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Protein

Glutathione peroxidase

Gene

GPX1

Organism
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May protect the virus and component of infected cells from oxidative damage by peroxides whose formation may be stimulated by infection.1 Publication

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641By similarity
Sitei64 – 641Subject to oxidation and hydroselenide loss to dehydroalanineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase (EC:1.11.1.9)
Short name:
GPx
Short name:
GSHPx
Gene namesi
Name:GPX1
Ordered Locus Names:MC066L
OrganismiMolluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Taxonomic identifieri10280 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeMolluscipoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000869 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Glutathione peroxidasePRO_0000318766Add
BLAST

Post-translational modificationi

During periods of oxidative stress, Sec-64 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ98234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

KOiK00432.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q98234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGSGARFP RFSELCAKYA AQLAAAETRS VYAFSARPIT GGEPVSLGFL
60 70 80 90 100
RGRVLLIENV ASLUGSTVRE YTQMNELQRR LGARGLVVLG FPCNQFGHQE
110 120 130 140 150
NAQNAEILPS LKHVRPGNGF EPNFMLFEKC EVNGARAHPL FAFLREALPA
160 170 180 190 200
PSDDMSTLVS DPQLIAWSPV CRNDVAWNFE KFLVGADGTP VRRYSHRCQT
210 220
LAVEPDIEAL LPPPARGYYA
Length:220
Mass (Da):24,218
Last modified:February 26, 2008 - v2
Checksum:iC51FC8C2BF704247
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei64 – 641SelenocysteineBy similarity

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60315 Genomic DNA. Translation: AAC55194.2.
PIRiT30668.
RefSeqiNP_044017.2. NC_001731.1.

Genome annotation databases

GeneIDi1487085.
KEGGivg:1487085.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60315 Genomic DNA. Translation: AAC55194.2.
PIRiT30668.
RefSeqiNP_044017.2. NC_001731.1.

3D structure databases

ProteinModelPortaliQ98234.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1487085.
KEGGivg:1487085.

Phylogenomic databases

KOiK00432.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX_MCV1
AccessioniPrimary (citable) accession number: Q98234
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This enzyme has been acquitted by lateral transfer from its human host and has retained 74% identity with cellular GPX1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.