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Protein

DNA-directed RNA polymerase subunit N

Gene

rpoN

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71ZincBy similarity
Metal bindingi10 – 101ZincBy similarity
Metal bindingi44 – 441ZincBy similarity
Metal bindingi45 – 451ZincBy similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-66-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit N (EC:2.7.7.6)
Gene namesi
Name:rpoN
Ordered Locus Names:SSO5140
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666DNA-directed RNA polymerase subunit NPRO_0000121362Add
BLAST

Interactioni

Subunit structurei

The S.acidocaldarius RNAP is composed of 13 subunits.

Protein-protein interaction databases

DIPiDIP-60643N.
STRINGi273057.SSO5140.

Structurei

Secondary structure

1
66
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni8 – 103Combined sources
Helixi15 – 184Combined sources
Helixi21 – 266Combined sources
Helixi31 – 366Combined sources
Beta strandi37 – 393Combined sources
Helixi44 – 507Combined sources
Helixi56 – 594Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PMZX-ray3.40N/Y1-66[»]
3HKZX-ray3.40N/W1-66[»]
ProteinModelPortaliQ980Z8.
SMRiQ980Z8. Positions 1-64.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980Z8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1644.
HOGENOMiHOG000109502.
InParanoidiQ980Z8.
KOiK03058.
OMAiQLKRYCC.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00250. RNApol_arch_N.
InterProiIPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view]
PfamiPF01194. RNA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46924. SSF46924. 1 hit.
PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q980Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPIRCFTC GSLIADKWQS FITRVNAGEN PGKVLDDLGV KRYCCRRMLL
60
SHVDIINEVI HYTRPI
Length:66
Mass (Da):7,591
Last modified:August 29, 2001 - v1
Checksum:iC6774B541A1CFA13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40429.1.
PIRiF90146.
RefSeqiNP_341639.1. NC_002754.1.
WP_009988875.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40429; AAK40429; SSO5140.
GeneIDi1455320.
KEGGisso:SSO5140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40429.1.
PIRiF90146.
RefSeqiNP_341639.1. NC_002754.1.
WP_009988875.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PMZX-ray3.40N/Y1-66[»]
3HKZX-ray3.40N/W1-66[»]
ProteinModelPortaliQ980Z8.
SMRiQ980Z8. Positions 1-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60643N.
STRINGi273057.SSO5140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40429; AAK40429; SSO5140.
GeneIDi1455320.
KEGGisso:SSO5140.

Phylogenomic databases

eggNOGiCOG1644.
HOGENOMiHOG000109502.
InParanoidiQ980Z8.
KOiK03058.
OMAiQLKRYCC.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-66-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ980Z8.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
HAMAPiMF_00250. RNApol_arch_N.
InterProiIPR009057. Homeodomain-like.
IPR023580. RNA_pol_su_RPB10.
IPR020789. RNA_pol_suN_Zn-BS.
IPR000268. RNAP_N/Rpb10.
[Graphical view]
PfamiPF01194. RNA_pol_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005653. RNA_pol_N/8_sub. 1 hit.
ProDomiPD006539. RNA_pol_N/8_sub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46924. SSF46924. 1 hit.
PROSITEiPS01112. RNA_POL_N_8KD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. "The X-ray crystal structure of RNA polymerase from Archaea."
    Hirata A., Klein B.J., Murakami K.S.
    Nature 451:851-854(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE RNA POLYMERASE COMPLEX.

Entry informationi

Entry nameiRPON_SULSO
AccessioniPrimary (citable) accession number: Q980Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: March 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.