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Q980Z8

- RPON_SULSO

UniProt

Q980Z8 - RPON_SULSO

Protein

DNA-directed RNA polymerase subunit N

Gene

rpoN

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71ZincBy similarity
    Metal bindingi10 – 101ZincBy similarity
    Metal bindingi44 – 441ZincBy similarity
    Metal bindingi45 – 451ZincBy similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-66-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit N (EC:2.7.7.6)
    Gene namesi
    Name:rpoN
    Ordered Locus Names:SSO5140
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6666DNA-directed RNA polymerase subunit NPRO_0000121362Add
    BLAST

    Interactioni

    Subunit structurei

    The S.acidocaldarius RNAP is composed of 13 subunits.

    Protein-protein interaction databases

    DIPiDIP-60643N.
    STRINGi273057.SSO5140.

    Structurei

    Secondary structure

    1
    66
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni8 – 103
    Helixi15 – 184
    Helixi21 – 266
    Helixi31 – 366
    Beta strandi37 – 393
    Helixi44 – 507
    Helixi56 – 594

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PMZX-ray3.40N/Y1-66[»]
    3HKZX-ray3.40N/W1-66[»]
    ProteinModelPortaliQ980Z8.
    SMRiQ980Z8. Positions 1-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ980Z8.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1644.
    HOGENOMiHOG000109502.
    KOiK03058.
    OMAiEIMHYRV.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    HAMAPiMF_00250. RNApol_arch_N.
    InterProiIPR009057. Homeodomain-like.
    IPR023580. RNA_pol_su_RPB10.
    IPR020789. RNA_pol_suN_Zn-BS.
    IPR000268. RNAP_N/Rpb10.
    [Graphical view]
    PfamiPF01194. RNA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
    ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF46924. SSF46924. 1 hit.
    PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q980Z8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLIPIRCFTC GSLIADKWQS FITRVNAGEN PGKVLDDLGV KRYCCRRMLL   50
    SHVDIINEVI HYTRPI 66
    Length:66
    Mass (Da):7,591
    Last modified:August 29, 2001 - v1
    Checksum:iC6774B541A1CFA13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40429.1.
    PIRiF90146.
    RefSeqiNP_341639.1. NC_002754.1.
    WP_009988875.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK40429; AAK40429; SSO5140.
    GeneIDi1455320.
    KEGGisso:SSO5140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40429.1 .
    PIRi F90146.
    RefSeqi NP_341639.1. NC_002754.1.
    WP_009988875.1. NC_002754.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PMZ X-ray 3.40 N/Y 1-66 [» ]
    3HKZ X-ray 3.40 N/W 1-66 [» ]
    ProteinModelPortali Q980Z8.
    SMRi Q980Z8. Positions 1-64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60643N.
    STRINGi 273057.SSO5140.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK40429 ; AAK40429 ; SSO5140 .
    GeneIDi 1455320.
    KEGGi sso:SSO5140.

    Phylogenomic databases

    eggNOGi COG1644.
    HOGENOMi HOG000109502.
    KOi K03058.
    OMAi EIMHYRV.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-66-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q980Z8.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    HAMAPi MF_00250. RNApol_arch_N.
    InterProi IPR009057. Homeodomain-like.
    IPR023580. RNA_pol_su_RPB10.
    IPR020789. RNA_pol_suN_Zn-BS.
    IPR000268. RNAP_N/Rpb10.
    [Graphical view ]
    Pfami PF01194. RNA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005653. RNA_pol_N/8_sub. 1 hit.
    ProDomi PD006539. RNA_pol_N/8_sub. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF46924. SSF46924. 1 hit.
    PROSITEi PS01112. RNA_POL_N_8KD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    2. "The X-ray crystal structure of RNA polymerase from Archaea."
      Hirata A., Klein B.J., Murakami K.S.
      Nature 451:851-854(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE RNA POLYMERASE COMPLEX.

    Entry informationi

    Entry nameiRPON_SULSO
    AccessioniPrimary (citable) accession number: Q980Z8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3