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Protein

Guanylate kinase

Gene

gmk

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:mlr7857
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705911 – 218Guanylate kinaseAdd BLAST218

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr7857

Structurei

3D structure databases

ProteinModelPortaliQ984S9
SMRiQ984S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 193Guanylate kinase-likeAdd BLAST180

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037638
KOiK00942
OrthoDBiPOG091H01Q4

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q984S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRDLGSRI RRRGLMLVLS SPSGAGKSTI ARNLLESDSS LELSVSVTTR
60 70 80 90 100
PRRGSEIEGV HYHFRTMREF ERLRDSDALL EWAEVHGNCY ATPREPAELA
110 120 130 140 150
LAQGRDMLFD IDWQGAQQLK EKMRADIVSI FILPPSMKEL KARLKRRAED
160 170 180 190 200
QEAVIETRLK NARNEIEHWK EYDFVIVNDD LDRAFAEVRG IVVAERLRRD
210
RRPGLFDFVS GLLDEKTV
Length:218
Mass (Da):25,105
Last modified:August 2, 2002 - v2
Checksum:i310AA2D4300532DB
GO

Sequence cautioni

The sequence BAB54234 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB54234.1 Different initiation.
RefSeqiWP_027053294.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB54234; BAB54234; BAB54234
GeneIDi31701364
KEGGimlo:mlr7857

Similar proteinsi

Entry informationi

Entry nameiKGUA_RHILO
AccessioniPrimary (citable) accession number: Q984S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: May 23, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health