ID   PAP1_MCV1               Reviewed;         470 AA.
AC   Q98199;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   08-NOV-2023, entry version 82.
DE   RecName: Full=Poly(A) polymerase catalytic subunit;
DE            EC=2.7.7.19;
DE   AltName: Full=Poly(A) polymerase large subunit;
DE            Short=PAP-L;
GN   Name=PAPL; OrderedLocusNames=MC031L;
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus;
OC   Molluscum contagiosum virus.
OX   NCBI_TaxID=10280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
CC   -!- FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC   -!- SUBUNIT: Heterodimer of a large (catalytic) subunit and a small
CC       (regulatory) subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae poly(A) polymerase catalytic
CC       subunit family. {ECO:0000305}.
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DR   EMBL; U60315; AAC55159.1; -; Genomic_DNA.
DR   PIR; T30633; T30633.
DR   RefSeq; NP_043982.1; NC_001731.1.
DR   SMR; Q98199; -.
DR   GeneID; 1487052; -.
DR   KEGG; vg:1487052; -.
DR   OrthoDB; 3428at10239; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd20919; polyA_pol_Pox; 1.
DR   Gene3D; 1.20.1270.320; Poxvirus poly(A) polymerase, N domain; 1.
DR   Gene3D; 3.30.460.60; Poxvirus poly(A) polymerase, nucleotidyltransferase domain; 1.
DR   InterPro; IPR004976; PolyA_pol_cat_Poxvir.
DR   InterPro; IPR037265; PolyA_pol_cat_sf.
DR   InterPro; IPR024231; PolyA_pol_nucTrfase_Poxvir.
DR   InterPro; IPR038419; PolyA_pol_nucTrfase_sf_Poxvir.
DR   InterPro; IPR024397; Poxvirus_polyA_pol_cat_C.
DR   InterPro; IPR024398; Poxvirus_polyA_pol_cat_N.
DR   InterPro; IPR038337; Poxvirus_polyA_pol_cat_N_sf.
DR   Pfam; PF03296; Pox_polyA_pol; 1.
DR   Pfam; PF12629; Pox_polyA_pol_C; 1.
DR   Pfam; PF12630; Pox_polyA_pol_N; 1.
DR   PIRSF; PIRSF015693; VAC-48L_nuct; 1.
DR   SUPFAM; SSF160957; Poly(A) polymerase catalytic subunit-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..470
FT                   /note="Poly(A) polymerase catalytic subunit"
FT                   /id="PRO_0000308935"
FT   ACT_SITE        192
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        194
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   470 AA;  53911 MW;  0360478588EE7659 CRC64;
     MNGAQFELLR EYLGRPPTLN QYFIFKPQAR AIQRIMRFDT DVFFALIKKN KKRFFARIGG
     SASEINARVL SYFVKQRATT KVGRILSIIE LQSVLVNSYT EIMGVLTLPA PPVYNSVVRL
     HYCSMERLAE EVLWSYNVAF RSGKVMGRHC VSNLVVHVNK LMSEYLRRHN RTAICYGSYS
     LHLLNSRIEY GDIDILQTNA RLFLINLAFL IYFITGRNVL LLKVPYLKSY IVMQDEEGRH
     IIDSFNIRQG TMQNVPKVLV DNIYIIDPVV QLMNTLKMLS QIDRLEDLGE RMAKMRLRLA
     TLLEYARYHH CVSFGGGARL RLHMRLDAGA RIVLVDTRCY GLGYRECRCY LDEARLLQDI
     SKLNADAAVV DFEAVSNSVF LIHQGIMYTY FSNTVLLRSE DAIHDVSERA VCAHITLYHL
     LVGCNYQELL ADLLNSLVSR EKCPVVGVVA RDKKVGRHGV IDIEKDVITH
//