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Protein

Major capsid protein

Gene

MCP

Organism
Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
OrganismiHuman herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)Imported
Taxonomic identifieri37296 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotation, Host nucleusUniRule annotation, Virion

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ98139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Family and domain databases

HAMAPiMF_04016. HSV_MCP.
InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

Q98139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATLEQRPF PYLATEANLL TQIKESAADG LFKSFQLLLG KDAREGSVRF
60 70 80 90 100
EALLGVYTNV VEFVKFLETA LAAACVNTEF KDLRRMIDGK IQFKISMPTI
110 120 130 140 150
AHGDGRRPNK QRQYIVMKAC NKHHIGAEIE LAAADIELLF AEKETPLDFT
160 170 180 190 200
EYAGAIKTIT SALQFGMDAL ERGLVDTVLA VKLRHAPPVF ILKTLGDPVY
210 220 230 240 250
SERGLKKAVK SDMVSMFKAH LIEHSFFLDK AELMTRGKQY VLTMLSDMLA
260 270 280 290 300
AVCEDTVFKG VSTYTTASGQ QVAGVLETTD SVMRRLMNLL GQVESAMSGP
310 320 330 340 350
AAYASYVVRG ANLVTAVSYG RAMRNFEQFM ARIVDHPNAL PSVEGDKAAL
360 370 380 390 400
ADGHDEIQRT RIAASLVKIG DKFVAIESLQ RMYNETQFPC PLNRRIQYTY
410 420 430 440 450
FFPVGLHLPV PRYSTSVSVR GVESPAIQST ETWVVNKNNV PLCFGYQNAL
460 470 480 490 500
KSICHPRMHN PTQSAQALNQ AFPDPDGGHG YGLRYEQTPN MNLFRTFHQY
510 520 530 540 550
YMGKNVAFVP DVAQKALVTT EDLLHPTSHR LLRLEVHPFF DFFVHPCPGA
560 570 580 590 600
RGSYRATHRT MVGNIPQPLA PREFQESRGA QFDAVTNMTH VIDQLTIDVI
610 620 630 640 650
QETAFDPAYP LFCYVIEAMI HGQEEKFVMN MPLIALVIQT YWVNSGKLAF
660 670 680 690 700
VNSYHMVRFI CTHIGNGSIP KEAHGHYRKI LGELIALEQA LLKLAGHETV
710 720 730 740 750
GRTPITHLVS ALLDPHLLPP FAYHDVFTDL MQKSSRQPII KIGDQNYDNP
760 770 780 790 800
QNRATFINLR GRMEDLVNNL VNIYQTRVNE DHDERHVLDV APLDENDYNP
810 820 830 840 850
VLEKLFYYVL MPVCSNGHMC GMGVDYQNVA LTLTYNGPVF ADVVNAQDDI
860 870 880 890 900
LLHLENGTLK DILQAGDIRP TVDMIRVLCT SFLTCPFVTQ AARVITKRDP
910 920 930 940 950
AQSFATHEYG KDVAQTVLVN GFGAFAVADR SREAAETMFY PVPFNKLYAD
960 970 980 990 1000
PLVAATLHPL LPNYVTRLPN QRNAVVFNVP SNLMAEYEEW HKSPVAAYAA
1010 1020 1030 1040 1050
SCQATPGAIS AMVSMHQKLS APSFICQAKH RMHPGFAMTV VRTDEVLAEH
1060 1070 1080 1090 1100
ILYCSRASTS MFVGLPSVVR REVRSDAVTF EITHEIASLH TALGYSSVIA
1110 1120 1130 1140 1150
PAHVAAITTD MGVHCQDLFM IFPGDAYQDR QLHDYIKMKA GVQTGSPGNR
1160 1170 1180 1190 1200
MDHVGYTAGV PRCENLPGLS HGQLATCEII PTPVTSDVAY FQTPSNPRGR
1210 1220 1230 1240 1250
AASVVSCDAY SNESAERLFY DHSIPDPAYE CRSTNNPWAS QRGSLGDVLY
1260 1270 1280 1290 1300
NITFRQTALP GMYSPCRQFF HKEDIMRYNR GLYTLVNEYS ARLAGAPATS
1310 1320 1330 1340 1350
TTDLQYVVVN GTDVFLDQPC HMLQEAYPTL AASHRVMLAE YMSNKQTHAP
1360 1370
VHMGQYLIEE VAPMKRLLKL GNKVVY
Length:1,376
Mass (Da):153,402
Last modified:February 1, 1997 - v1
Checksum:iF2B7DF6F757C9215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40377 Genomic DNA. Translation: AAB08392.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40377 Genomic DNA. Translation: AAB08392.1.

3D structure databases

ProteinModelPortaliQ98139.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04016. HSV_MCP.
InterProiIPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
[Graphical view]
PfamiPF03122. Herpes_MCP. 1 hit.
[Graphical view]
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma."
    Chang Y., Cesarman E., Pessin M.S., Lee F., Culpepper J., Knowles D.M., Moore P.S.
    Science 266:1865-1869(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-203.
  2. "In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences."
    Cesarman E., Moore P.S., Rao P.H., Inghirami G., Knowles D.M., Chang Y.
    Blood 86:2708-2714(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-203.
  3. "Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection."
    Moore P.S., Chang Y.
    N. Engl. J. Med. 332:1181-1185(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-203.
  4. "Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae."
    Moore P.S., Gao S.J., Dominguez G., Cesarman E., Lungu O., Knowles D.M., Garber R., Pellett P.E., McGeoch D.J., Chang Y.
    J. Virol. 70:549-558(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ98139_HHV8
AccessioniPrimary (citable) accession number: Q98139
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.