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Q980R2

- RPOA1_SULSO

UniProt

Q980R2 - RPOA1_SULSO

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Protein

DNA-directed RNA polymerase subunit A'

Gene

rpoA1

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Zn2+By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri58 – 10144C4-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit A' (EC:2.7.7.6)
Gene namesi
Name:rpoA1
Ordered Locus Names:SSO0225
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 880880DNA-directed RNA polymerase subunit A'PRO_0000074008Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-60638N.
STRINGi273057.SSO0225.

Structurei

Secondary structure

1
880
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 216Combined sources
Beta strandi47 – 493Combined sources
Beta strandi58 – 614Combined sources
Turni84 – 863Combined sources
Helixi87 – 937Combined sources
Beta strandi99 – 1024Combined sources
Turni108 – 1125Combined sources
Helixi114 – 1174Combined sources
Helixi124 – 13815Combined sources
Turni143 – 1453Combined sources
Helixi177 – 1848Combined sources
Helixi189 – 1968Combined sources
Turni199 – 2013Combined sources
Turni204 – 2063Combined sources
Beta strandi207 – 2115Combined sources
Helixi217 – 2193Combined sources
Helixi234 – 25320Combined sources
Beta strandi254 – 2563Combined sources
Turni259 – 2613Combined sources
Helixi262 – 27716Combined sources
Beta strandi282 – 2843Combined sources
Helixi298 – 3003Combined sources
Helixi309 – 3124Combined sources
Beta strandi314 – 3174Combined sources
Beta strandi322 – 3287Combined sources
Beta strandi330 – 3323Combined sources
Beta strandi334 – 3396Combined sources
Helixi343 – 3464Combined sources
Beta strandi347 – 3504Combined sources
Turni355 – 3573Combined sources
Helixi358 – 36710Combined sources
Turni368 – 3703Combined sources
Beta strandi371 – 3733Combined sources
Turni394 – 3963Combined sources
Helixi397 – 4004Combined sources
Beta strandi406 – 4105Combined sources
Beta strandi416 – 4205Combined sources
Helixi427 – 4293Combined sources
Beta strandi430 – 4378Combined sources
Beta strandi439 – 4457Combined sources
Helixi447 – 4493Combined sources
Helixi450 – 4534Combined sources
Turni457 – 4593Combined sources
Beta strandi461 – 4655Combined sources
Helixi470 – 47910Combined sources
Helixi483 – 4853Combined sources
Turni489 – 4924Combined sources
Beta strandi493 – 4964Combined sources
Helixi501 – 5099Combined sources
Helixi518 – 5236Combined sources
Beta strandi541 – 5433Combined sources
Helixi548 – 5525Combined sources
Turni553 – 5553Combined sources
Beta strandi562 – 5643Combined sources
Helixi571 – 5733Combined sources
Beta strandi581 – 5833Combined sources
Beta strandi585 – 5917Combined sources
Helixi600 – 6034Combined sources
Turni607 – 6093Combined sources
Helixi611 – 6177Combined sources
Helixi623 – 6308Combined sources
Helixi632 – 6398Combined sources
Turni640 – 6423Combined sources
Turni649 – 6513Combined sources
Helixi657 – 6626Combined sources
Helixi665 – 68016Combined sources
Helixi692 – 71524Combined sources
Turni716 – 7183Combined sources
Helixi724 – 7285Combined sources
Beta strandi729 – 7346Combined sources
Helixi737 – 7448Combined sources
Beta strandi760 – 7634Combined sources
Beta strandi778 – 7803Combined sources
Turni786 – 7883Combined sources
Helixi794 – 81118Combined sources
Helixi813 – 82412Combined sources
Beta strandi841 – 8433Combined sources
Beta strandi845 – 8495Combined sources
Helixi850 – 8523Combined sources
Helixi857 – 8593Combined sources
Beta strandi860 – 8645Combined sources
Helixi867 – 8748Combined sources
Turni875 – 8773Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PMZX-ray3.40A/Q1-880[»]
3HKZX-ray3.40A/I1-880[»]
ProteinModelPortaliQ980R2.
SMRiQ980R2. Positions 4-879.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980R2.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri58 – 10144C4-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG0086.
HOGENOMiHOG000222974.
InParanoidiQ980R2.
KOiK03041.
OMAiYFFHAMG.

