ID   RPO2_SACS2              Reviewed;        1124 AA.
AC   Q980R1; Q980R0;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 133.
DE   RecName: Full=DNA-directed RNA polymerase subunit Rpo2 {ECO:0000305};
DE            EC=2.7.7.6 {ECO:0000305|PubMed:18235446};
DE   AltName: Full=DNA-directed RNA polymerase subunit B {ECO:0000303|PubMed:18235446};
GN   Name=rpo2 {ECO:0000305};
GN   Synonyms=rpoB1 {ECO:0000303|PubMed:11427726}, rpoB2
GN   {ECO:0000303|PubMed:11427726}; OrderedLocusNames=SSO0227/SSO3254;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN   [2] {ECO:0007744|PDB:2PMZ, ECO:0007744|PDB:3HKZ}
RP   X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 479-1124 OF THE RNA POLYMERASE
RP   COMPLEX IN COMPLEX WITH ZINC, SEQUENCE REVISION, FUNCTION, COFACTOR, AND
RP   SUBUNIT.
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=18235446; DOI=10.1038/nature06530;
RA   Hirata A., Klein B.J., Murakami K.S.;
RT   "The X-ray crystal structure of RNA polymerase from Archaea.";
RL   Nature 451:851-854(2008).
CC   -!- FUNCTION: DNA-dependent RNA polymerase (RNAP) catalyzes the
CC       transcription of DNA into RNA using the four ribonucleoside
CC       triphosphates as substrates (Probable). This subunit is involved in DNA
CC       promoter recognition (By similarity). {ECO:0000250|UniProtKB:B8YB55,
CC       ECO:0000305|PubMed:18235446}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000305|PubMed:18235446};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000269|PubMed:18235446};
CC       Note=Binds 1 Zn(2+) per subunit. {ECO:0000269|PubMed:18235446};
CC   -!- SUBUNIT: Part of the 13-subunit RNA polymerase complex.
CC       {ECO:0000269|PubMed:18235446}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B8YB55}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta chain family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK40567.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=AAK40568.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006641; AAK40568.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE006641; AAK40567.1; ALT_FRAME; Genomic_DNA.
DR   PIR; A99164; A99164.
DR   PIR; H90163; H90163.
DR   PDB; 2PMZ; X-ray; 3.40 A; B/R=5-1124.
DR   PDB; 3HKZ; X-ray; 3.40 A; B/J=5-1119.
DR   PDBsum; 2PMZ; -.
DR   PDBsum; 3HKZ; -.
DR   AlphaFoldDB; Q980R1; -.
DR   SMR; Q980R1; -.
DR   DIP; DIP-60640N; -.
DR   IntAct; Q980R1; 1.
DR   STRING; 273057.SSO3254; -.
DR   PaxDb; 273057-SSO0227; -.
DR   EnsemblBacteria; AAK40567; AAK40567; SSO0227.
DR   EnsemblBacteria; AAK40568; AAK40568; SSO3254.
DR   KEGG; sso:SSO0227; -.
DR   KEGG; sso:SSO3254; -.
DR   PATRIC; fig|273057.12.peg.223; -.
DR   eggNOG; arCOG01762; Archaea.
DR   HOGENOM; CLU_000524_2_2_2; -.
DR   InParanoid; Q980R1; -.
DR   PhylomeDB; Q980R1; -.
DR   BRENDA; 2.7.7.6; 6163.
DR   EvolutionaryTrace; Q980R1; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IDA:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032549; F:ribonucleoside binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00653; RNA_pol_B_RPB2; 1.
DR   Gene3D; 2.40.50.150; -; 1.
DR   Gene3D; 3.90.1070.20; -; 1.
DR   Gene3D; 3.90.1100.10; -; 1.
DR   Gene3D; 2.40.270.10; DNA-directed RNA polymerase, subunit 2, domain 6; 1.
DR   Gene3D; 3.90.1800.10; RNA polymerase alpha subunit dimerisation domain; 1.
DR   Gene3D; 3.90.1110.10; RNA polymerase Rpb2, domain 2; 1.
DR   InterPro; IPR015712; DNA-dir_RNA_pol_su2.
