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Q985M6

- BETB_RHILO

UniProt

Q985M6 - BETB_RHILO

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, mll7608
Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Potassium 1; via carbonyl oxygen By similarity
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei161 – 1611Charge relay system By similarity
Binding sitei208 – 2081NAD/NADP; via amide nitrogen By similarity
Active sitei249 – 2491Proton acceptor By similarity
Binding sitei283 – 2831NAD/NADP By similarity
Binding sitei384 – 3841NAD/NADP By similarity
Metal bindingi454 – 4541Potassium 2; via carbonyl oxygen By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Active sitei461 – 4611Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi149 – 1524NAD/NADP By similarity
Nucleotide bindingi175 – 1784NAD/NADP By similarity
Nucleotide bindingi227 – 2326NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-6044-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:mll7608
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_0000056552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll7608.

Structurei

3D structure databases

ProteinModelPortaliQ985M6.
SMRiQ985M6. Positions 7-487.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCEHQLVA.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q985M6-1 [UniParc]FASTAAdd to Basket

« Hide

MRAQPTASHY VNGRYIDDEQ GAPLPVIYPA TGETIAMLRS ATPNVLELAI    50
EAARAAQPAW ARLKPVERGR ILRRAADILR ARNADLARIE TLDTGKAIQE 100
TLVADAPSAA DCLEYFGGAV AAYNGEAVDL GGPFAYTRRE ALGVCVGIGA 150
WNYPIQIAGW KSAPALAMGN AMVFKPSENT PLSALALAEI YSEAGLPDGL 200
FNVVQGYGDV GAGLVGHDVV AKVSVTGSVP TGRKVLSLAG SKMKHATMEL 250
GGKSPLIVFD DADIENAIGG AMLGNFYSTG QICSNGTRVF VQSGIHDRFV 300
ERLVERTKKI RIGNPLDPET QMGPLVSKAQ HEKVVGYIGI GKQDGAVLAC 350
GGNVPSLQGF DGGFFVEPTV FTGVTDTMRI AREEIFGPVM SVLKFDGEDE 400
VIDRANDTEF GLAAGVFTRD LPRAHRVIAE LQAGTCWINA YNLTPVEIPF 450
GGFKQSGIGR ENSLAALALY SQLKSIYVET GDVASPY 487
Length:487
Mass (Da):51,678
Last modified:October 1, 2001 - v1
Checksum:i74CE4AC1F6AC0F5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB54036.1.
RefSeqiNP_107891.1. NC_002678.2.
WP_010914984.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB54036; BAB54036; BAB54036.
GeneIDi1230546.
KEGGimlo:mll7608.
PATRICi22486419. VBIMesLot2464_6087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB54036.1 .
RefSeqi NP_107891.1. NC_002678.2.
WP_010914984.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q985M6.
SMRi Q985M6. Positions 7-487.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266835.mll7608.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB54036 ; BAB54036 ; BAB54036 .
GeneIDi 1230546.
KEGGi mlo:mll7608.
PATRICi 22486419. VBIMesLot2464_6087.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CEHQLVA.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci MLOT266835:GJ9L-6044-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiBETB_RHILO
AccessioniPrimary (citable) accession number: Q985M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2001
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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