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Q983J4

- HGD_RHILO

UniProt

Q983J4 - HGD_RHILO

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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei308 – 3081Proton acceptorUniRule annotation
Metal bindingi351 – 3511IronUniRule annotation
Metal bindingi357 – 3571IronUniRule annotation
Binding sitei366 – 3661homogentisateUniRule annotation
Metal bindingi387 – 3871IronUniRule annotation
Binding sitei387 – 3871homogentisateUniRule annotation

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMLOT266835:GJ9L-6580-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Ordered Locus Names:mlr8303
OrganismiRhizobium loti (strain MAFF303099) (Mesorhizobium loti)
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000000552: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Homogentisate 1,2-dioxygenasePRO_0000220253Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mlr8303.

Structurei

3D structure databases

ProteinModelPortaliQ983J4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiFQSPVAC.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q983J4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNTGRLGFV KLGAGIKEDR MAFSYMPGFG NDFETETLPG SLPQGRNSPQ
60 70 80 90 100
RPAYGLYAEQ LSGSPFTAPR GTNERSWLYR IRPSVKHTGR FKAASYPLWK
110 120 130 140 150
TAPNVGDHEL ALGQYRWNPV PMPKEPTDFI QGMRSITTAG DVLGQTGMAA
160 170 180 190 200
HVYVANRSMV DDHFFNADGE LLVVPQVGAL RFVTEMGVIE LRPGEIAVLP
210 220 230 240 250
RGLVFKAELV DKDVRGYVCE NYGAKLTLPD RGPIGANCLA NPRDFKTPCA
260 270 280 290 300
WFEEKETPCR LIVKWCGNFH VTEIGHSPLD VVAWHGNYAP YKYDLATFSP
310 320 330 340 350
VGAILFDHPD PSIFTVLTAP SGEEGTANID FVIFPPRWLV AEDTFRPPWY
360 370 380 390 400
HRNIMSEFMG LIHGQYDAKE EGFVPGGISL HNLMLAHGPD APGFEKASRA
410 420 430 440 450
DLKPVKLDNT MAFMFETRFP QMLTRYGAEL ETRQDNYIDC WADLKKRFNG

TPEGDWS
Length:457
Mass (Da):51,046
Last modified:October 1, 2001 - v1
Checksum:i6A20B69E9A2B2BD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB53887.1.
RefSeqiNP_108426.1. NC_002678.2.

Genome annotation databases

EnsemblBacteriaiBAB53887; BAB53887; BAB53887.
GeneIDi1231078.
KEGGimlo:mlr8303.
PATRICi22487519. VBIMesLot2464_6633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000012 Genomic DNA. Translation: BAB53887.1 .
RefSeqi NP_108426.1. NC_002678.2.

3D structure databases

ProteinModelPortali Q983J4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266835.mlr8303.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB53887 ; BAB53887 ; BAB53887 .
GeneIDi 1231078.
KEGGi mlo:mlr8303.
PATRICi 22487519. VBIMesLot2464_6633.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi FQSPVAC.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci MLOT266835:GJ9L-6580-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MAFF303099.

Entry informationi

Entry nameiHGD_RHILO
AccessioniPrimary (citable) accession number: Q983J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2001
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3