DR   InterPro; IPR007120; DNA-dir_RNAP_su2_dom.
DR   InterPro; IPR037033; DNA-dir_RNAP_su2_hyb_sf.
DR   InterPro; IPR007121; RNA_pol_bsu_CS.
DR   InterPro; IPR007644; RNA_pol_bsu_protrusion.
DR   InterPro; IPR007642; RNA_pol_Rpb2_2.
DR   InterPro; IPR037034; RNA_pol_Rpb2_2_sf.
DR   InterPro; IPR007645; RNA_pol_Rpb2_3.
DR   InterPro; IPR007646; RNA_pol_Rpb2_4.
DR   InterPro; IPR007647; RNA_pol_Rpb2_5.
DR   InterPro; IPR007641; RNA_pol_Rpb2_7.
DR   InterPro; IPR014724; RNA_pol_RPB2_OB-fold.
DR   InterPro; IPR019969; RNAP_Rpo2.
DR   NCBIfam; TIGR03670; rpoB_arch; 1.
DR   PANTHER; PTHR20856; DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2; 1.
DR   PANTHER; PTHR20856:SF7; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2; 1.
DR   Pfam; PF04563; RNA_pol_Rpb2_1; 1.
DR   Pfam; PF04561; RNA_pol_Rpb2_2; 1.
DR   Pfam; PF04565; RNA_pol_Rpb2_3; 1.
DR   Pfam; PF04566; RNA_pol_Rpb2_4; 1.
DR   Pfam; PF04567; RNA_pol_Rpb2_5; 1.
DR   Pfam; PF00562; RNA_pol_Rpb2_6; 1.
DR   Pfam; PF04560; RNA_pol_Rpb2_7; 1.
DR   SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
DR   PROSITE; PS01166; RNA_POL_BETA; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA-binding; DNA-directed RNA polymerase;
KW   Metal-binding; Nucleotidyltransferase; Reference proteome; Transcription;
KW   Transferase; Zinc.
FT   CHAIN           1..1124
FT                   /note="DNA-directed RNA polymerase subunit Rpo2"
FT                   /id="PRO_0000453793"
FT   BINDING         1061
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000269|PubMed:18235446,
FT                   ECO:0007744|PDB:2PMZ, ECO:0007744|PDB:3HKZ"
FT   BINDING         1064
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000269|PubMed:18235446,
FT                   ECO:0007744|PDB:2PMZ, ECO:0007744|PDB:3HKZ"
FT   BINDING         1079
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000269|PubMed:18235446,
FT                   ECO:0007744|PDB:2PMZ, ECO:0007744|PDB:3HKZ"
FT   BINDING         1082
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250|UniProtKB:B8YB55"
FT   HELIX           8..18
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           28..36
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            40..43
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            53..55
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          57..60
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          73..75
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           82..85
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            86..89
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          93..96
FT                   /evidence="ECO:0007829|PDB:3HKZ"
FT   STRAND          99..106
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          118..120
FT                   /evidence="ECO:0007829|PDB:3HKZ"
FT   STRAND          126..128
FT                   /evidence="ECO:0007829|PDB:3HKZ"
FT   HELIX           129..132
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           135..141
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           154..156
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          159..161
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          169..175
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          181..183
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          186..191
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          194..196
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          201..206
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            207..210
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          211..213
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          215..217
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          219..222
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           223..229
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           235..242
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           250..252
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           255..258
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          264..266
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            267..269
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           270..273
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           282..284
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           287..294
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          295..297
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            305..308
FT                   /evidence="ECO:0007829|PDB:3HKZ"
FT   HELIX           309..311
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           312..322
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            323..327
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           346..372
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          374..377
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           381..383
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            387..391
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           392..395
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            396..398
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          404..406
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          411..413
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           418..427
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            450..452
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            462..466
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          476..478
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            483..485
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           486..490
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            491..493
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          495..497
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          520..524
