Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q98199 (PAP1_MCV1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly(A) polymerase catalytic subunit

EC=2.7.7.19
Alternative name(s):
Poly(A) polymerase large subunit
Short name=PAP-L
Gene names
Name:PAPL
Ordered Locus Names:MC031L
OrganismMolluscum contagiosum virus subtype 1 (MOCV) (MCVI) [Reference proteome]
Taxonomic identifier10280 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeMolluscipoxvirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activity

ATP + RNA(n) = diphosphate + RNA(n+1).

Subunit structure

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit By similarity.

Sequence similarities

Belongs to the poxviridae poly(A) polymerase catalytic subunit family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Poly(A) polymerase catalytic subunit
PRO_0000308935

Sites

Active site1921 By similarity
Active site1941 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q98199 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 0360478588EE7659

FASTA47053,911
        10         20         30         40         50         60 
MNGAQFELLR EYLGRPPTLN QYFIFKPQAR AIQRIMRFDT DVFFALIKKN KKRFFARIGG 

        70         80         90        100        110        120 
SASEINARVL SYFVKQRATT KVGRILSIIE LQSVLVNSYT EIMGVLTLPA PPVYNSVVRL 

       130        140        150        160        170        180 
HYCSMERLAE EVLWSYNVAF RSGKVMGRHC VSNLVVHVNK LMSEYLRRHN RTAICYGSYS 

       190        200        210        220        230        240 
LHLLNSRIEY GDIDILQTNA RLFLINLAFL IYFITGRNVL LLKVPYLKSY IVMQDEEGRH 

       250        260        270        280        290        300 
IIDSFNIRQG TMQNVPKVLV DNIYIIDPVV QLMNTLKMLS QIDRLEDLGE RMAKMRLRLA 

       310        320        330        340        350        360 
TLLEYARYHH CVSFGGGARL RLHMRLDAGA RIVLVDTRCY GLGYRECRCY LDEARLLQDI 

       370        380        390        400        410        420 
SKLNADAAVV DFEAVSNSVF LIHQGIMYTY FSNTVLLRSE DAIHDVSERA VCAHITLYHL 

       430        440        450        460        470 
LVGCNYQELL ADLLNSLVSR EKCPVVGVVA RDKKVGRHGV IDIEKDVITH 

« Hide

References

[1]"Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes."
Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.
Science 273:813-816(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U60315 Genomic DNA. Translation: AAC55159.1.
PIRT30633.
RefSeqNP_043982.1. NC_001731.1.

3D structure databases

ProteinModelPortalQ98199.
SMRQ98199. Positions 5-469.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1487052.

Family and domain databases

InterProIPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxvirus_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
[Graphical view]
PfamPF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
[Graphical view]
PIRSFPIRSF015693. VAC-48L_nuct. 1 hit.
ProtoNetSearch...

Entry information

Entry namePAP1_MCV1
AccessionPrimary (citable) accession number: Q98199
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families