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Q985M5 (BETA_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:mll7609
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_0000205593

Regions

Nucleotide binding5 – 3430FAD By similarity

Sites

Active site4661 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q985M5 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: B3FC4F94EA6B5E21

FASTA55060,125
        10         20         30         40         50         60 
MLEADFVIIG SGSAGSAMAY RLSEDGKHSV IVIEFGGSDI GPLIQMPSAL SIPLNMSLYD 

        70         80         90        100        110        120 
WGFASEPEPH LGGRVLATPR GKVIGGSSSI NGMVYVRGHA RDFDHWAEEG ATGWGFADVL 

       130        140        150        160        170        180 
PYFKRMEDND GGEDGWRGHG GPLHVQRGSR KNPLYGAFVE AGRQAGFELT DDYNGSKQEG 

       190        200        210        220        230        240 
FGPMEQTISG GRRWSAASAY LKPALKRKNV SLVKGFARRV IIENQRAIGV EIEAHKQIQV 

       250        260        270        280        290        300 
VKARREVIVA ASSINSPKIL MLSGIGPAEH LRENGIAVVA DRPGVGRNLQ DHMELYIQQE 

       310        320        330        340        350        360 
STKPITLNSV LNPFSKALIG AQWLFFKSGL GATNHFEAAA FVRSRAGVDY PDIQYHFIPA 

       370        380        390        400        410        420 
AVRYDGKAAA KSHGFQAHVG PMRSKSRGSV TLRSPDPKAK PVIRFNYMSH PDDWTEFRHC 

       430        440        450        460        470        480 
IRLTREIFGQ SAFDAFRGQE ISPGSHVQSD DDLDVFIRDH AESAYHPCGT CKMGRADDVT 

       490        500        510        520        530        540 
SVVDPECRVI GVDGLRVADS SIFPRVTNGN LNAPSIMTGE KASDHILGRT PLAPSNQEPW 

       550 
INPRWQVSDR 

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000012 Genomic DNA. Translation: BAB54037.1.
RefSeqNP_107892.1. NC_002678.2.

3D structure databases

ProteinModelPortalQ985M5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266835.mll7609.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB54037; BAB54037; BAB54037.
GeneID1230547.
KEGGmlo:mll7609.
PATRIC22486421. VBIMesLot2464_6088.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMALTDDYNG.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-6045-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_RHILO
AccessionPrimary (citable) accession number: Q985M5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways