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Reviewed, UniProtKB/Swiss-Prot Q98234 (GPX_MCV1)

Last modified February 9, 2010. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Glutathione peroxidase
      Short name=GSHPx
      Short name=GPx
    EC=1.11.1.9
Gene names
Name: GPX1
Ordered Locus Names: MC066L
OrganismMolluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Taxonomic identifier10280 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeMolluscipoxvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

May protect the virus and component of infected cells from oxidative damage by peroxides whose formation may be stimulated by infection. Ref.1

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Miscellaneous

This enzyme has been acquited by lateral transfer from its human host and has retained 74% identity with cellular GPX1.

Sequence similarities

Belongs to the glutathione peroxidase family.

Ontologies

Keywords
   Coding sequence diversitySelenocysteine
   LigandSelenium
   Molecular functionOxidoreductase
Peroxidase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

response to oxidative stress

Inferred from electronic annotation. Source: InterPro

   Molecular functionglutathione peroxidase activity

Inferred from electronic annotation. Source: EC

selenium binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Glutathione peroxidase
PRO_0000318766

Sites

Active site641 By similarity

Amino acid modifications

Non-standard residue641Selenocysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98234-1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: C51FC8C2BF704247

FASTA22024,218
        10         20         30         40         50         60 
MADGSGARFP RFSELCAKYA AQLAAAETRS VYAFSARPIT GGEPVSLGFL RGRVLLIENV 

        70         80         90        100        110        120 
ASLUGSTVRE YTQMNELQRR LGARGLVVLG FPCNQFGHQE NAQNAEILPS LKHVRPGNGF 

       130        140        150        160        170        180 
EPNFMLFEKC EVNGARAHPL FAFLREALPA PSDDMSTLVS DPQLIAWSPV CRNDVAWNFE 

       190        200        210        220 
KFLVGADGTP VRRYSHRCQT LAVEPDIEAL LPPPARGYYA 

« Hide

References

[1]"Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes."
Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.
Science 273:813-816(1996) [PubMed: 8670425] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U60315 Genomic DNA. Translation: AAC55194.2.
PIRT30668.
RefSeqNP_044017.2.

3D structure databases

HSSPHSSP built from PDB template 2F8A based on UniProtKB P07203.
ModBaseSearch...

Genome annotation databases

GeneID1487085.

Enzyme and pathway databases

BRENDA1.11.1.9. 295531.

Family and domain databases

InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPX_MCV1
AccessionPrimary (citable) accession number: Q98234
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 9, 2010
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents