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Q980R2

- RPOA1_SULSO

UniProt

Q980R2 - RPOA1_SULSO

Protein

DNA-directed RNA polymerase subunit A'

Gene

rpoA1

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

    Cofactori

    Zinc.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri58 – 10144C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-213-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit A' (EC:2.7.7.6)
    Gene namesi
    Name:rpoA1
    Ordered Locus Names:SSO0225
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 880880DNA-directed RNA polymerase subunit A'PRO_0000074008Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60638N.
    STRINGi273057.SSO0225.

    Structurei

    Secondary structure

    1
    880
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 216
    Beta strandi47 – 493
    Beta strandi58 – 614
    Turni84 – 863
    Helixi87 – 937
    Beta strandi99 – 1024
    Turni108 – 1125
    Helixi114 – 1174
    Helixi124 – 13815
    Turni143 – 1453
    Helixi177 – 1848
    Helixi189 – 1968
    Turni199 – 2013
    Turni204 – 2063
    Beta strandi207 – 2115
    Helixi217 – 2193
    Helixi234 – 25320
    Beta strandi254 – 2563
    Turni259 – 2613
    Helixi262 – 27716
    Beta strandi282 – 2843
    Helixi298 – 3003
    Helixi309 – 3124
    Beta strandi314 – 3174
    Beta strandi322 – 3287
    Beta strandi330 – 3323
    Beta strandi334 – 3396
    Helixi343 – 3464
    Beta strandi347 – 3504
    Turni355 – 3573
    Helixi358 – 36710
    Turni368 – 3703
    Beta strandi371 – 3733
    Turni394 – 3963
    Helixi397 – 4004
    Beta strandi406 – 4105
    Beta strandi416 – 4205
    Helixi427 – 4293
    Beta strandi430 – 4378
    Beta strandi439 – 4457
    Helixi447 – 4493
    Helixi450 – 4534
    Turni457 – 4593
    Beta strandi461 – 4655
    Helixi470 – 47910
    Helixi483 – 4853
    Turni489 – 4924
    Beta strandi493 – 4964
    Helixi501 – 5099
    Helixi518 – 5236
    Beta strandi541 – 5433
    Helixi548 – 5525
    Turni553 – 5553
    Beta strandi562 – 5643
    Helixi571 – 5733
    Beta strandi581 – 5833
    Beta strandi585 – 5917
    Helixi600 – 6034
    Turni607 – 6093
    Helixi611 – 6177
    Helixi623 – 6308
    Helixi632 – 6398
    Turni640 – 6423
    Turni649 – 6513
    Helixi657 – 6626
    Helixi665 – 68016
    Helixi692 – 71524
    Turni716 – 7183
    Helixi724 – 7285
    Beta strandi729 – 7346
    Helixi737 – 7448
    Beta strandi760 – 7634
    Beta strandi778 – 7803
    Turni786 – 7883
    Helixi794 – 81118
    Helixi813 – 82412
    Beta strandi841 – 8433
    Beta strandi845 – 8495
    Helixi850 – 8523
    Helixi857 – 8593
    Beta strandi860 – 8645
    Helixi867 – 8748
    Turni875 – 8773

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PMZX-ray3.40A/Q1-880[»]
    3HKZX-ray3.40A/I1-880[»]
    ProteinModelPortaliQ980R2.
    SMRiQ980R2. Positions 4-879.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ980R2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA polymerase beta' chain family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri58 – 10144C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0086.
    HOGENOMiHOG000222974.
    KOiK03041.
    OMAiYFFHAMG.

