Reviewed, UniProtKB/Swiss-Prot Q98234 (GPX_MCV1)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase
      Short name=GSHPx
      Short name=GPx
    EC=1.11.1.9

Gene names

Name:	GPX1
Ordered Locus Names:	MC066L

Organism

Molluscum contagiosum virus subtype 1 (MOCV) (MCVI)

Taxonomic identifier

10280 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Molluscipoxvirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May protect the virus and component of infected cells from oxidative damage by peroxides whose formation may be stimulated by infection. Ref.1
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Miscellaneous	This enzyme has been acquited by lateral transfer from its human host and has retained 74% identity with cellular GPX1.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Coding sequence diversity	Selenocysteine
Ligand	Selenium
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC selenium binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Glutathione peroxidase		PRO_0000318766
Sites
	Active site	64	1	By similarity
Amino acid modifications
	Non-standard residue	64	1	Selenocysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98234-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: C51FC8C2BF704247	FASTA	220	24,218
	10 20 30 40 50 60 MADGSGARFP RFSELCAKYA AQLAAAETRS VYAFSARPIT GGEPVSLGFL RGRVLLIENV 70 80 90 100 110 120 ASLUGSTVRE YTQMNELQRR LGARGLVVLG FPCNQFGHQE NAQNAEILPS LKHVRPGNGF 130 140 150 160 170 180 EPNFMLFEKC EVNGARAHPL FAFLREALPA PSDDMSTLVS DPQLIAWSPV CRNDVAWNFE 190 200 210 220 KFLVGADGTP VRRYSHRCQT LAVEPDIEAL LPPPARGYYA

References

[1]	"Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes." Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B. Science 273:813-816(1996) [PubMed: 8670425] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U60315 Genomic DNA. Translation: AAC55194.2.
PIR	T30668.
RefSeq	NP_044017.2.
3D structure databases
HSSP	HSSP built from PDB template 2F8A based on UniProtKB P07203.
ModBase	Search...
Genome annotation databases
GeneID	1487085.
Enzyme and pathway databases
BRENDA	1.11.1.9. 295531.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX_MCV1

Accession

Primary (citable) accession number: Q98234

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	February 9, 2010
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)