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Q98199

- PAP1_MCV1

UniProt

Q98199 - PAP1_MCV1

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei192 – 1921By similarity
    Active sitei194 – 1941By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    Gene namesi
    Name:PAPL
    Ordered Locus Names:MC031L
    OrganismiMolluscum contagiosum virus subtype 1 (MOCV) (MCVI)
    Taxonomic identifieri10280 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeMolluscipoxvirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000000869: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Poly(A) polymerase catalytic subunitPRO_0000308935Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ98199.
    SMRiQ98199. Positions 5-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q98199-1 [UniParc]FASTAAdd to Basket

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    MNGAQFELLR EYLGRPPTLN QYFIFKPQAR AIQRIMRFDT DVFFALIKKN    50
    KKRFFARIGG SASEINARVL SYFVKQRATT KVGRILSIIE LQSVLVNSYT 100
    EIMGVLTLPA PPVYNSVVRL HYCSMERLAE EVLWSYNVAF RSGKVMGRHC 150
    VSNLVVHVNK LMSEYLRRHN RTAICYGSYS LHLLNSRIEY GDIDILQTNA 200
    RLFLINLAFL IYFITGRNVL LLKVPYLKSY IVMQDEEGRH IIDSFNIRQG 250
    TMQNVPKVLV DNIYIIDPVV QLMNTLKMLS QIDRLEDLGE RMAKMRLRLA 300
    TLLEYARYHH CVSFGGGARL RLHMRLDAGA RIVLVDTRCY GLGYRECRCY 350
    LDEARLLQDI SKLNADAAVV DFEAVSNSVF LIHQGIMYTY FSNTVLLRSE 400
    DAIHDVSERA VCAHITLYHL LVGCNYQELL ADLLNSLVSR EKCPVVGVVA 450
    RDKKVGRHGV IDIEKDVITH 470
    Length:470
    Mass (Da):53,911
    Last modified:February 1, 1997 - v1
    Checksum:i0360478588EE7659
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60315 Genomic DNA. Translation: AAC55159.1.
    PIRiT30633.
    RefSeqiNP_043982.1. NC_001731.1.

    Genome annotation databases

    GeneIDi1487052.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U60315 Genomic DNA. Translation: AAC55159.1 .
    PIRi T30633.
    RefSeqi NP_043982.1. NC_001731.1.

    3D structure databases

    ProteinModelPortali Q98199.
    SMRi Q98199. Positions 5-469.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1487052.

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes."
      Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.
      Science 273:813-816(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPAP1_MCV1
    AccessioniPrimary (citable) accession number: Q98199
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3