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Q98157

- VMI2_HHV8P

UniProt

Q98157 - VMI2_HHV8P

Protein

Viral macrophage inflammatory protein 2

Gene

ORF K4

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Viral macrophage inflammatory protein 2
    Alternative name(s):
    Viral macrophage inflammatory protein II
    Short name:
    vMIP-II
    vMIP-1B
    Gene namesi
    Name:ORF K4
    OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
    Taxonomic identifieri868565 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000000942: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 9474Viral macrophage inflammatory protein 2PRO_0000005245Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 58
    Disulfide bondi35 ↔ 74

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    Secondary structure

    1
    94
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi27 – 293
    Beta strandi32 – 343
    Helixi45 – 473
    Beta strandi48 – 536
    Beta strandi58 – 603
    Beta strandi62 – 676
    Beta strandi68 – 703
    Beta strandi72 – 765
    Helixi80 – 889

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1CM9X-ray2.10A/B21-94[»]
    1HFFNMR-A24-33[»]
    1HFGNMR-A24-94[»]
    1HFNNMR-A24-94[»]
    1HHVNMR-A21-94[»]
    1VMPNMR-A24-94[»]
    2FHTX-ray1.70A24-94[»]
    2FJ2X-ray2.30A/B/C/D24-94[»]
    DisProtiDP00685.
    ProteinModelPortaliQ98157.
    SMRiQ98157. Positions 21-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ98157.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q98157-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTKGILLVA VLTALLCLQS GDTLGASWHR PDKCCLGYQK RPLPQVLLSS   50
    WYPTSQLCSK PGVIFLTKRG RQVCADKSKD WVKKLMQQLP VTAR 94
    Length:94
    Mass (Da):10,486
    Last modified:February 1, 1997 - v1
    Checksum:i44F749BED18DD128
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67775 Genomic DNA. Translation: AAB61702.1.
    U75698 Genomic DNA. Translation: AAC57093.1.
    U93872 Genomic DNA. Translation: AAB62642.1.
    U71365 Genomic DNA. Translation: AAC34941.1.
    AF148805 Genomic DNA. Translation: ABD28861.1.
    RefSeqiYP_001129362.1. NC_009333.1.

    Genome annotation databases

    GeneIDi4961514.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U67775 Genomic DNA. Translation: AAB61702.1 .
    U75698 Genomic DNA. Translation: AAC57093.1 .
    U93872 Genomic DNA. Translation: AAB62642.1 .
    U71365 Genomic DNA. Translation: AAC34941.1 .
    AF148805 Genomic DNA. Translation: ABD28861.1 .
    RefSeqi YP_001129362.1. NC_009333.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1CM9 X-ray 2.10 A/B 21-94 [» ]
    1HFF NMR - A 24-33 [» ]
    1HFG NMR - A 24-94 [» ]
    1HFN NMR - A 24-94 [» ]
    1HHV NMR - A 21-94 [» ]
    1VMP NMR - A 24-94 [» ]
    2FHT X-ray 1.70 A 24-94 [» ]
    2FJ2 X-ray 2.30 A/B/C/D 24-94 [» ]
    DisProti DP00685.
    ProteinModelPortali Q98157.
    SMRi Q98157. Positions 21-93.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4961514.

    Miscellaneous databases

    EvolutionaryTracei Q98157.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Kaposi's sarcoma-associated human herpesvirus-8 encodes homologs of macrophage inflammatory protein-1 and interleukin-6."
      Nicholas J., Ruvolo V.R., Burns W.H., Sandford G., Wan X., Ciufo D., Hendrickson S., Guo H.G., Hayward G.S., Reitz M.S.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV."
      Moore P.S., Bashoff C., Weiss R.A., Chang Y.
      Science 274:1739-1744(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Sun R., Lin S.-F., Miller G.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview."
      Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.
      J. Gen. Virol. 87:1781-1804(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation."
      Fernandez E.J., Wilken J., Thompson D.A., Peiper S.C., Lolis E.
      Biochemistry 39:12837-12844(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
    7. "The solution structure of the anti-HIV chemokine vMIP-II."
      Liwang A.C., Wang Z.-X., Sun Y., Peiper S.C., Liwang P.J.
      Protein Sci. 8:2270-2280(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiVMI2_HHV8P
    AccessioniPrimary (citable) accession number: Q98157
    Secondary accession number(s): D0UZM1, Q2HRC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3