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Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activityi

ATP + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei192By similarity1
Active sitei194By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processmRNA processing, Transcription
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
Alternative name(s):
Poly(A) polymerase large subunit
Short name:
PAP-L
Gene namesi
Name:PAPL
Ordered Locus Names:MC031L
OrganismiMolluscum contagiosum virus subtype 1 (MOCV) (MCVI)
Taxonomic identifieri10280 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeMolluscipoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000869 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003089351 – 470Poly(A) polymerase catalytic subunitAdd BLAST470

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ98199.
SMRiQ98199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK21315.
OrthoDBiVOG0900007K.

Family and domain databases

InterProiView protein in InterPro
IPR024231. Pox_polyA_pol_nucTrfase.
IPR004976. Poxviridae_polyA_pol_cat.
IPR024397. Poxvirus_polyA_pol_cat_C.
IPR024398. Poxvirus_polyA_pol_cat_N.
PfamiView protein in Pfam
PF03296. Pox_polyA_pol. 1 hit.
PF12629. Pox_polyA_pol_C. 1 hit.
PF12630. Pox_polyA_pol_N. 1 hit.
PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGAQFELLR EYLGRPPTLN QYFIFKPQAR AIQRIMRFDT DVFFALIKKN
60 70 80 90 100
KKRFFARIGG SASEINARVL SYFVKQRATT KVGRILSIIE LQSVLVNSYT
110 120 130 140 150
EIMGVLTLPA PPVYNSVVRL HYCSMERLAE EVLWSYNVAF RSGKVMGRHC
160 170 180 190 200
VSNLVVHVNK LMSEYLRRHN RTAICYGSYS LHLLNSRIEY GDIDILQTNA
210 220 230 240 250
RLFLINLAFL IYFITGRNVL LLKVPYLKSY IVMQDEEGRH IIDSFNIRQG
260 270 280 290 300
TMQNVPKVLV DNIYIIDPVV QLMNTLKMLS QIDRLEDLGE RMAKMRLRLA
310 320 330 340 350
TLLEYARYHH CVSFGGGARL RLHMRLDAGA RIVLVDTRCY GLGYRECRCY
360 370 380 390 400
LDEARLLQDI SKLNADAAVV DFEAVSNSVF LIHQGIMYTY FSNTVLLRSE
410 420 430 440 450
DAIHDVSERA VCAHITLYHL LVGCNYQELL ADLLNSLVSR EKCPVVGVVA
460 470
RDKKVGRHGV IDIEKDVITH
Length:470
Mass (Da):53,911
Last modified:February 1, 1997 - v1
Checksum:i0360478588EE7659
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60315 Genomic DNA. Translation: AAC55159.1.
PIRiT30633.
RefSeqiNP_043982.1. NC_001731.1.

Genome annotation databases

GeneIDi1487052.
KEGGivg:1487052.

Similar proteinsi

Entry informationi

Entry nameiPAP1_MCV1
AccessioniPrimary (citable) accession number: Q98199
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families