    Family and domain databases

    InterProiIPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    IPR012758. RNAP_A1.
    [Graphical view]
    PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
    PF00623. RNA_pol_Rpb1_2. 1 hit.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view]
    SMARTiSM00663. RPOLA_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02390. RNA_pol_rpoA1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q980R2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKNIKGIK FGILSPDEIR KMSVTAIITP DVYDEDGTPI EGSVMDPRLG    50
    VIEPGQKCPT CGNTLGNCPG HFGHIELVRP VIHVGLVKHI YEFLKATCRR 100
    CGRVKISEDE IEKYSRIYNA IKKRWPSAAR RLTEYVKKTA MKAQVCPHCN 150
    EKQYKIKLEK PYNFYEERKE GVAKLTPSDI RERLEKIPDS DVEILGYDPT 200
    TSRPEWMILT VLPVPPITIR PSIMIESGIR AEDDLTHKLV DIVRINERLK 250
    ESIDAGAPQL IIEDLWDLLQ YHVATYFDNE IPGLPPSKHR SGRPLRTLAQ 300
    RLKGKEGRFR GNLSGKRVDF SSRTVISPDP NISIDEVGVP EIIAKTLTVP 350
    ERITPWNIEK LRQFVINGPD KWPGANYVIR PDGRRIDLRY VKDRKELAST 400
    LAPGYIIERH LIDGDIVLFN RQPSLHRISM MAHRVRVLKG LTFRLNLLVC 450
    PPYNADFDGD EMNLHVPQSE EAIAEAKEIM LVHKNIITPR YGGPIIGAAQ 500
    DYISGAYLLT VKTTLLTKEE AQQILGVADV KIDLGEPAIL APREYYTGKQ 550
    VISAFLPKDF NFHGQANVSS GPRLCKNEDC PHDSYVVIKN GILLEGVFDK 600
    KAIGNQQPES ILHWLIKEYS DEYGKWLMDN LFRVFIRFVE LQGFTMRLED 650
    VSLGDDVKKE IYNEIDRAKV EVDNLIQKYK NGELEPIPGR TLEESLENYI 700
    LDTLDKLRST AGDIASKYLD PFNFAYVMAR TGARGSVLNI TQMAAMLGQQ 750
    SVRGERIKRG YMTRTLPHFK PYDISPEARG FIYSSFRTGL KPTELFFHAA 800
    GGREGLVDTA VRTSQSGYMQ RRLINALSDL RAEYDGTVRS LYGEVVQVAY 850
    GDDGVFPMYS AHGKTVDVNR IFERVVGWKA 880
    Length:880
    Mass (Da):99,675
    Last modified:October 1, 2001 - v1
    Checksum:i5C8AE20EFC71DE25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40566.1.
    PIRiG90163.
    RefSeqiNP_341776.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK40566; AAK40566; SSO0225.
    GeneIDi1455376.
    KEGGisso:SSO0225.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK40566.1 .
    PIRi G90163.
    RefSeqi NP_341776.1. NC_002754.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PMZ X-ray 3.40 A/Q 1-880 [» ]
    3HKZ X-ray 3.40 A/I 1-880 [» ]
    ProteinModelPortali Q980R2.
    SMRi Q980R2. Positions 4-879.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60638N.
    STRINGi 273057.SSO0225.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK40566 ; AAK40566 ; SSO0225 .
    GeneIDi 1455376.
    KEGGi sso:SSO0225.

    Phylogenomic databases

    eggNOGi COG0086.
    HOGENOMi HOG000222974.
    KOi K03041.
    OMAi YFFHAMG.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-213-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q980R2.

    Family and domain databases

    InterProi IPR000722. RNA_pol_asu.
    IPR006592. RNA_pol_N.
    IPR007080. RNA_pol_Rpb1_1.
    IPR007066. RNA_pol_Rpb1_3.
    IPR007083. RNA_pol_Rpb1_4.
    IPR007081. RNA_pol_Rpb1_5.
    IPR012758. RNAP_A1.
    [Graphical view ]
    Pfami PF04997. RNA_pol_Rpb1_1. 1 hit.
    PF00623. RNA_pol_Rpb1_2. 1 hit.
    PF04983. RNA_pol_Rpb1_3. 1 hit.
    PF05000. RNA_pol_Rpb1_4. 1 hit.
    PF04998. RNA_pol_Rpb1_5. 1 hit.
    [Graphical view ]
    SMARTi SM00663. RPOLA_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02390. RNA_pol_rpoA1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
    2. "The X-ray crystal structure of RNA polymerase from Archaea."
      Hirata A., Klein B.J., Murakami K.S.
      Nature 451:851-854(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE RNA POLYMERASE COMPLEX.

    Entry informationi

    Entry nameiRPOA1_SULSO
    AccessioniPrimary (citable) accession number: Q980R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3