQAGTCWINA YNLTPVEIPF 450
    GGFKQSGIGR ENSLAALALY SQLKSIYVET GDVASPY 487
    Length:487
    Mass (Da):51,678
    Last modified:October 1, 2001 - v1
    Checksum:i74CE4AC1F6AC0F5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB54036.1.
    RefSeqiNP_107891.1. NC_002678.2.
    WP_010914984.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB54036; BAB54036; BAB54036.
    GeneIDi1230546.
    KEGGimlo:mll7608.
    PATRICi22486419. VBIMesLot2464_6087.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB54036.1 .
    RefSeqi NP_107891.1. NC_002678.2.
    WP_010914984.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q985M6.
    SMRi Q985M6. Positions 7-487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mll7608.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB54036 ; BAB54036 ; BAB54036 .
    GeneIDi 1230546.
    KEGGi mlo:mll7608.
    PATRICi 22486419. VBIMesLot2464_6087.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi CEHQLVA.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci MLOT266835:GJ9L-6044-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiBETB_RHILO
    AccessioniPrimary (citable) accession number: Q985M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3