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Protein

Viral macrophage inflammatory protein 2

Gene

ORF K4

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Viral macrophage inflammatory protein 2
Alternative name(s):
Viral macrophage inflammatory protein II
Short name:
vMIP-II
vMIP-1B
Gene namesi
Name:ORF K4
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000942: Genome

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 9474Viral macrophage inflammatory protein 2PRO_0000005245Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 58
Disulfide bondi35 ↔ 74

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1
94
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi27 – 293Combined sources
Beta strandi32 – 343Combined sources
Helixi45 – 473Combined sources
Beta strandi48 – 536Combined sources
Beta strandi58 – 603Combined sources
Beta strandi62 – 676Combined sources
Beta strandi68 – 703Combined sources
Beta strandi72 – 765Combined sources
Helixi80 – 889Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CM9X-ray2.10A/B21-94[»]
1HFFNMR-A24-33[»]
1HFGNMR-A24-94[»]
1HFNNMR-A24-94[»]
1HHVNMR-A21-94[»]
1VMPNMR-A24-94[»]
2FHTX-ray1.70A24-94[»]
2FJ2X-ray2.30A/B/C/D24-94[»]
DisProtiDP00685.
ProteinModelPortaliQ98157.
SMRiQ98157. Positions 21-93.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98157.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q98157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTKGILLVA VLTALLCLQS GDTLGASWHR PDKCCLGYQK RPLPQVLLSS
60 70 80 90
WYPTSQLCSK PGVIFLTKRG RQVCADKSKD WVKKLMQQLP VTAR
Length:94
Mass (Da):10,486
Last modified:February 1, 1997 - v1
Checksum:i44F749BED18DD128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67775 Genomic DNA. Translation: AAB61702.1.
U75698 Genomic DNA. Translation: AAC57093.1.
U93872 Genomic DNA. Translation: AAB62642.1.
U71365 Genomic DNA. Translation: AAC34941.1.
AF148805 Genomic DNA. Translation: ABD28861.1.
RefSeqiYP_001129362.1. NC_009333.1.

Genome annotation databases

GeneIDi4961514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67775 Genomic DNA. Translation: AAB61702.1.
U75698 Genomic DNA. Translation: AAC57093.1.
U93872 Genomic DNA. Translation: AAB62642.1.
U71365 Genomic DNA. Translation: AAC34941.1.
AF148805 Genomic DNA. Translation: ABD28861.1.
RefSeqiYP_001129362.1. NC_009333.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CM9X-ray2.10A/B21-94[»]
1HFFNMR-A24-33[»]
1HFGNMR-A24-94[»]
1HFNNMR-A24-94[»]
1HHVNMR-A21-94[»]
1VMPNMR-A24-94[»]
2FHTX-ray1.70A24-94[»]
2FJ2X-ray2.30A/B/C/D24-94[»]
DisProtiDP00685.
ProteinModelPortaliQ98157.
SMRiQ98157. Positions 21-93.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4961514.

Miscellaneous databases

EvolutionaryTraceiQ98157.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Kaposi's sarcoma-associated human herpesvirus-8 encodes homologs of macrophage inflammatory protein-1 and interleukin-6."
    Nicholas J., Ruvolo V.R., Burns W.H., Sandford G., Wan X., Ciufo D., Hendrickson S., Guo H.G., Hayward G.S., Reitz M.S.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV."
    Moore P.S., Bashoff C., Weiss R.A., Chang Y.
    Science 274:1739-1744(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Sun R., Lin S.-F., Miller G.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview."
    Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.
    J. Gen. Virol. 87:1781-1804(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation."
    Fernandez E.J., Wilken J., Thompson D.A., Peiper S.C., Lolis E.
    Biochemistry 39:12837-12844(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  7. "The solution structure of the anti-HIV chemokine vMIP-II."
    Liwang A.C., Wang Z.-X., Sun Y., Peiper S.C., Liwang P.J.
    Protein Sci. 8:2270-2280(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiVMI2_HHV8P
AccessioniPrimary (citable) accession number: Q98157
Secondary accession number(s): D0UZM1, Q2HRC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.