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Q980U5 (GSA_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate-1-semialdehyde 2,1-aminomutase

Short name=GSA
EC=5.4.3.8
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT
Gene names
Name:hemL
Ordered Locus Names:SSO0182
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. Ref.2

Cofactor

Pyridoxal phosphate. Ref.2

Enzyme regulation

Inhibited by gabaculine. Ref.2

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375

Subunit structure

Homodimer. Ref.2

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00375.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Sequence caution

The sequence AAK40528.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutamate-1-semialdehyde 2,1-aminomutase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

transaminase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 418418Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375
PRO_0000120490

Amino acid modifications

Modified residue2601N6-(pyridoxal phosphate)lysine By similarity

Experimental info

Sequence conflict251A → F AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q980U5 [UniParc].

Last modified September 19, 2006. Version 2.
Checksum: C290C1884A38E710

FASTA41846,477
        10         20         30         40         50         60 
MNSEELWAQA KQLFAGGVNS PVRAAVKPFP FYVERGKGAY IYTVDGKKFI DYVLGYGPLI 

        70         80         90        100        110        120 
LGHSPESVKR RIVEQLERGW LFGTPSELEI ELARKIRSHI PSAQKIRFVN SGTEATMAAI 

       130        140        150        160        170        180 
RLARGYTKRS KILKFSGNYH GAHDYALVEA GSAATEYNVA TSDGVPMEIM KTVEICEFND 

       190        200        210        220        230        240 
LDCVDKKLRN EDIATVILEP VMGNAGVILP EKDFLFGLRE LTKTYNSLLI FDEVITGFRI 

       250        260        270        280        290        300 
SIGGAQSYYQ IYPDITTLGK IIGGGFPIGA VAGKAEIIDN FTPAGKVFNA GTFNANPISM 

       310        320        330        340        350        360 
IAGIATIEEL EKEYPYIIAN QAAKTLVEEL ERLLKTKHTI NHVGSMFQIF FGIDEVRNYS 

       370        380        390        400        410 
DAKRADKEYY IKFHERLLKE GVFIPPSQYE TIFTSAAHKD DVIADTIDKL MKVIGELN 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome of the crenarchaeon Sulfolobus solfataricus P2."
She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. expand/collapse author list , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.
Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
[2]"Glutamate-1-semialdehyde aminotransferase from Sulfolobus solfataricus."
Palmieri G., Di Palo M., Scaloni A., Orru S., Marino G., Sannia G.
Biochem. J. 320:541-545(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-25, CATALYTIC ACTIVITY, COFACTOR, ENZYME REGULATION, SUBUNIT.
Strain: DSM 5833 / MT-4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK40528.1. Different initiation.
PIRA90159.
RefSeqNP_341738.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ980U5.
SMRQ980U5. Positions 2-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0182.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40528; AAK40528; SSO0182.
GeneID1455338.
KEGGsso:SSO0182.

Phylogenomic databases

eggNOGCOG0001.
HOGENOMHOG000020210.
KOK01845.
OMAHYPSIDM.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-171-MONOMER.
UniPathwayUPA00251; UER00317.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_00375. HemL_aminotrans_3.
InterProIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00713. hemL. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSA_SULSO
AccessionPrimary (citable) accession number: Q980U5
Secondary accession number(s): Q9UWG3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: September 19, 2006
Last modified: May 14, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways