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Q984K6

- PUR5_RHILO

UniProt

Q984K6 - PUR5_RHILO

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMLOT266835:GJ9L-6315-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:mll7962
    OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
    Taxonomic identifieri266835 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
    ProteomesiUP000000552: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148238Add
    BLAST

    Proteomic databases

    PRIDEiQ984K6.

    Interactioni

    Protein-protein interaction databases

    STRINGi266835.mll7962.

    Structurei

    3D structure databases

    ProteinModelPortaliQ984K6.
    SMRiQ984K6. Positions 22-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiGEATCEV.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q984K6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKRDTSQPK TGQPKTSKRR NGLTYAEAGV DIDAGNLMVE KIKPLVRATR    50
    RPGADGEIGG FGGLFDLKAA GFTDPVLVAA NDGVGTKLKI AIDAGKHDTI 100
    GIDLVAMCVN DIVVQGAEPL FFLDYFATGK LDPDQGAAIV GGIAEGCRQA 150
    GCALIGGETA EMPGMYHGND YDLAGFAVGA AERGQLLPTD DIVEGDVLLG 200
    LASSGLHSNG FSLVRRIVAA SGLAWSDPAP FNDEATLAEA LLEPTRIYVK 250
    SILKAIRNTH GIKALAHITG GGFPENIPRV LPKDFSAELD LEAIDVPPVF 300
    SWLAKTGGVA PEEMMRTFNC GVGMILAVAS GQAAQVAAVL QEAGETVTPI 350
    GRIVPRRDAG VIYRGSIGL 369
    Length:369
    Mass (Da):38,418
    Last modified:October 1, 2001 - v1
    Checksum:i2DC3BA404506C81D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB53624.1.
    RefSeqiNP_108163.1. NC_002678.2.

    Genome annotation databases

    EnsemblBacteriaiBAB53624; BAB53624; BAB53624.
    GeneIDi1230815.
    KEGGimlo:mll7962.
    PATRICi22486985. VBIMesLot2464_6369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000012 Genomic DNA. Translation: BAB53624.1 .
    RefSeqi NP_108163.1. NC_002678.2.

    3D structure databases

    ProteinModelPortali Q984K6.
    SMRi Q984K6. Positions 22-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266835.mll7962.

    Proteomic databases

    PRIDEi Q984K6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB53624 ; BAB53624 ; BAB53624 .
    GeneIDi 1230815.
    KEGGi mlo:mll7962.
    PATRICi 22486985. VBIMesLot2464_6369.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi GEATCEV.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci MLOT266835:GJ9L-6315-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MAFF303099.

    Entry informationi

    Entry nameiPUR5_RHILO
    AccessioniPrimary (citable) accession number: Q984K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3