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Protein

Viral CASP8 and FADD-like apoptosis regulator

Gene

MC159L

Organism
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits TNFRSF1A, TNFRSF6 and TNFRSF12 induced apoptosis. May interfere with caspase-8 recruitment and activation at the death-inducing signaling complex (DISC). May lead to higher virus production and contribute to virus persistence and oncogenicity.2 Publications

GO - Biological processi

  • positive regulation of necroptotic process Source: UniProtKB
  • suppression by virus of host apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Host-virus interaction, Inhibition of host apoptosis by viral FLIP-like protein, Modulation of host cell apoptosis by virus

Enzyme and pathway databases

ReactomeiR-HSA-140534. Ligand-dependent caspase activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Viral CASP8 and FADD-like apoptosis regulator
Short name:
v-CFLAR
Alternative name(s):
Viral FLICE-inhibitory protein
Short name:
v-FLIP
Gene namesi
Ordered Locus Names:MC159L
ORF Names:H-H2.2
OrganismiMolluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Taxonomic identifieri10280 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeMolluscipoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000869 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Viral CASP8 and FADD-like apoptosis regulatorPRO_0000072819Add
BLAST

Interactioni

Subunit structurei

Associates with the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. Interacts with FADD.

Structurei

Secondary structure

1
241
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63Combined sources
Helixi10 – 178Combined sources
Helixi22 – 3110Combined sources
Turni32 – 354Combined sources
Helixi42 – 5110Combined sources
Helixi57 – 6610Combined sources
Helixi70 – 778Combined sources
Helixi81 – 855Combined sources
Turni86 – 894Combined sources
Beta strandi90 – 923Combined sources
Helixi95 – 10410Combined sources
Helixi109 – 12214Combined sources
Helixi124 – 1296Combined sources
Helixi136 – 14510Combined sources
Helixi155 – 1639Combined sources
Helixi167 – 18721Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BBRX-ray1.20A1-187[»]
2BBZX-ray3.80A/B/C/D1-241[»]
2F1SX-ray1.40A1-183[»]
ProteinModelPortaliQ98325.
SMRiQ98325. Positions 2-191.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98325.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7871DED 1PROSITE-ProRule annotationAdd
BLAST
Domaini95 – 17581DED 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 DED (death effector) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK04724.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
[Graphical view]
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50168. DED. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSKEVPSL PFLRHLLEEL DSHEDSLLLF LCHDAAPGCT TVTQALCSLS
60 70 80 90 100
QQRKLTLAAL VEMLYVLQRM DLLKSRFGLS KEGAEQLLGT SFLTRYRKLM
110 120 130 140 150
VCVGEELDSS ELRALRLFAC NLNPSLSTAL SESSRFVELV LALENVGLVS
160 170 180 190 200
PSSVSVLADM LRTLRRLDLC QQLVEYEQQE QARYRYCYAA SPSLPVRTLR
210 220 230 240
RGHGASEHEQ LCMPVQESSD SPELLRTPVQ ESSSDSPEQT T
Length:241
Mass (Da):26,940
Last modified:February 1, 1997 - v1
Checksum:i155C9FB0B969E216
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60315 Genomic DNA. Translation: AAC55287.1.
U86888 Genomic DNA. Translation: AAB57923.1.
PIRiT30761.
RefSeqiNP_044110.1. NC_001731.1.

Genome annotation databases

GeneIDi1487017.
KEGGivg:1487017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60315 Genomic DNA. Translation: AAC55287.1.
U86888 Genomic DNA. Translation: AAB57923.1.
PIRiT30761.
RefSeqiNP_044110.1. NC_001731.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BBRX-ray1.20A1-187[»]
2BBZX-ray3.80A/B/C/D1-241[»]
2F1SX-ray1.40A1-183[»]
ProteinModelPortaliQ98325.
SMRiQ98325. Positions 2-191.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1487017.
KEGGivg:1487017.

Phylogenomic databases

KOiK04724.

Enzyme and pathway databases

ReactomeiR-HSA-140534. Ligand-dependent caspase activation.

Miscellaneous databases

EvolutionaryTraceiQ98325.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR001875. DED_dom.
[Graphical view]
PfamiPF01335. DED. 1 hit.
[Graphical view]
SMARTiSM00031. DED. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50168. DED. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes."
    Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.
    Science 273:813-816(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "A random DNA sequencing, computer-based approach for the generation of a gene map of Molluscum contagiosum virus."
    Moratilla M., Agromayor M., Nunez A., Funes J.M., Varas A.J., Lopez-Estebaranz J.L., Esteban M., Martin-Gallardo A.
    Virus Genes 14:73-80(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 91-241.
  3. Cited for: FUNCTION.
  4. "Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis."
    Bertin J., Armstrong R.C., Ottilie S., Martin D.A., Wang Y., Banks S., Wang G.-H., Senkevich T.G., Alnemri E.S., Moss B., Lenardo M.J., Tomaselli K.J., Cohen J.I.
    Proc. Natl. Acad. Sci. U.S.A. 94:1172-1176(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Requirement of cooperative functions of two repeated death effector domains in caspase-8 and in MC159 for induction and inhibition of apoptosis, respectively."
    Tsukumo S., Yonehara S.
    Genes Cells 4:541-549(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiCFLA_MCV1
AccessioniPrimary (citable) accession number: Q98325
Secondary accession number(s): O11298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.