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Protein

Viral macrophage inflammatory protein 2

Gene

ORF K4

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Viral macrophage inflammatory protein 2
Alternative name(s):
Viral macrophage inflammatory protein II
Short name:
vMIP-II
vMIP-1B
Gene namesi
Name:ORF K4
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000000524521 – 94Viral macrophage inflammatory protein 2Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 58
Disulfide bondi35 ↔ 74

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni25 – 29Combined sources5
Beta strandi32 – 34Combined sources3
Helixi45 – 47Combined sources3
Beta strandi48 – 53Combined sources6
Beta strandi58 – 60Combined sources3
Beta strandi62 – 67Combined sources6
Beta strandi68 – 70Combined sources3
Beta strandi72 – 76Combined sources5
Helixi80 – 88Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CM9X-ray2.10A/B21-94[»]
1HFFNMR-A24-33[»]
1HFGNMR-A24-94[»]
1HFNNMR-A24-94[»]
1HHVNMR-A21-94[»]
1VMPNMR-A24-94[»]
2FHTX-ray1.70A24-94[»]
2FJ2X-ray2.30A/B/C/D24-94[»]
4RWSX-ray3.10C24-94[»]
DisProtiDP00685.
ProteinModelPortaliQ98157.
SMRiQ98157.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ98157.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

KOiK05408.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q98157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTKGILLVA VLTALLCLQS GDTLGASWHR PDKCCLGYQK RPLPQVLLSS
60 70 80 90
WYPTSQLCSK PGVIFLTKRG RQVCADKSKD WVKKLMQQLP VTAR
Length:94
Mass (Da):10,486
Last modified:February 1, 1997 - v1
Checksum:i44F749BED18DD128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67775 Genomic DNA. Translation: AAB61702.1.
U75698 Genomic DNA. Translation: AAC57093.1.
U93872 Genomic DNA. Translation: AAB62642.1.
U71365 Genomic DNA. Translation: AAC34941.1.
AF148805 Genomic DNA. Translation: ABD28861.1.
RefSeqiYP_001129362.1. NC_009333.1.

Genome annotation databases

GeneIDi4961514.
KEGGivg:4961514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67775 Genomic DNA. Translation: AAB61702.1.
U75698 Genomic DNA. Translation: AAC57093.1.
U93872 Genomic DNA. Translation: AAB62642.1.
U71365 Genomic DNA. Translation: AAC34941.1.
AF148805 Genomic DNA. Translation: ABD28861.1.
RefSeqiYP_001129362.1. NC_009333.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CM9X-ray2.10A/B21-94[»]
1HFFNMR-A24-33[»]
1HFGNMR-A24-94[»]
1HFNNMR-A24-94[»]
1HHVNMR-A21-94[»]
1VMPNMR-A24-94[»]
2FHTX-ray1.70A24-94[»]
2FJ2X-ray2.30A/B/C/D24-94[»]
4RWSX-ray3.10C24-94[»]
DisProtiDP00685.
ProteinModelPortaliQ98157.
SMRiQ98157.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4961514.
KEGGivg:4961514.

Phylogenomic databases

KOiK05408.

Miscellaneous databases

EvolutionaryTraceiQ98157.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVMI2_HHV8P
AccessioniPrimary (citable) accession number: Q98157
Secondary accession number(s): D0UZM1, Q2HRC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.