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Q980S9

- METK_SULSO

UniProt

Q980S9 - METK_SULSO

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Protein

S-adenosylmethionine synthase

Gene

mat

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP.UniRule annotation

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi139 – 1446ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. methionine adenosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. one-carbon metabolic process Source: UniProtKB-HAMAP
  2. S-adenosylmethionine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-187-MONOMER.
UniPathwayiUPA00315; UER00080.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthaseUniRule annotation (EC:2.5.1.6UniRule annotation)
Short name:
AdoMet synthaseUniRule annotation
Alternative name(s):
Methionine adenosyltransferaseUniRule annotation
Gene namesi
Name:matUniRule annotation
Ordered Locus Names:SSO0199
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404S-adenosylmethionine synthasePRO_0000150041Add
BLAST

Proteomic databases

PRIDEiQ980S9.

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0199.

Structurei

Secondary structure

1
404
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 85
Helixi10 – 123
Helixi14 – 163
Beta strandi17 – 259
Helixi30 – 5324
Beta strandi59 – 679
Beta strandi70 – 745
Beta strandi77 – 826
Beta strandi84 – 929
Beta strandi95 – 973
Beta strandi99 – 1046
Helixi107 – 12216
Turni128 – 1303
Beta strandi131 – 1399
Helixi143 – 1519
Beta strandi153 – 1553
Beta strandi159 – 1613
Beta strandi163 – 1697
Helixi172 – 18514
Helixi187 – 1926
Beta strandi196 – 20712
Beta strandi210 – 22011
Helixi221 – 2233
Helixi227 – 24822
Beta strandi253 – 2586
Helixi264 – 2663
Beta strandi271 – 2755
Helixi277 – 2804
Beta strandi294 – 2963
Turni312 – 3143
Helixi316 – 33419
Beta strandi338 – 3469
Beta strandi357 – 36812
Helixi372 – 38615
Helixi389 – 3979

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HPVX-ray2.21A/B1-404[»]
4K0BX-ray2.39A/B1-404[»]
4L2ZX-ray2.49A/B1-404[»]
4L7IX-ray2.19A/B1-404[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AdoMet synthase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1812.
HOGENOMiHOG000229842.
InParanoidiQ980S9.
KOiK00789.
OMAiHNTDQVE.

Family and domain databases

HAMAPiMF_00136. S_AdoMet_synth2.
InterProiIPR027790. AdoMet_synthase_2_family.
IPR002795. S-AdoMet_synthetase_arc.
[Graphical view]
PfamiPF01941. AdoMet_Synthase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q980S9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNINVQLNP LSDIEKLQVE LVERKGLGHP DYIADAVAEE ASRKLSLYYL
60 70 80 90 100
KKYGVILHHN LDKTLVVGGQ ATPRFKGGDI IQPIYIIVAG RATTEVKTES
110 120 130 140 150
GIDQIPVGTI IIESVKEWIR NNFRYLDAER HVIVDYKIGK GSSDLVGIFE
160 170 180 190 200
ASKRVPLSND TSFGVGFAPL TKLEKLVYET ERHLNSKQFK AKLPEVGEDI
210 220 230 240 250
KVMGLRRGNE VDLTIAMATI SELIEDVNHY INVKEQVRNQ ILDLASKIAP
260 270 280 290 300
GYNVRVYVNT GDKIDKNILY LTVTGTSAEH GDDGMTGRGN RGVGLITPMR
310 320 330 340 350
PMSLEATAGK NPVNHVGKLY NVLANLIANK IAQEVKDVKF SQVQVLGQIG
360 370 380 390 400
RPIDDPLIAN VDVITYDGKL TDETKNEISG IVDEMLSSFN KLTELILEGK

ATLF
Length:404
Mass (Da):44,663
Last modified:March 27, 2002 - v2
Checksum:iF6BD144BC36861C4
GO

Sequence cautioni

The sequence AAK40544.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006641 Genomic DNA. Translation: AAK40544.1. Different initiation.
PIRiA90161.
RefSeqiNP_341754.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40544; AAK40544; SSO0199.
GeneIDi1455354.
KEGGisso:SSO0199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006641 Genomic DNA. Translation: AAK40544.1 . Different initiation.
PIRi A90161.
RefSeqi NP_341754.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HPV X-ray 2.21 A/B 1-404 [» ]
4K0B X-ray 2.39 A/B 1-404 [» ]
4L2Z X-ray 2.49 A/B 1-404 [» ]
4L7I X-ray 2.19 A/B 1-404 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO0199.

Proteomic databases

PRIDEi Q980S9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40544 ; AAK40544 ; SSO0199 .
GeneIDi 1455354.
KEGGi sso:SSO0199.

Phylogenomic databases

eggNOGi COG1812.
HOGENOMi HOG000229842.
InParanoidi Q980S9.
KOi K00789.
OMAi HNTDQVE.

Enzyme and pathway databases

UniPathwayi UPA00315 ; UER00080 .
BioCyci SSOL273057:GCH2-187-MONOMER.

Family and domain databases

HAMAPi MF_00136. S_AdoMet_synth2.
InterProi IPR027790. AdoMet_synthase_2_family.
IPR002795. S-AdoMet_synthetase_arc.
[Graphical view ]
Pfami PF01941. AdoMet_Synthase. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiMETK_SULSO
AccessioniPrimary (citable) accession number: Q980S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: October 29, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3