Q98267 (NTP1_MCV1) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 67.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Nucleoside triphosphatase I EC=3.6.1.15 Alternative name(s): NPH-I Nucleoside triphosphate phosphohydrolase I Short name=NPH I | ||||
| Gene names |
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| Organism | Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) [Reference proteome] | ||||
| Taxonomic identifier | 10280 [NCBI] | ||||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Molluscipoxvirus › ![]() | ||||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 634 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | DNA-dependent ATPase required for providing the needed energy to achieve the termination of early transcripts. Acts in concert with the RAP94 subunit of the virion RNA polymerase and the capping enzyme/VTF to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex. NPH-I must bind ssDNA in order to exhibit ATPase activity By similarity. |
| Catalytic activity | NTP + H2O = NDP + phosphate. |
| Subunit structure | Monomer. Interacts (via C-terminus) with RAP94 (via N-terminus). Interacts with the cap-specific mRNA (nucleoside-2'-O-)-methyltransferase By similarity. |
| Subcellular location | Virion By similarity. Note: Virion core enzyme By similarity. |
| Sequence similarities | Belongs to the helicase family. NPH I subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription |
| Cellular component | Virion |
| Ligand | ATP-binding DNA-binding Nucleotide-binding |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | virion Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA bindingInferred from electronic annotation. Source: UniProtKB-KW helicase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 634 | 634 | Nucleoside triphosphatase I | PRO_0000099104 | |||||
Regions | |||||||||
| Domain | 41 – 203 | 163 | Helicase ATP-binding | ||||||
| Domain | 355 – 531 | 177 | Helicase C-terminal | ||||||
| Nucleotide binding | 54 – 61 | 8 | ATP By similarity | ||||||
| Region | 456 – 523 | 68 | Binding to the cap-specific mRNA (nucleoside-2'-O-)-methyltransferase By similarity | ||||||
| Motif | 140 – 143 | 4 | DEXH box | ||||||
Sequences
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References
| [1] | "Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes." Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B. Science 273:813-816(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U60315 Genomic DNA. Translation: AAC55228.1. |
| PIR | T30702. |
| RefSeq | NP_044051.1. NC_001731.1. |
3D structure databases | |
| ProteinModelPortal | Q98267. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1487119. |
Phylogenomic databases | |
| ProtClustDB | CLSP2509799. |
Family and domain databases | |
| InterPro | IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR013676. NPHI_C. IPR000330. SNF2_N. [Graphical view] |
| Pfam | PF00271. Helicase_C. 1 hit. PF08469. NPHI_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view] |
| SMART | SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view] |
| PROSITE | PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NTP1_MCV1 | ||||||||
| Accession | Primary (citable) accession number: Q98267 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Viral Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
