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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).By similarity

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2For GATase activityBy similarity1
Metal bindingi429ZincBy similarity1
Metal bindingi437ZincBy similarity1
Metal bindingi440ZincBy similarity1
Metal bindingi443ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi248 – 258ATPBy similarityAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthase (EC:6.3.4.20)
Alternative name(s):
7-cyano-7-carbaguanine synthase
Archaeosine biosynthesis protein QueC
PreQ(0) synthase
Gene namesi
Name:queC
Ordered Locus Names:SSO0016
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002469902 – 4647-cyano-7-deazaguanine synthaseAdd BLAST463

Proteomic databases

PRIDEiQ981C9.

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0016.

Structurei

3D structure databases

ProteinModelPortaliQ981C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 227Glutamine amidotransferase type-2Add BLAST226

Sequence similaritiesi

Belongs to the QueC family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0449. LUCA.
COG0603. LUCA.
HOGENOMiHOG000270539.
KOiK06920.
OMAiNEMEFVR.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF06508. QueC. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q981C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSVSGVLIL NPKNFEKVEL KLASILKKAE DRGRDSFGIV VIQKDGTVKV
60 70 80 90 100
RKSIGKPSEK EELLYGILDE DSRVVIANNR AEPTTEYVRQ KTEDDIQPFI
110 120 130 140 150
GDRYIVTHNG IIANDLELEK KYELKRKTKI DSAILPLLLD KTWDGNLEAL
160 170 180 190 200
KGILEQIKGS FALVIGDKKN PDRIFLAQNF KPLYMAYDHS LESLFFTSLD
210 220 230 240 250
EYFDAKPFDP VNITKLEPYS VVMVTSNKLI TTLPIMEKRK KYRVLVVASG
260 270 280 290 300
GLDSTVAATK LLREGHEVTL IHFNYHHKAE EKEREAVRKI AEYLQIPLLE
310 320 330 340 350
INTDLFKIIG HATLIKGGGE IVKDRKGEEG AEFAHEWVPA RNLIFFSVSL
360 370 380 390 400
AIAEAYGYDA IASGINLEEA GAYPDNEMEF IRMLNKLSPY ATGPNKRIEI
410 420 430 440 450
LMPVGNLVKH EIVKLGYEIG APLHLTWSCY EGGQKHCGKC GPCYMRKMAF
460
RINGLKDPVE YDEE
Length:464
Mass (Da):52,383
Last modified:October 1, 2001 - v1
Checksum:i1B1EA2A9FA494ED4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40383.1.
PIRiH90140.
RefSeqiWP_009989631.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40383; AAK40383; SSO0016.
GeneIDi27426311.
KEGGisso:SSO0016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40383.1.
PIRiH90140.
RefSeqiWP_009989631.1. NC_002754.1.

3D structure databases

ProteinModelPortaliQ981C9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0016.

Proteomic databases

PRIDEiQ981C9.

Protocols and materials databases

DNASUi1455274.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40383; AAK40383; SSO0016.
GeneIDi27426311.
KEGGisso:SSO0016.

Phylogenomic databases

eggNOGiarCOG00039. Archaea.
COG0449. LUCA.
COG0603. LUCA.
HOGENOMiHOG000270539.
KOiK06920.
OMAiNEMEFVR.

Enzyme and pathway databases

UniPathwayiUPA00391.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.60.20.10. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF13537. GATase_7. 1 hit.
PF06508. QueC. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQUEC_SULSO
AccessioniPrimary (citable) accession number: Q981C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.