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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921By similarity
Active sitei194 – 1941By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

mRNA processing, Transcription

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:MC031L
OrganismiMolluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Taxonomic identifieri10280 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeMolluscipoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000869: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Poly(A) polymerase catalytic subunitPRO_0000308935Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ98199.
SMRiQ98199. Positions 5-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98199-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGAQFELLR EYLGRPPTLN QYFIFKPQAR AIQRIMRFDT DVFFALIKKN
60 70 80 90 100
KKRFFARIGG SASEINARVL SYFVKQRATT KVGRILSIIE LQSVLVNSYT
110 120 130 140 150
EIMGVLTLPA PPVYNSVVRL HYCSMERLAE EVLWSYNVAF RSGKVMGRHC
160 170 180 190 200
VSNLVVHVNK LMSEYLRRHN RTAICYGSYS LHLLNSRIEY GDIDILQTNA
210 220 230 240 250
RLFLINLAFL IYFITGRNVL LLKVPYLKSY IVMQDEEGRH IIDSFNIRQG
260 270 280 290 300
TMQNVPKVLV DNIYIIDPVV QLMNTLKMLS QIDRLEDLGE RMAKMRLRLA
310 320 330 340 350
TLLEYARYHH CVSFGGGARL RLHMRLDAGA RIVLVDTRCY GLGYRECRCY
360 370 380 390 400
LDEARLLQDI SKLNADAAVV DFEAVSNSVF LIHQGIMYTY FSNTVLLRSE
410 420 430 440 450
DAIHDVSERA VCAHITLYHL LVGCNYQELL ADLLNSLVSR EKCPVVGVVA
460 470
RDKKVGRHGV IDIEKDVITH
Length:470
Mass (Da):53,911
Last modified:February 1, 1997 - v1
Checksum:i0360478588EE7659
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60315 Genomic DNA. Translation: AAC55159.1.
PIRiT30633.
RefSeqiNP_043982.1. NC_001731.1.

Genome annotation databases

GeneIDi1487052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60315 Genomic DNA. Translation: AAC55159.1.
PIRiT30633.
RefSeqiNP_043982.1. NC_001731.1.

3D structure databases

ProteinModelPortaliQ98199.
SMRiQ98199. Positions 5-469.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1487052.

Family and domain databases

InterProiIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamiPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes."
    Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.
    Science 273:813-816(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPAP1_MCV1
AccessioniPrimary (citable) accession number: Q98199
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.