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Q980S9

- METK_SULSO

UniProt

Q980S9 - METK_SULSO

Protein

S-adenosylmethionine synthase

Gene

mat

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

    Catalytic activityi

    ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi139 – 1446ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. methionine adenosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. one-carbon metabolic process Source: UniProtKB-HAMAP
    2. S-adenosylmethionine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-187-MONOMER.
    UniPathwayiUPA00315; UER00080.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
    Short name:
    AdoMet synthaseUniRule annotation
    Alternative name(s):
    Methionine adenosyltransferaseUniRule annotation
    Gene namesi
    Name:matUniRule annotation
    Ordered Locus Names:SSO0199
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404S-adenosylmethionine synthasePRO_0000150041Add
    BLAST

    Proteomic databases

    PRIDEiQ980S9.

    Interactioni

    Protein-protein interaction databases

    STRINGi273057.SSO0199.

    Structurei

    Secondary structure

    1
    404
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 85
    Helixi10 – 123
    Helixi14 – 163
    Beta strandi17 – 259
    Helixi30 – 5324
    Beta strandi59 – 679
    Beta strandi70 – 745
    Beta strandi77 – 826
    Beta strandi84 – 929
    Beta strandi95 – 973
    Beta strandi99 – 1046
    Helixi107 – 12216
    Turni128 – 1303
    Beta strandi131 – 1399
    Helixi143 – 1519
    Beta strandi153 – 1553
    Beta strandi159 – 1613
    Beta strandi163 – 1697
    Helixi172 – 18514
    Helixi187 – 1926
    Beta strandi196 – 20712
    Beta strandi210 – 22011
    Helixi221 – 2233
    Helixi227 – 24822
    Beta strandi253 – 2586
    Helixi264 – 2663
    Beta strandi271 – 2755
    Helixi277 – 2804
    Beta strandi294 – 2963
    Turni312 – 3143
    Helixi316 – 33419
    Beta strandi338 – 3469
    Beta strandi357 – 36812
    Helixi372 – 38615
    Helixi389 – 3979

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HPVX-ray2.21A/B1-404[»]
    4K0BX-ray2.39A/B1-404[»]
    4L2ZX-ray2.49A/B1-404[»]
    4L7IX-ray2.19A/B1-404[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AdoMet synthase 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1812.
    HOGENOMiHOG000229842.
    KOiK00789.
    OMAiHNTDQVE.

    Family and domain databases

    HAMAPiMF_00136. S_AdoMet_synth2.
    InterProiIPR027790. AdoMet_synthase_2_family.
    IPR002795. S-AdoMet_synthetase_arc.
    [Graphical view]
    PfamiPF01941. AdoMet_Synthase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q980S9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRNINVQLNP LSDIEKLQVE LVERKGLGHP DYIADAVAEE ASRKLSLYYL    50
    KKYGVILHHN LDKTLVVGGQ ATPRFKGGDI IQPIYIIVAG RATTEVKTES 100
    GIDQIPVGTI IIESVKEWIR NNFRYLDAER HVIVDYKIGK GSSDLVGIFE 150
    ASKRVPLSND TSFGVGFAPL TKLEKLVYET ERHLNSKQFK AKLPEVGEDI 200
    KVMGLRRGNE VDLTIAMATI SELIEDVNHY INVKEQVRNQ ILDLASKIAP 250
    GYNVRVYVNT GDKIDKNILY LTVTGTSAEH GDDGMTGRGN RGVGLITPMR 300
    PMSLEATAGK NPVNHVGKLY NVLANLIANK IAQEVKDVKF SQVQVLGQIG 350
    RPIDDPLIAN VDVITYDGKL TDETKNEISG IVDEMLSSFN KLTELILEGK 400
    ATLF 404
    Length:404
    Mass (Da):44,663
    Last modified:March 27, 2002 - v2
    Checksum:iF6BD144BC36861C4
    GO

    Sequence cautioni

    The sequence AAK40544.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40544.1. Different initiation.
    PIRiA90161.
    RefSeqiNP_341754.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK40544; AAK40544; SSO0199.
    GeneIDi1455354.
    KEGGisso:SSO0199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40544.1 . Different initiation.
    PIRi A90161.
    RefSeqi NP_341754.1. NC_002754.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HPV X-ray 2.21 A/B 1-404 [» ]
    4K0B X-ray 2.39 A/B 1-404 [» ]
    4L2Z X-ray 2.49 A/B 1-404 [» ]
    4L7I X-ray 2.19 A/B 1-404 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO0199.

    Proteomic databases

    PRIDEi Q980S9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK40544 ; AAK40544 ; SSO0199 .
    GeneIDi 1455354.
    KEGGi sso:SSO0199.

    Phylogenomic databases

    eggNOGi COG1812.
    HOGENOMi HOG000229842.
    KOi K00789.
    OMAi HNTDQVE.

    Enzyme and pathway databases

    UniPathwayi UPA00315 ; UER00080 .
    BioCyci SSOL273057:GCH2-187-MONOMER.

    Family and domain databases

    HAMAPi MF_00136. S_AdoMet_synth2.
    InterProi IPR027790. AdoMet_synthase_2_family.
    IPR002795. S-AdoMet_synthetase_arc.
    [Graphical view ]
    Pfami PF01941. AdoMet_Synthase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiMETK_SULSO
    AccessioniPrimary (citable) accession number: Q980S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3