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Protein

CTP synthase

Gene

pyrG

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.UniRule annotation

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP, when glutamine is the substrate. Inhibited by CTP.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes CTP from UDP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. CTP synthase (pyrG)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from UDP, the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei386 – 3861NucleophileUniRule annotation
Active sitei511 – 5111UniRule annotation
Active sitei513 – 5131UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-190-MONOMER.
BRENDAi6.3.4.2. 6163.
UniPathwayiUPA00159; UER00277.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthaseUniRule annotation (EC:6.3.4.2UniRule annotation)
Alternative name(s):
CTP synthetaseUniRule annotation
UTP--ammonia ligaseUniRule annotation
Gene namesi
Name:pyrGUniRule annotation
Ordered Locus Names:SSO0201
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535CTP synthasePRO_0000138270Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0201.

Structurei

Secondary structure

1
535
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96Combined sources
Turni14 – 174Combined sources
Helixi18 – 3114Combined sources
Beta strandi36 – 427Combined sources
Beta strandi44 – 496Combined sources
Helixi54 – 574Combined sources
Helixi72 – 809Combined sources
Helixi86 – 883Combined sources
Beta strandi89 – 913Combined sources
Helixi92 – 10413Combined sources
Turni105 – 1106Combined sources
Helixi115 – 13420Combined sources
Beta strandi137 – 1437Combined sources
Helixi150 – 1523Combined sources
Helixi153 – 16614Combined sources
Turni168 – 1703Combined sources
Beta strandi171 – 1788Combined sources
Turni183 – 1853Combined sources
Beta strandi186 – 1883Combined sources
Helixi191 – 20313Combined sources
Beta strandi208 – 2169Combined sources
Helixi220 – 22910Combined sources
Helixi234 – 2363Combined sources
Beta strandi237 – 2415Combined sources
Helixi246 – 2483Combined sources
Helixi249 – 2568Combined sources
Helixi258 – 2658Combined sources
Helixi276 – 28611Combined sources
Turni287 – 2893Combined sources
Beta strandi293 – 3019Combined sources
Helixi306 – 3094Combined sources
Helixi310 – 32213Combined sources
Beta strandi326 – 3338Combined sources
Helixi334 – 3374Combined sources
Beta strandi340 – 3423Combined sources
Turni345 – 3495Combined sources
Beta strandi352 – 3565Combined sources
Helixi365 – 37814Combined sources
Beta strandi382 – 3854Combined sources
Helixi387 – 39812Combined sources
Turni399 – 4013Combined sources
Turni409 – 4113Combined sources
Beta strandi418 – 4214Combined sources
Beta strandi425 – 4273Combined sources
Beta strandi437 – 4459Combined sources
Helixi450 – 4556Combined sources
Beta strandi457 – 46610Combined sources
Helixi472 – 4809Combined sources
Beta strandi484 – 4885Combined sources
Beta strandi494 – 4985Combined sources
Beta strandi505 – 5106Combined sources
Helixi512 – 5154Combined sources
Beta strandi518 – 5203Combined sources
Helixi523 – 53210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NVAX-ray2.50A/B1-535[»]
ProteinModelPortaliQ980S6.
SMRiQ980S6. Positions 2-533.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980S6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini302 – 535234Glutamine amidotransferase type-1UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 255255Aminator domainAdd
BLAST

Sequence similaritiesi

Belongs to the CTP synthase family.UniRule annotation
Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiarCOG00063. Archaea.
COG0504. LUCA.
HOGENOMiHOG000077514.
InParanoidiQ980S6.
KOiK01937.
OMAiFDHNITT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_01227. PyrG.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q980S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNKYIVVTG GVLSSVGKGT LVASIGMLLK RRGYNVTAVK IDPYINVDAG
60 70 80 90 100
TMNPYMHGEV FVTEDGAETD LDLGHYERFM DVNMTKYNNI TAGKVYFEVI
110 120 130 140 150
KKEREGKYLG QTVQIIPHVT DQIKDMIRYA SKINNAEITL VEIGGTVGDI
160 170 180 190 200
ESLPFLEAVR QLKLEEGEDN VIFVHIALVE YLSVTGELKT KPLQHSVQEL
210 220 230 240 250
RRIGIQPDFI VGRATLPLDD ETRRKIALFT NVKVDHIVSS YDVETSYEVP
260 270 280 290 300
IILESQKLVS KILSRLKLED RQVDLTDWIS FVNNIKGINS KKTINIALVG
310 320 330 340 350
KYTKLKDSYI SIKEAIYHAS AYIGVRPKLI WIESTDLESD TKNLNEILGN
360 370 380 390 400
VNGIIVLPGF GSRGAEGKIK AIKYAREHNI PFLGICFGFQ LSIVEFARDV
410 420 430 440 450
LGLSEANSTE INPNTKDPVI TLLDEQKNVT QLGGTMRLGA QKIILKEGTI
460 470 480 490 500
AYQLYGKKVV YERHRHRYEV NPKYVDILED AGLVVSGISE NGLVEIIELP
510 520 530
SNKFFVATQA HPEFKSRPTN PSPIYLGFIR AVASL
Length:535
Mass (Da):59,760
Last modified:October 1, 2001 - v1
Checksum:iC4E4BDE58B3DADED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40547.1.
PIRiD90161.
RefSeqiWP_009990444.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40547; AAK40547; SSO0201.
GeneIDi25403669.
KEGGisso:SSO0201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40547.1.
PIRiD90161.
RefSeqiWP_009990444.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NVAX-ray2.50A/B1-535[»]
ProteinModelPortaliQ980S6.
SMRiQ980S6. Positions 2-533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0201.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40547; AAK40547; SSO0201.
GeneIDi25403669.
KEGGisso:SSO0201.

Phylogenomic databases

eggNOGiarCOG00063. Archaea.
COG0504. LUCA.
HOGENOMiHOG000077514.
InParanoidiQ980S6.
KOiK01937.
OMAiFDHNITT.

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.
BioCyciSSOL273057:GCH2-190-MONOMER.
BRENDAi6.3.4.2. 6163.

Miscellaneous databases

EvolutionaryTraceiQ980S6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_01227. PyrG.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 1 hit.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00337. PyrG. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiPYRG_SULSO
AccessioniPrimary (citable) accession number: Q980S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 1, 2001
Last modified: November 11, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.