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Q983J4 (HGD_RHILO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:mlr8303
OrganismRhizobium loti (strain MAFF303099) (Mesorhizobium loti) [Complete proteome] [HAMAP]
Taxonomic identifier266835 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
   Biological processPhenylalanine catabolism
Tyrosine catabolism
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-phenylalanine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tyrosine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionhomogentisate 1,2-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_0000220253

Sites

Metal binding3511Iron By similarity
Metal binding3571Iron By similarity
Metal binding3871Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q983J4 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 6A20B69E9A2B2BD1

FASTA45751,046
        10         20         30         40         50         60 
MVNTGRLGFV KLGAGIKEDR MAFSYMPGFG NDFETETLPG SLPQGRNSPQ RPAYGLYAEQ 

        70         80         90        100        110        120 
LSGSPFTAPR GTNERSWLYR IRPSVKHTGR FKAASYPLWK TAPNVGDHEL ALGQYRWNPV 

       130        140        150        160        170        180 
PMPKEPTDFI QGMRSITTAG DVLGQTGMAA HVYVANRSMV DDHFFNADGE LLVVPQVGAL 

       190        200        210        220        230        240 
RFVTEMGVIE LRPGEIAVLP RGLVFKAELV DKDVRGYVCE NYGAKLTLPD RGPIGANCLA 

       250        260        270        280        290        300 
NPRDFKTPCA WFEEKETPCR LIVKWCGNFH VTEIGHSPLD VVAWHGNYAP YKYDLATFSP 

       310        320        330        340        350        360 
VGAILFDHPD PSIFTVLTAP SGEEGTANID FVIFPPRWLV AEDTFRPPWY HRNIMSEFMG 

       370        380        390        400        410        420 
LIHGQYDAKE EGFVPGGISL HNLMLAHGPD APGFEKASRA DLKPVKLDNT MAFMFETRFP 

       430        440        450 
QMLTRYGAEL ETRQDNYIDC WADLKKRFNG TPEGDWS 

« Hide

References

[1]"Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti."
Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S., Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y., Nakayama S. expand/collapse author list , Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M., Tabata S.
DNA Res. 7:331-338(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MAFF303099.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000012 Genomic DNA. Translation: BAB53887.1.
RefSeqNP_108426.1. NC_002678.2.

3D structure databases

ProteinModelPortalQ983J4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266835.mlr8303.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB53887; BAB53887; BAB53887.
GeneID1231078.
KEGGmlo:mlr8303.
PATRIC22487519. VBIMesLot2464_6633.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycMLOT266835:GJ9L-6580-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_RHILO
AccessionPrimary (citable) accession number: Q983J4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways