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Q98157 (VMI2_HHV8P) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Viral macrophage inflammatory protein 2
Alternative name(s):
Viral macrophage inflammatory protein II
Short name=vMIP-II
vMIP-1B
Gene names
Name:ORF K4
OrganismHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) [Reference proteome]
Taxonomic identifier868565 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length94 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.

Subunit structure

Monomer.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

immune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 9474Viral macrophage inflammatory protein 2
PRO_0000005245

Amino acid modifications

Disulfide bond34 ↔ 58
Disulfide bond35 ↔ 74

Secondary structure

................. 94
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q98157 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 44F749BED18DD128

FASTA9410,486
        10         20         30         40         50         60 
MDTKGILLVA VLTALLCLQS GDTLGASWHR PDKCCLGYQK RPLPQVLLSS WYPTSQLCSK 

        70         80         90 
PGVIFLTKRG RQVCADKSKD WVKKLMQQLP VTAR 

« Hide

References

« Hide 'large scale' references
[1]"Kaposi's sarcoma-associated human herpesvirus-8 encodes homologs of macrophage inflammatory protein-1 and interleukin-6."
Nicholas J., Ruvolo V.R., Burns W.H., Sandford G., Wan X., Ciufo D., Hendrickson S., Guo H.G., Hayward G.S., Reitz M.S.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV."
Moore P.S., Bashoff C., Weiss R.A., Chang Y.
Science 274:1739-1744(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)."
Russo J.J., Bohenzky R.A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S.
Proc. Natl. Acad. Sci. U.S.A. 93:14862-14867(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]Sun R., Lin S.-F., Miller G.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Kaposi's sarcoma-associated herpesvirus immune modulation: an overview."
Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.
J. Gen. Virol. 87:1781-1804(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation."
Fernandez E.J., Wilken J., Thompson D.A., Peiper S.C., Lolis E.
Biochemistry 39:12837-12844(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
[7]"The solution structure of the anti-HIV chemokine vMIP-II."
Liwang A.C., Wang Z.-X., Sun Y., Peiper S.C., Liwang P.J.
Protein Sci. 8:2270-2280(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U67775 Genomic DNA. Translation: AAB61702.1.
U75698 Genomic DNA. Translation: AAC57093.1.
U93872 Genomic DNA. Translation: AAB62642.1.
U71365 Genomic DNA. Translation: AAC34941.1.
AF148805 Genomic DNA. Translation: ABD28861.1.
RefSeqYP_001129362.1. NC_009333.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1CM9X-ray2.10A/B21-94[»]
1HFFNMR-A24-33[»]
1HFGNMR-A24-94[»]
1HFNNMR-A24-94[»]
1HHVNMR-A21-94[»]
1VMPNMR-A24-94[»]
2FHTX-ray1.70A24-94[»]
2FJ2X-ray2.30A/B/C/D24-94[»]
DisProtDP00685.
ProteinModelPortalQ98157.
SMRQ98157. Positions 21-93.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4961514.

Phylogenomic databases

ProtClustDBCLSP2511821.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ98157.

Entry information

Entry nameVMI2_HHV8P
AccessionPrimary (citable) accession number: Q98157
Secondary accession number(s): D0UZM1, Q2HRC3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: March 19, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references