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Protein

Peptidyl-tRNA hydrolase

Gene

pth

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.UniRule annotation1 Publication

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-164-MONOMER.
BRENDAi3.1.1.29. 6163.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolaseUniRule annotation (EC:3.1.1.29UniRule annotation)
Short name:
PTHUniRule annotation
Gene namesi
Name:pthUniRule annotation
Ordered Locus Names:SSO0175
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120Peptidyl-tRNA hydrolasePRO_0000120304Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi273057.SSO0175.

Structurei

Secondary structure

1
120
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1211Combined sources
Helixi16 – 3520Combined sources
Helixi40 – 5112Combined sources
Beta strandi56 – 638Combined sources
Helixi64 – 7613Combined sources
Beta strandi81 – 855Combined sources
Beta strandi88 – 925Combined sources
Beta strandi97 – 10610Combined sources
Helixi107 – 1148Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XTYX-ray1.80A/B/C/D1-120[»]
ProteinModelPortaliQ980V1.
SMRiQ980V1. Positions 1-120.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980V1.

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH2 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04228. Archaea.
COG1990. LUCA.
HOGENOMiHOG000227349.
InParanoidiQ980V1.
KOiK04794.
OMAiQVAHGAV.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
HAMAPiMF_00628. Pept_tRNA_hydro_arch. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q980V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKMVIVVRS DIKMGKGKIA AQVAHAAVTL VVSIINSNNL RWKEWLNEWL
60 70 80 90 100
HQGQPKIIVK VNSLDEIISR AKKAETMNLP FSIIEDAGKT QLEPGTITCL
110 120
GIGPAPENLV DSITGDLKLL
Length:120
Mass (Da):13,140
Last modified:October 1, 2001 - v1
Checksum:iA90F6A3ADC714B91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40521.1.
PIRiB90158.
RefSeqiWP_009990400.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40521; AAK40521; SSO0175.
GeneIDi27426466.
KEGGisso:SSO0175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40521.1.
PIRiB90158.
RefSeqiWP_009990400.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XTYX-ray1.80A/B/C/D1-120[»]
ProteinModelPortaliQ980V1.
SMRiQ980V1. Positions 1-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40521; AAK40521; SSO0175.
GeneIDi27426466.
KEGGisso:SSO0175.

Phylogenomic databases

eggNOGiarCOG04228. Archaea.
COG1990. LUCA.
HOGENOMiHOG000227349.
InParanoidiQ980V1.
KOiK04794.
OMAiQVAHGAV.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-164-MONOMER.
BRENDAi3.1.1.29. 6163.

Miscellaneous databases

EvolutionaryTraceiQ980V1.

Family and domain databases

Gene3Di3.40.1490.10. 1 hit.
HAMAPiMF_00628. Pept_tRNA_hydro_arch. 1 hit.
InterProiIPR023476. Pep_tRNA_hydro_II_dom.
IPR002833. PTH2.
[Graphical view]
PfamiPF01981. PTH2. 1 hit.
[Graphical view]
SUPFAMiSSF102462. SSF102462. 1 hit.
TIGRFAMsiTIGR00283. arch_pth2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTH_SULSO
AccessioniPrimary (citable) accession number: Q980V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2001
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.