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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401UniRule annotation
Metal bindingi40 – 401MagnesiumUniRule annotation
Binding sitei45 – 451SubstrateUniRule annotation
Active sitei88 – 881Proton acceptorUniRule annotation
Binding sitei92 – 921SubstrateUniRule annotation
Binding sitei211 – 2111SubstrateUniRule annotation
Metal bindingi230 – 2301MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:SSO0163
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)PRO_0000123742Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273057.SSO0163.

Structurei

3D structure databases

ProteinModelPortaliQ980W4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 444Substrate bindingUniRule annotation
Regioni85 – 873Substrate bindingUniRule annotation
Regioni217 – 2193Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
InParanoidiQ980W4.
KOiK15888.
OMAiWAKLKNK.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q980W4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDLTRGLL FKPIYKLYEL VLWNQIRNGP LPDHVGIIPD GNRRWARDNN
60 70 80 90 100
LSLNDAYFYG YKKLKEVLIW LLELGIKNIT VFVLSTENCD KRKQNELSII
110 120 130 140 150
TTYIKRGIQD LLEDPIVDKY EVKVSAIGKL DKLPKDLIDY LNRVVEKTSN
160 170 180 190 200
YDKRKLTLAI CYGGRQEILD AVVRLLDDYR NGKIVKSEIN EETFRKYFYD
210 220 230 240 250
SELQDIDLVI RTSGEVRISN FLLWHVAYSE LFFCEAYWPE FRKIDLWRAI
260
RSFQKRKRNF GA
Length:262
Mass (Da):31,017
Last modified:October 1, 2001 - v1
Checksum:i723828C346D1CC09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40508.1.
BK000545 Genomic DNA. Translation: DAA00056.1.
PIRiE90156.
RefSeqiWP_009990387.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40508; AAK40508; SSO0163.
GeneIDi25403626.
KEGGisso:SSO0163.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40508.1.
BK000545 Genomic DNA. Translation: DAA00056.1.
PIRiE90156.
RefSeqiWP_009990387.1. NC_002754.1.

3D structure databases

ProteinModelPortaliQ980W4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40508; AAK40508; SSO0163.
GeneIDi25403626.
KEGGisso:SSO0163.

Phylogenomic databases

eggNOGiarCOG01532. Archaea.
COG0020. LUCA.
HOGENOMiHOG000006056.
InParanoidiQ980W4.
KOiK15888.
OMAiWAKLKNK.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-149-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. "The Sulfolobus solfataricus Lrp-like protein LysM regulates lysine biosynthesis in response to lysine availability."
    Brinkman A.B., Bell S.D., Lebbink R.J., de Vos W.M., van der Oost J.
    J. Biol. Chem. 277:29537-29549(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiUPPS_SULSO
AccessioniPrimary (citable) accession number: Q980W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2001
Last modified: November 11, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.