Reviewed, UniProtKB/Swiss-Prot Q98157 (VMI2_HHV8)

Names and origin

Protein names

Recommended name:
    Viral macrophage inflammatory protein 2
Alternative name(s):
    Viral macrophage inflammatory protein II
      Short name=vMIP-II
    vMIP-1B

Gene names

Name:

ORF K4

Organism

Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)

Taxonomic identifier

37296 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
Subunit structure	Monomer.
Subcellular location	Secreted.
Sequence similarities	Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	3D-structure
Gene Ontology (GO)
Biological process	immune response Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chemokine activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Chain

21 – 94

74

Viral macrophage inflammatory protein 2

PRO_0000005245

Amino acid modifications

Disulfide bond

34 ↔ 58

Disulfide bond

35 ↔ 74

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

94

Helix Strand Turn

Details...

Beta strand

32 – 34

3

Helix

45 – 47

3

Beta strand

48 – 53

6

Beta strand

58 – 60

3

Beta strand

63 – 67

5

Beta strand

72 – 75

4

Helix

80 – 88

9

Sequences

	Sequence		Length	Mass (Da)
	Q98157-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 44F749BED18DD128	FASTA	94	10,486
	10 20 30 40 50 60 MDTKGILLVA VLTALLCLQS GDTLGASWHR PDKCCLGYQK RPLPQVLLSS WYPTSQLCSK 70 80 90 PGVIFLTKRG RQVCADKSKD WVKKLMQQLP VTAR

References

[1]	"Kaposi's sarcoma-associated human herpesvirus-8 encodes homologs of macrophage inflammatory protein-1 and interleukin-6." Nicholas J., Ruvolo V.R., Burns W.H., Sandford G., Wan X., Ciufo D., Hendrickson S., Guo H.G., Hayward G.S., Reitz M.S. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV." Moore P.S., Bashoff C., Weiss R.A., Chang Y. Science 274:1739-1744(1996) [PubMed: 8939871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)." Russo J.J., Bohenzky R.A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., Moore P.S. Proc. Natl. Acad. Sci. U.S.A. 93:14862-14867(1996) [PubMed: 8962146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	Sun R., Lin S.-F., Miller G. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation." Fernandez E.J., Wilken J., Thompson D.A., Peiper S.C., Lolis E. Biochemistry 39:12837-12844(2000) [PubMed: 11041848] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
[6]	"The solution structure of the anti-HIV chemokine vMIP-II." Liwang A.C., Wang Z.-X., Sun Y., Peiper S.C., Liwang P.J. Protein Sci. 8:2270-2280(1999) [PubMed: 10595530] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U67775 Genomic DNA. Translation: AAB61702.1.
U75698 Genomic DNA. Translation: AAC57093.1.
U93872 Genomic DNA. Translation: AAB62642.1.
U71365 Genomic DNA. Translation: AAC34941.1.

RefSeq

YP_001129362.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1CM9	X-ray	2.10	A/B	21-94	[»]
1HFF	NMR	-	A	24-33	[»]
1HFG	NMR	-	A	24-94	[»]
1HFN	NMR	-	A	24-94	[»]
1HHV	NMR	-	A	21-94	[»]
1VMP	NMR	-	A	24-94	[»]
2FHT	X-ray	1.70	A	24-94	[»]
2FJ2	X-ray	2.30	A/B/C/D	24-94	[»]

ModBase

Search...

Genome annotation databases

GeneID

4961514.

Family and domain databases

InterPro

IPR000827. CC_chemkine_sml_CS.
IPR001811. Chemokine_IL8.
[Graphical view]

Pfam

PF00048. IL8. 1 hit.
[Graphical view]

SMART

SM00199. SCY. 1 hit.
[Graphical view]

PROSITE

PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

VMI2_HHV8

Accession

Primary (citable) accession number: Q98157

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	February 1, 1997
Last modified:	December 15, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)