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Q985M6 (BETB_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:mll7608
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium ›

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_0000056552

Regions

Nucleotide binding227 – 2326NAD By similarity

Sites

Active site2491 By similarity
Active site2831 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q985M6 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 74CE4AC1F6AC0F5E

FASTA48751,678
        10         20         30         40         50         60 
MRAQPTASHY VNGRYIDDEQ GAPLPVIYPA TGETIAMLRS ATPNVLELAI EAARAAQPAW 

        70         80         90        100        110        120 
ARLKPVERGR ILRRAADILR ARNADLARIE TLDTGKAIQE TLVADAPSAA DCLEYFGGAV 

       130        140        150        160        170        180 
AAYNGEAVDL GGPFAYTRRE ALGVCVGIGA WNYPIQIAGW KSAPALAMGN AMVFKPSENT 

       190        200        210        220        230        240 
PLSALALAEI YSEAGLPDGL FNVVQGYGDV GAGLVGHDVV AKVSVTGSVP TGRKVLSLAG 

       250        260        270        280        290        300 
SKMKHATMEL GGKSPLIVFD DADIENAIGG AMLGNFYSTG QICSNGTRVF VQSGIHDRFV 

       310        320        330        340        350        360 
ERLVERTKKI RIGNPLDPET QMGPLVSKAQ HEKVVGYIGI GKQDGAVLAC GGNVPSLQGF 

       370        380        390        400        410        420 
DGGFFVEPTV FTGVTDTMRI AREEIFGPVM SVLKFDGEDE VIDRANDTEF GLAAGVFTRD 

       430        440        450        460        470        480 
LPRAHRVIAE LQAGTCWINA YNLTPVEIPF GGFKQSGIGR ENSLAALALY SQLKSIYVET 


GDVASPY

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000012 Genomic DNA. Translation: BAB54036.1.
RefSeqNP_107891.1. NC_002678.2.

3D structure databases

ProteinModelPortalQ985M6.
SMRQ985M6. Positions 7-487.
ModBaseSearch...

Protein-protein interaction databases

STRING266835.mll7608.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB54036; BAB54036; BAB54036.
GeneID1230546.
KEGGmlo:mll7608.
PATRIC22486419. VBIMesLot2464_6087.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAIGRENSL.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-6044-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_RHILO
AccessionPrimary (citable) accession number: Q985M6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2001
Last modified: May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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