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Q980P5 (Q980P5_SULSO) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenylosuccinate synthetase HAMAP MF_00011
Short name=AMPSase HAMAP MF_00011
Short name=AdSS HAMAP MF_00011
EC=6.3.4.4 HAMAP MF_00011
Alternative name(s):
IMP--aspartate ligase HAMAP MF_00011
Gene names
Name:purA HAMAP MF_00011
Ordered Locus Names:SSO0242
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) EMBL AAK40583.1
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP By similarity. HAMAP MF_00011

Catalytic activity

GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. HAMAP MF_00011

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00011

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. HAMAP MF_00011

Subunit structure

Homodimer By similarity. HAMAP MF_00011

Subcellular location

Cytoplasm By similarity HAMAP MF_00011.

Sequence similarities

Belongs to the adenylosuccinate synthetase family. HAMAP MF_00011

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 177GTP By similarity HAMAP MF_00011
Nucleotide binding40 – 423GTP By similarity HAMAP MF_00011
Nucleotide binding279 – 2813GTP By similarity HAMAP MF_00011
Nucleotide binding319 – 3213GTP By similarity HAMAP MF_00011
Region12 – 154IMP binding By similarity HAMAP MF_00011
Region38 – 414IMP binding By similarity HAMAP MF_00011
Region247 – 2537Substrate binding By similarity HAMAP MF_00011

Sites

Active site121Proton acceptor By similarity HAMAP MF_00011
Active site411Proton donor By similarity HAMAP MF_00011
Metal binding121Magnesium By similarity HAMAP MF_00011
Metal binding401Magnesium; via carbonyl oxygen By similarity HAMAP MF_00011
Binding site1221IMP By similarity HAMAP MF_00011
Binding site1361IMP; shared with dimeric partner By similarity HAMAP MF_00011
Binding site1741IMP By similarity HAMAP MF_00011
Binding site1891IMP By similarity HAMAP MF_00011
Binding site2511IMP By similarity HAMAP MF_00011
Binding site2531GTP By similarity HAMAP MF_00011

Sequences

Sequence LengthMass (Da)Tools
Q980P5 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: C01E75900BEF1918

FASTA33537,440
        10         20         30         40         50         60 
MLELIIGGFF GDEGKGKVAA YLGIKDRPKL SVRTGSINAG HTVTYSGRIW KLRIIPSAFI 

        70         80         90        100        110        120 
NKSTELALGP GALTSLDALF KEMRETETYD RLYIDSHVGI ITEDEIRDEK NDPYLMNVIG 

       130        140        150        160        170        180 
STGQGVGYAE SKRILRKLKL AKDYKELEKF IIDVPNKILD YLDNGHNILI EGTQGHYLSL 

       190        200        210        220        230        240 
YHGEYPYVTS RNTTASGVLS EAGIGPKYVD HIIITFKSYV TRVGKGPLEG ELTEEDAKKL 

       250        260        270        280        290        300 
GLTEYGTVTG RLRRVAPFNV KLAREAIRIN SATIVAITKL DTLFKDAYRV REYEKLPAEA 

       310        320        330 
RKWLDELEEE LKTPIGLIGT GEDAYDMIDL REEVG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE006641 Genomic DNA. Translation: AAK40583.1.
PIRH90165.
RefSeqNP_341793.1. NC_002754.1.

3D structure databases

HSSPHSSP built from PDB template 1ADE based on UniProtKB P12283.
ProteinModelPortalQ980P5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1455393.
GenomeReviewsGene locus SSO0242 in contig AE006641_GR.
KEGGsso:SSO0242.
NMPDRfig|273057.1.peg.216.

Phylogenomic databases

HOGENOMHBG658237.
OMAIDPHVGI.
ProtClustDBPRK04293.

Enzyme and pathway databases

BioCycSSOL273057:SSO0242-MONOMER.

Family and domain databases

HAMAPMF_00011. Adenylosucc_synth.
[Tree]
InterProIPR018220. Adenylosuccinate_synthase_AS.
IPR001114. Adenylosuccinate_synthetase.
[Graphical view]
KOK01939.
PANTHERPTHR11846. Asucc_synthtase. 1 hit.
PfamPF00709. Adenylsucc_synt. 3 hits.
[Graphical view]
SMARTSM00788. Adenylsucc_synt. 1 hit.
[Graphical view]
PROSITEPS01266. ADENYLOSUCCIN_SYN_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ980P5_SULSO
AccessionPrimary (citable) accession number: Q980P5
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2001
Last sequence update: October 1, 2001
Last modified: January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info