Reviewed,
UniProtKB/Swiss-Prot Q983U5 (FUMC_RHILO)
Last modified
November 3, 2009.
Version 43.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Fumarate hydratase class II Short name=Fumarase C EC=4.2.1.2 | ||||
| Gene names |
| ||||
| Organism | Rhizobium loti (Mesorhizobium loti) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 381 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Phyllobacteriaceae › Mesorhizobium |
Protein attributes
| Sequence length | 465 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-malate = fumarate + H2O. HAMAP MF_00743 |
| Pathway | Carbohydrate metabolism; tricarboxylic acid cycle. HAMAP MF_00743 |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Miscellaneous | There are 2 substrate binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors By similarity. |
| Sequence similarities | Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Cellular component | Cytoplasm |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fumarate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycleInferred from electronic annotation. Source: HAMAP |
| Cellular component | tricarboxylic acid cycle enzyme complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | fumarate hydratase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 465 | 465 | Fumarate hydratase class II HAMAP MF_00743 | PRO_0000161304 | |||||
Regions | |||||||||
| Region | 131 – 134 | 4 | B site By similarity | ||||||
| Region | 141 – 143 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 102 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti." Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. Tabata S.DNA Res. 7:331-338(2000) [PubMed: 11214968] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MAFF303099. |
Cross-references
Sequence databases | |
|---|---|
| BA000012 Genomic DNA. Translation: BAB53785.1. | |
| RefSeq | NP_108324.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1YFM based on UniProtKB P08417. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1230976. |
| GenomeReviews | Gene locus mll8172 in contig BA000012_GR. |
| KEGG | mlo:mll8172. |
| NMPDR | fig|266835.1.peg.6423. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q983U5. |
| OMA | GSQGHFE. |
Enzyme and pathway databases | |
| BRENDA | 4.2.1.2. 3315. |
Family and domain databases | |
| HAMAP | MF_00743. [Tree] |
| InterPro | IPR003031. D_crystallin. IPR005677. Fum_hydII. IPR018951. Fumarase_C_C. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view] |
| Pfam | PF10415. FumaraseC_C. 1 hit. PF00206. Lyase_1. 1 hit. [Graphical view] |
| PRINTS | PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE. |
| TIGRFAMs | TIGR00979. fumC_II. 1 hit. |
| PROSITE | PS00163. FUMARATE_LYASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FUMC_RHILO | ||||||||
| Accession | Primary (citable) accession number: Q983U5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


