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Q985M5

- BETA_RHILO

UniProt

Q985M5 - BETA_RHILO

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei466 – 4661UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi5 – 3430FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-6045-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:mll7609
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Oxygen-dependent choline dehydrogenasePRO_0000205593Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266835.mll7609.

Structurei

3D structure databases

ProteinModelPortaliQ985M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiLTDDYNG.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q985M5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEADFVIIG SGSAGSAMAY RLSEDGKHSV IVIEFGGSDI GPLIQMPSAL
60 70 80 90 100
SIPLNMSLYD WGFASEPEPH LGGRVLATPR GKVIGGSSSI NGMVYVRGHA
110 120 130 140 150
RDFDHWAEEG ATGWGFADVL PYFKRMEDND GGEDGWRGHG GPLHVQRGSR
160 170 180 190 200
KNPLYGAFVE AGRQAGFELT DDYNGSKQEG FGPMEQTISG GRRWSAASAY
210 220 230 240 250
LKPALKRKNV SLVKGFARRV IIENQRAIGV EIEAHKQIQV VKARREVIVA
260 270 280 290 300
ASSINSPKIL MLSGIGPAEH LRENGIAVVA DRPGVGRNLQ DHMELYIQQE
310 320 330 340 350
STKPITLNSV LNPFSKALIG AQWLFFKSGL GATNHFEAAA FVRSRAGVDY
360 370 380 390 400
PDIQYHFIPA AVRYDGKAAA KSHGFQAHVG PMRSKSRGSV TLRSPDPKAK
410 420 430 440 450
PVIRFNYMSH PDDWTEFRHC IRLTREIFGQ SAFDAFRGQE ISPGSHVQSD
460 470 480 490 500
DDLDVFIRDH AESAYHPCGT CKMGRADDVT SVVDPECRVI GVDGLRVADS
510 520 530 540 550
SIFPRVTNGN LNAPSIMTGE KASDHILGRT PLAPSNQEPW INPRWQVSDR
Length:550
Mass (Da):60,125
Last modified:October 1, 2001 - v1
Checksum:iB3FC4F94EA6B5E21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB54037.1.
RefSeqiNP_107892.1. NC_002678.2.
WP_010914985.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB54037; BAB54037; BAB54037.
GeneIDi1230547.
KEGGimlo:mll7609.
PATRICi22486421. VBIMesLot2464_6088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB54037.1 .
RefSeqi NP_107892.1. NC_002678.2.
WP_010914985.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q985M5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266835.mll7609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB54037 ; BAB54037 ; BAB54037 .
GeneIDi 1230547.
KEGGi mlo:mll7609.
PATRICi 22486421. VBIMesLot2464_6088.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi LTDDYNG.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci MLOT266835:GJ9L-6045-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiBETA_RHILO
AccessioniPrimary (citable) accession number: Q985M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3