Reviewed, UniProtKB/Swiss-Prot Q985M6 (BETB_RHILO)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	mll7608

Organism

Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP]

Taxonomic identifier

381 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056552
Regions
	Nucleotide binding	227 – 232	6	NAD By similarity
Sites
	Active site	249	1	By similarity
	Active site	283	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q985M6-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 74CE4AC1F6AC0F5E	FASTA	487	51,678
	10 20 30 40 50 60 MRAQPTASHY VNGRYIDDEQ GAPLPVIYPA TGETIAMLRS ATPNVLELAI EAARAAQPAW 70 80 90 100 110 120 ARLKPVERGR ILRRAADILR ARNADLARIE TLDTGKAIQE TLVADAPSAA DCLEYFGGAV 130 140 150 160 170 180 AAYNGEAVDL GGPFAYTRRE ALGVCVGIGA WNYPIQIAGW KSAPALAMGN AMVFKPSENT 190 200 210 220 230 240 PLSALALAEI YSEAGLPDGL FNVVQGYGDV GAGLVGHDVV AKVSVTGSVP TGRKVLSLAG 250 260 270 280 290 300 SKMKHATMEL GGKSPLIVFD DADIENAIGG AMLGNFYSTG QICSNGTRVF VQSGIHDRFV 310 320 330 340 350 360 ERLVERTKKI RIGNPLDPET QMGPLVSKAQ HEKVVGYIGI GKQDGAVLAC GGNVPSLQGF 370 380 390 400 410 420 DGGFFVEPTV FTGVTDTMRI AREEIFGPVM SVLKFDGEDE VIDRANDTEF GLAAGVFTRD 430 440 450 460 470 480 LPRAHRVIAE LQAGTCWINA YNLTPVEIPF GGFKQSGIGR ENSLAALALY SQLKSIYVET GDVASPY

References

[1]

"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S. DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000012 Genomic DNA. Translation: BAB54036.1.
RefSeq	NP_107891.1.
3D structure databases
HSSP	HSSP built from PDB template 1A4S based on UniProtKB P56533.
ModBase	Search...
Genome annotation databases
GeneID	1230546.
GenomeReviews	Gene locus mll7608 in contig BA000012_GR.
KEGG	mlo:mll7608.
NMPDR	fig|266835.1.peg.5992.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q985M6.
OMA	Q985M6. VFKPSEN.
Enzyme and pathway databases
BRENDA	1.2.1.8. 3315.
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_RHILO

Accession

Primary (citable) accession number: Q985M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)