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Protein

S-adenosylmethionine synthase

Gene

mat

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathway:iS-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (mat)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi139 – 1446ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-187-MONOMER.
BRENDAi2.5.1.6. 6163.
UniPathwayiUPA00315; UER00080.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
Short name:
AdoMet synthaseUniRule annotation
Alternative name(s):
Methionine adenosyltransferaseUniRule annotation
Gene namesi
Name:matUniRule annotation
Ordered Locus Names:SSO0199
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404S-adenosylmethionine synthasePRO_0000150041Add
BLAST

Proteomic databases

PRIDEiQ980S9.

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0199.

Structurei

Secondary structure

1
404
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85Combined sources
Helixi10 – 123Combined sources
Helixi14 – 163Combined sources
Beta strandi17 – 259Combined sources
Helixi30 – 5324Combined sources
Beta strandi59 – 679Combined sources
Beta strandi70 – 745Combined sources
Beta strandi77 – 826Combined sources
Beta strandi84 – 929Combined sources
Beta strandi95 – 973Combined sources
Beta strandi99 – 1046Combined sources
Helixi107 – 12216Combined sources
Turni128 – 1303Combined sources
Beta strandi131 – 1399Combined sources
Helixi143 – 1519Combined sources
Beta strandi153 – 1553Combined sources
Beta strandi159 – 1613Combined sources
Beta strandi163 – 1697Combined sources
Helixi172 – 18514Combined sources
Helixi187 – 1926Combined sources
Beta strandi196 – 20712Combined sources
Beta strandi210 – 22011Combined sources
Helixi221 – 2233Combined sources
Helixi227 – 24822Combined sources
Beta strandi253 – 2586Combined sources
Helixi264 – 2663Combined sources
Beta strandi271 – 2755Combined sources
Helixi277 – 2804Combined sources
Beta strandi294 – 2963Combined sources
Turni312 – 3143Combined sources
Helixi316 – 33419Combined sources
Beta strandi338 – 3469Combined sources
Beta strandi357 – 36812Combined sources
Helixi372 – 38615Combined sources
Helixi389 – 3979Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HPVX-ray2.21A/B1-404[»]
4K0BX-ray2.39A/B1-404[»]
4L2ZX-ray2.49A/B1-404[»]
4L7IX-ray2.19A/B1-404[»]
4WS9X-ray2.80A/B/C/D/E/F/G/H/I/J/K/L1-404[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AdoMet synthase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1812.
HOGENOMiHOG000229842.
InParanoidiQ980S9.
KOiK00789.
OMAiHNTDQVE.

Family and domain databases

HAMAPiMF_00136. S_AdoMet_synth2.
InterProiIPR027790. AdoMet_synthase_2_family.
IPR002795. S-AdoMet_synthetase_arc.
[Graphical view]
PfamiPF01941. AdoMet_Synthase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q980S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNINVQLNP LSDIEKLQVE LVERKGLGHP DYIADAVAEE ASRKLSLYYL
60 70 80 90 100
KKYGVILHHN LDKTLVVGGQ ATPRFKGGDI IQPIYIIVAG RATTEVKTES
110 120 130 140 150
GIDQIPVGTI IIESVKEWIR NNFRYLDAER HVIVDYKIGK GSSDLVGIFE
160 170 180 190 200
ASKRVPLSND TSFGVGFAPL TKLEKLVYET ERHLNSKQFK AKLPEVGEDI
210 220 230 240 250
KVMGLRRGNE VDLTIAMATI SELIEDVNHY INVKEQVRNQ ILDLASKIAP
260 270 280 290 300
GYNVRVYVNT GDKIDKNILY LTVTGTSAEH GDDGMTGRGN RGVGLITPMR
310 320 330 340 350
PMSLEATAGK NPVNHVGKLY NVLANLIANK IAQEVKDVKF SQVQVLGQIG
360 370 380 390 400
RPIDDPLIAN VDVITYDGKL TDETKNEISG IVDEMLSSFN KLTELILEGK

ATLF
Length:404
Mass (Da):44,663
Last modified:March 27, 2002 - v2
Checksum:iF6BD144BC36861C4
GO

Sequence cautioni

The sequence AAK40544.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40544.1. Different initiation.
PIRiA90161.
RefSeqiNP_341754.1. NC_002754.1.
WP_010922913.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40544; AAK40544; SSO0199.
GeneIDi1455354.
KEGGisso:SSO0199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40544.1. Different initiation.
PIRiA90161.
RefSeqiNP_341754.1. NC_002754.1.
WP_010922913.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HPVX-ray2.21A/B1-404[»]
4K0BX-ray2.39A/B1-404[»]
4L2ZX-ray2.49A/B1-404[»]
4L7IX-ray2.19A/B1-404[»]
4WS9X-ray2.80A/B/C/D/E/F/G/H/I/J/K/L1-404[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0199.

Proteomic databases

PRIDEiQ980S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40544; AAK40544; SSO0199.
GeneIDi1455354.
KEGGisso:SSO0199.

Phylogenomic databases

eggNOGiCOG1812.
HOGENOMiHOG000229842.
InParanoidiQ980S9.
KOiK00789.
OMAiHNTDQVE.

Enzyme and pathway databases

UniPathwayiUPA00315; UER00080.
BioCyciSSOL273057:GCH2-187-MONOMER.
BRENDAi2.5.1.6. 6163.

Family and domain databases

HAMAPiMF_00136. S_AdoMet_synth2.
InterProiIPR027790. AdoMet_synthase_2_family.
IPR002795. S-AdoMet_synthetase_arc.
[Graphical view]
PfamiPF01941. AdoMet_Synthase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiMETK_SULSO
AccessioniPrimary (citable) accession number: Q980S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: July 22, 2015
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.