ID   BETA_RHILO              Reviewed;         550 AA.
AC   Q985M5;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=mll7609;
OS   Rhizobium loti (Mesorhizobium loti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=381;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MAFF303099;
RX   MEDLINE=21082930; PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T.,
RA   Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Mochizuki Y., Nakayama S., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; BA000012; BAB54037.1; -; Genomic_DNA.
DR   RefSeq; NP_107892.1; -.
DR   GeneID; 1230547; -.
DR   GenomeReviews; BA000012_GR; mll7609.
DR   KEGG; mlo:mll7609; -.
DR   NMPDR; fig|266835.1.peg.5993; -.
DR   HOGENOM; Q985M5; -.
DR   OMA; Q985M5; HMTVKNG.
DR   BRENDA; 1.1.99.1; 3315.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    550       Choline dehydrogenase.
FT                                /FTId=PRO_0000205593.
FT   NP_BIND       5     34       FAD (Probable).
FT   ACT_SITE    466    466       By similarity.
SQ   SEQUENCE   550 AA;  60125 MW;  B3FC4F94EA6B5E21 CRC64;
     MLEADFVIIG SGSAGSAMAY RLSEDGKHSV IVIEFGGSDI GPLIQMPSAL SIPLNMSLYD
     WGFASEPEPH LGGRVLATPR GKVIGGSSSI NGMVYVRGHA RDFDHWAEEG ATGWGFADVL
     PYFKRMEDND GGEDGWRGHG GPLHVQRGSR KNPLYGAFVE AGRQAGFELT DDYNGSKQEG
     FGPMEQTISG GRRWSAASAY LKPALKRKNV SLVKGFARRV IIENQRAIGV EIEAHKQIQV
     VKARREVIVA ASSINSPKIL MLSGIGPAEH LRENGIAVVA DRPGVGRNLQ DHMELYIQQE
     STKPITLNSV LNPFSKALIG AQWLFFKSGL GATNHFEAAA FVRSRAGVDY PDIQYHFIPA
     AVRYDGKAAA KSHGFQAHVG PMRSKSRGSV TLRSPDPKAK PVIRFNYMSH PDDWTEFRHC
     IRLTREIFGQ SAFDAFRGQE ISPGSHVQSD DDLDVFIRDH AESAYHPCGT CKMGRADDVT
     SVVDPECRVI GVDGLRVADS SIFPRVTNGN LNAPSIMTGE KASDHILGRT PLAPSNQEPW
     INPRWQVSDR
//