Q98199 (PAP1_MCV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly(A) polymerase catalytic subunit
EC=2.7.7.19

Alternative name(s):
Poly(A) polymerase large subunit
Short name=PAP-L

Gene names

Name:	PAPL
Ordered Locus Names:	MC031L

Organism

Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) [Reference proteome]

Taxonomic identifier

10280 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Molluscipoxvirus › Molluscum contagiosum virus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Polymerase that creates the 3'-poly(A) tail of mRNA's.
Catalytic activity	ATP + RNA(n) = diphosphate + RNA(n+1).
Subunit structure	Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.
Sequence similarities	Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Keywords
Biological process	Transcription mRNA processing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polynucleotide adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Poly(A) polymerase catalytic subunit		PRO_0000308935
Sites
	Active site	192	1	By similarity
	Active site	194	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q98199 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 0360478588EE7659	FASTA	470	53,911
	10 20 30 40 50 60 MNGAQFELLR EYLGRPPTLN QYFIFKPQAR AIQRIMRFDT DVFFALIKKN KKRFFARIGG 70 80 90 100 110 120 SASEINARVL SYFVKQRATT KVGRILSIIE LQSVLVNSYT EIMGVLTLPA PPVYNSVVRL 130 140 150 160 170 180 HYCSMERLAE EVLWSYNVAF RSGKVMGRHC VSNLVVHVNK LMSEYLRRHN RTAICYGSYS 190 200 210 220 230 240 LHLLNSRIEY GDIDILQTNA RLFLINLAFL IYFITGRNVL LLKVPYLKSY IVMQDEEGRH 250 260 270 280 290 300 IIDSFNIRQG TMQNVPKVLV DNIYIIDPVV QLMNTLKMLS QIDRLEDLGE RMAKMRLRLA 310 320 330 340 350 360 TLLEYARYHH CVSFGGGARL RLHMRLDAGA RIVLVDTRCY GLGYRECRCY LDEARLLQDI 370 380 390 400 410 420 SKLNADAAVV DFEAVSNSVF LIHQGIMYTY FSNTVLLRSE DAIHDVSERA VCAHITLYHL 430 440 450 460 470 LVGCNYQELL ADLLNSLVSR EKCPVVGVVA RDKKVGRHGV IDIEKDVITH

References

[1]	"Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes." Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B. Science 273:813-816(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U60315 Genomic DNA. Translation: AAC55159.1.
PIR	T30633.
RefSeq	NP_043982.1. NC_001731.1.
3D structure databases
ProteinModelPortal	Q98199.
SMR	Q98199. Positions 5-469.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1487052.
Phylogenomic databases
ProtClustDB	PHA2996.
Family and domain databases
InterPro	IPR024231. Pox_polyA_pol_nucTrfase. IPR004976. Poxvirus_polyA_pol_cat. IPR024397. Poxvirus_polyA_pol_cat_C. IPR024398. Poxvirus_polyA_pol_cat_N. [Graphical view]
Pfam	PF03296. Pox_polyA_pol. 1 hit. PF12629. Pox_polyA_pol_C. 1 hit. PF12630. Pox_polyA_pol_N. 1 hit. [Graphical view]
PIRSF	PIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PAP1_MCV1

Accession

Primary (citable) accession number: Q98199

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	February 1, 1997
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program