Family and domain databases

InterProiIPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
IPR012758. RNAP_A1.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02390. RNA_pol_rpoA1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q980R2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEKNIKGIK FGILSPDEIR KMSVTAIITP DVYDEDGTPI EGSVMDPRLG
60 70 80 90 100
VIEPGQKCPT CGNTLGNCPG HFGHIELVRP VIHVGLVKHI YEFLKATCRR
110 120 130 140 150
CGRVKISEDE IEKYSRIYNA IKKRWPSAAR RLTEYVKKTA MKAQVCPHCN
160 170 180 190 200
EKQYKIKLEK PYNFYEERKE GVAKLTPSDI RERLEKIPDS DVEILGYDPT
210 220 230 240 250
TSRPEWMILT VLPVPPITIR PSIMIESGIR AEDDLTHKLV DIVRINERLK
260 270 280 290 300
ESIDAGAPQL IIEDLWDLLQ YHVATYFDNE IPGLPPSKHR SGRPLRTLAQ
310 320 330 340 350
RLKGKEGRFR GNLSGKRVDF SSRTVISPDP NISIDEVGVP EIIAKTLTVP
360 370 380 390 400
ERITPWNIEK LRQFVINGPD KWPGANYVIR PDGRRIDLRY VKDRKELAST
410 420 430 440 450
LAPGYIIERH LIDGDIVLFN RQPSLHRISM MAHRVRVLKG LTFRLNLLVC
460 470 480 490 500
PPYNADFDGD EMNLHVPQSE EAIAEAKEIM LVHKNIITPR YGGPIIGAAQ
510 520 530 540 550
DYISGAYLLT VKTTLLTKEE AQQILGVADV KIDLGEPAIL APREYYTGKQ
560 570 580 590 600
VISAFLPKDF NFHGQANVSS GPRLCKNEDC PHDSYVVIKN GILLEGVFDK
610 620 630 640 650
KAIGNQQPES ILHWLIKEYS DEYGKWLMDN LFRVFIRFVE LQGFTMRLED
660 670 680 690 700
VSLGDDVKKE IYNEIDRAKV EVDNLIQKYK NGELEPIPGR TLEESLENYI
710 720 730 740 750
LDTLDKLRST AGDIASKYLD PFNFAYVMAR TGARGSVLNI TQMAAMLGQQ
760 770 780 790 800
SVRGERIKRG YMTRTLPHFK PYDISPEARG FIYSSFRTGL KPTELFFHAA
810 820 830 840 850
GGREGLVDTA VRTSQSGYMQ RRLINALSDL RAEYDGTVRS LYGEVVQVAY
860 870 880
GDDGVFPMYS AHGKTVDVNR IFERVVGWKA
Length:880
Mass (Da):99,675
Last modified:October 1, 2001 - v1
Checksum:i5C8AE20EFC71DE25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40566.1.
PIRiG90163.
RefSeqiNP_341776.1. NC_002754.1.
WP_009990476.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40566; AAK40566; SSO0225.
GeneIDi1455376.
KEGGisso:SSO0225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40566.1 .
PIRi G90163.
RefSeqi NP_341776.1. NC_002754.1.
WP_009990476.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PMZ X-ray 3.40 A/Q 1-880 [» ]
3HKZ X-ray 3.40 A/I 1-880 [» ]
ProteinModelPortali Q980R2.
SMRi Q980R2. Positions 4-879.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60638N.
STRINGi 273057.SSO0225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK40566 ; AAK40566 ; SSO0225 .
GeneIDi 1455376.
KEGGi sso:SSO0225.

Phylogenomic databases

eggNOGi COG0086.
HOGENOMi HOG000222974.
InParanoidi Q980R2.
KOi K03041.
OMAi YFFHAMG.

Enzyme and pathway databases

BioCyci SSOL273057:GCH2-213-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q980R2.

Family and domain databases

InterProi IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
IPR012758. RNAP_A1.
[Graphical view ]
Pfami PF04997. RNA_pol_Rpb1_1. 1 hit.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 1 hit.
[Graphical view ]
SMARTi SM00663. RPOLA_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02390. RNA_pol_rpoA1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.
  2. "The X-ray crystal structure of RNA polymerase from Archaea."
    Hirata A., Klein B.J., Murakami K.S.
    Nature 451:851-854(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE RNA POLYMERASE COMPLEX.

Entry informationi

Entry nameiRPOA1_SULSO
AccessioniPrimary (citable) accession number: Q980R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3