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          526..529
FT                   /evidence="ECO:0007829|PDB:3HKZ"
FT   HELIX           536..543
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            544..547
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          554..557
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          566..569
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          572..575
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          577..581
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          583..585
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           591..595
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           604..609
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          612..616
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           621..623
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           630..633
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            644..647
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           651..653
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           663..672
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           673..675
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            682..686
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          690..693
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          702..704
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            707..711
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           713..715
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          718..722
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            734..736
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          740..742
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           743..746
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            747..750
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          754..760
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          765..768
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          778..782
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           789..791
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          803..805
FT                   /evidence="ECO:0007829|PDB:3HKZ"
FT   STRAND          809..811
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          845..854
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          860..867
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          877..879
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          887..892
FT                   /evidence="ECO:0007829|PDB:3HKZ"
FT   TURN            894..896
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          897..899
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          907..910
FT                   /evidence="ECO:0007829|PDB:3HKZ"
FT   HELIX           912..914
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           916..918
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           923..931
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          934..938
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           950..959
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          970..972
FT                   /evidence="ECO:0007829|PDB:3HKZ"
FT   TURN            973..975
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          988..994
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           997..999
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            1011..1013
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           1020..1022
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          1027..1029
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           1030..1032
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           1034..1037
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            1038..1040
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            1042..1053
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          1057..1061
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            1062..1064
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           1073..1075
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   TURN            1083..1086
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   STRAND          1088..1092
FT                   /evidence="ECO:0007829|PDB:2PMZ"
FT   HELIX           1095..1106
FT                   /evidence="ECO:0007829|PDB:2PMZ"
SQ   SEQUENCE   1124 AA;  126552 MW;  03FED53462D84CFF CRC64;
     MASNLTIDER WRVIEAYFKS KGLVRQHLDS YNDFVRNKLQ EIIDEQGEIP TEIPGLKVRL
     GKIRIGKPRV RESDRGEREI SPMEARLRNL TYAAPLWLTM IPVENNIEAE PEEVYIGDLP
     IMLKSAIDPI SQYTLDKLIE IGEDPKDPGG YFIVNGSERV IVTQEDLAPN RVLVDTGKTG
     SNITHTAKII SSTAGYRVPV TIERLKDGTF HVSFPAVPGK IPFVILMRAL GILTDRDIVY
     AVSLDPEVQN ELFPSLEQAS SIANVDDALD FIGSRVAIGQ KRENRIEKAQ QIIDKYFLPH
     LGTSAEDRKK KAYYLAYAIS KVIELYLGRR EPDDKDHYAN KRLRLAGDLF ASLFRVAFKA
     FVKDLTYQLE KSKVRGRKLA LKALVRPDIV TERIRHALAT GNWVGGRTGV SQLLDRTNWL
     SMLSHLRRVI SSLARGQPNF EARDLHGTQW GRMCPFETPE GPNSGLVKNL ALMAQIAVGI
     NERIVEKTLY EMGVVPVEEV IRRVTEGGED QNEYLKWSKV ILNGRLIGYY QDGGELANKI
     RERRRKGEIS DEVNVGHIVT DFINEVHVNC DSGRVRRPLI IVSNGNPLVT IEDIEKLESG
     AITFDDLVRQ GKIEYLDAEE EENAYVALEP NDLTPDHTHL EIWSPAILGI TASIIPYPEH
     NQSPRNTYQS AMAKQALGLY AANYQLRTDT RAHLLHYPQR PLVQTRALDI IGYTNRPAGN
     NAILAVMSFT GYNMEDSIIM NRSSVERGMY RSTFFRLYST EEVKYPGGQE DKIVMPEAGV
     RGYKGKEYYR LLEDNGVVSP EVEVKGGDVL IGKVSPPRFL QEFKELSPEQ AKRDTSIVTR
     HGEMGIVDLV LITETAEGNK LVKVRVRDLR IPTIGDKFAS RHGQKGVIGM LIPQVDMPYT
     VKGVVPDIIL NPHALPSRMT LGQIMEGIAG KYAALSGNIV DATPFYKTPI EQLQNEILRY
     GYLPDATEVV YDGRTGQKIK SRIYFGVVYY QKLHHMVADK LHARARGPVQ ILTRQPTEGR
     AREGGLRFGE MERDCLIGFG TAMLLKDRLL DNSDRTMIYV CDQCGYIGWY DKNKNKYVCP
     IHGDKSNLFP VTVSYAFKLL IQELMSMIIS PRLVLEDKVG LSGG
//