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Q980S9 (METK_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-adenosylmethionine synthase

Short name=AdoMet synthase
EC=2.5.1.6
Alternative name(s):
Methionine adenosyltransferase
Gene names
Name:mat
Ordered Locus Names:SSO0199
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the formation of S-adenosylmethionine from methionine and ATP By similarity. HAMAP-Rule MF_00136

Catalytic activity

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. HAMAP-Rule MF_00136

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00136

Pathway

Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. HAMAP-Rule MF_00136

Sequence similarities

Belongs to the AdoMet synthase 2 family.

Sequence caution

The sequence AAK40544.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404S-adenosylmethionine synthase HAMAP-Rule MF_00136
PRO_0000150041

Regions

Nucleotide binding139 – 1446ATP Potential

Secondary structure

.................................................................... 404
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q980S9 [UniParc].

Last modified March 27, 2002. Version 2.
Checksum: F6BD144BC36861C4

FASTA40444,663
        10         20         30         40         50         60 
MRNINVQLNP LSDIEKLQVE LVERKGLGHP DYIADAVAEE ASRKLSLYYL KKYGVILHHN 

        70         80         90        100        110        120 
LDKTLVVGGQ ATPRFKGGDI IQPIYIIVAG RATTEVKTES GIDQIPVGTI IIESVKEWIR 

       130        140        150        160        170        180 
NNFRYLDAER HVIVDYKIGK GSSDLVGIFE ASKRVPLSND TSFGVGFAPL TKLEKLVYET 

       190        200        210        220        230        240 
ERHLNSKQFK AKLPEVGEDI KVMGLRRGNE VDLTIAMATI SELIEDVNHY INVKEQVRNQ 

       250        260        270        280        290        300 
ILDLASKIAP GYNVRVYVNT GDKIDKNILY LTVTGTSAEH GDDGMTGRGN RGVGLITPMR 

       310        320        330        340        350        360 
PMSLEATAGK NPVNHVGKLY NVLANLIANK IAQEVKDVKF SQVQVLGQIG RPIDDPLIAN 

       370        380        390        400 
VDVITYDGKL TDETKNEISG IVDEMLSSFN KLTELILEGK ATLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK40544.1. Different initiation.
PIRA90161.
RefSeqNP_341754.1. NC_002754.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HPVX-ray2.21A/B1-404[»]
4K0BX-ray2.39A/B1-404[»]
4L2ZX-ray2.49A/B1-404[»]
4L7IX-ray2.19A/B1-404[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0199.

Proteomic databases

PRIDEQ980S9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40544; AAK40544; SSO0199.
GeneID1455354.
KEGGsso:SSO0199.

Phylogenomic databases

eggNOGCOG1812.
HOGENOMHOG000229842.
KOK00789.
OMAHNTDQVE.
ProtClustDBPRK04439.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-187-MONOMER.
UniPathwayUPA00315; UER00080.

Family and domain databases

HAMAPMF_00136. S_AdoMet_synth2.
InterProIPR027790. AdoMet_synthase_2_family.
IPR002795. S-AdoMet_synthetase_arc.
[Graphical view]
PfamPF01941. AdoMet_Synthase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMETK_SULSO
AccessionPrimary (citable) accession number: Q980S9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: February 19, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways