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Q985M5

- BETA_RHILO

UniProt

Q985M5 - BETA_RHILO

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei466 – 4661UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi5 – 3430FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-6045-MONOMER.
    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:mll7609
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Oxygen-dependent choline dehydrogenasePRO_0000205593Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mll7609.

    Structurei

    3D structure databases

    ProteinModelPortaliQ985M5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    HOGENOMiHOG000139600.
    KOiK00108.
    OMAiLTDDYNG.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q985M5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEADFVIIG SGSAGSAMAY RLSEDGKHSV IVIEFGGSDI GPLIQMPSAL    50
    SIPLNMSLYD WGFASEPEPH LGGRVLATPR GKVIGGSSSI NGMVYVRGHA 100
    RDFDHWAEEG ATGWGFADVL PYFKRMEDND GGEDGWRGHG GPLHVQRGSR 150
    KNPLYGAFVE AGRQAGFELT DDYNGSKQEG FGPMEQTISG GRRWSAASAY 200
    LKPALKRKNV SLVKGFARRV IIENQRAIGV EIEAHKQIQV VKARREVIVA 250
    ASSINSPKIL MLSGIGPAEH LRENGIAVVA DRPGVGRNLQ DHMELYIQQE 300
    STKPITLNSV LNPFSKALIG AQWLFFKSGL GATNHFEAAA FVRSRAGVDY 350
    PDIQYHFIPA AVRYDGKAAA KSHGFQAHVG PMRSKSRGSV TLRSPDPKAK 400
    PVIRFNYMSH PDDWTEFRHC IRLTREIFGQ SAFDAFRGQE ISPGSHVQSD 450
    DDLDVFIRDH AESAYHPCGT CKMGRADDVT SVVDPECRVI GVDGLRVADS 500
    SIFPRVTNGN LNAPSIMTGE KASDHILGRT PLAPSNQEPW INPRWQVSDR 550
    Length:550
    Mass (Da):60,125
    Last modified:October 1, 2001 - v1
    Checksum:iB3FC4F94EA6B5E21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB54037.1.
    RefSeqiNP_107892.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB54037; BAB54037; BAB54037.
    GeneIDi1230547.
    KEGGimlo:mll7609.
    PATRICi22486421. VBIMesLot2464_6088.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB54037.1 .
    RefSeqi NP_107892.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q985M5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mll7609.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB54037 ; BAB54037 ; BAB54037 .
    GeneIDi 1230547.
    KEGGi mlo:mll7609.
    PATRICi 22486421. VBIMesLot2464_6088.

    Phylogenomic databases

    eggNOGi COG2303.
    HOGENOMi HOG000139600.
    KOi K00108.
    OMAi LTDDYNG.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .
    BioCyci MLOT266835:GJ9L-6045-MONOMER.

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiBETA_RHILO
    AccessioniPrimary (citable) accession number: Q985M5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3