Reviewed, UniProtKB/Swiss-Prot Q980X0 (ARGB_SULSO)

Names and origin

Protein names

Recommended name:
    Acetylglutamate/acetylaminoadipate kinase
    EC=2.7.2.8
    EC=2.7.2.-
Alternative name(s):
    NAG kinase
      Short name=AGK
    N-acetyl-L-glutamate/N-acetyl-L-aminoadipate 5-phosphotransferase

Gene names

Name:	argB
Synonyms:	lysZ
Ordered Locus Names:	SSO0156

Organism

Sulfolobus solfataricus [Complete proteome] [HAMAP]

Taxonomic identifier

2287 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in both the arginine and lysine biosynthetic pathways. HAMAP MF_00082
Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082 ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082 Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5. HAMAP MF_00082
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP lysine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Acetylglutamate/acetylaminoadipate kinase HAMAP MF_00082		PRO_0000112704
Regions
	Region	35 – 36	2	Substrate binding By similarity
Sites
	Binding site	62	1	Substrate By similarity
	Binding site	167	1	Substrate By similarity
	Site	5	1	Transition state stabilizer By similarity
	Site	224	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q980X0-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: D15458B8FEA0AC48	FASTA	264	28,552
	10 20 30 40 50 60 MIVVKIGGRV VKNSLDKIIL DILNINDKVI LVHGGGDIVT DYTKRLGIEP VFVTSPEGIR 70 80 90 100 110 120 SRYTTKEELE VYIMAMSLIN KSITSKLCSL GKNAIGITGV DGGLLLAERK KRIVVIDERG 130 140 150 160 170 180 KKRIIEGGYT GKVKEVRSEI INHLVKLFDI IVVSPIALDV EERTPLNIDG DQAAFAISKA 190 200 210 220 230 240 LRANVLILLS DVEGVLVEGK VINRLTPSEA KELSKKIGPG MNRKLLMAAE SVENGVNKVI 250 260 IGSGVKDRPI INALELNGTV IANG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]	"The Sulfolobus solfataricus Lrp-like protein LysM regulates lysine biosynthesis in response to lysine availability." Brinkman A.B., Bell S.D., Lebbink R.J., de Vos W.M., van der Oost J. J. Biol. Chem. 277:29537-29549(2002) [PubMed: 12042311] [Abstract] Cited for: INVOLVEMENT IN LYSINE BIOSYNTHESIS. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006641 Genomic DNA. Translation: AAK40502.1. BK000545 Genomic DNA. Translation: DAA00050.1.
PIR	G90155.
RefSeq	NP_341712.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1453329.
GenomeReviews	Gene locus SSO0156 in contig AE006641_GR.
KEGG	sso:SSO0156.
NMPDR	fig|273057.1.peg.135.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q980X0.
OMA	LGHPPRF.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0156-MON.
BRENDA	2.7.2.8. 2070.
Family and domain databases
HAMAP	MF_00082. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR011148. GlcNAc_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_SULSO

Accession

Primary (citable) accession number: Q980X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2001
Last modified:	November 3, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)