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Protein

ORC1-type DNA replication protein 1

Gene

cdc6-1

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds to DNA, with a preference for molecules that contain a bubble, a fork, or a tail. Inhibits the binding of the MCM helicase to the origin DNA and strongly inhibits its DNA helicase activity. Also regulates the DNA polymerase and the nuclease activities of PolB1. Stimulates the DNA-binding activity of Cdc6-3.UniRule annotation4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei208ATPUniRule annotation1
Binding sitei220ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 71ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ORC1-type DNA replication protein 1UniRule annotation
Gene namesi
Name:cdc6-1
Ordered Locus Names:SSO0257
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510181 – 397ORC1-type DNA replication protein 1Add BLAST397

Post-translational modificationi

Autophosphorylated in vitro.

Proteomic databases

PRIDEiQ980N4.

Interactioni

Subunit structurei

Monomer. Interacts with Cdc6-3, MCM and PolB1.5 Publications

Protein-protein interaction databases

DIPiDIP-48851N.
STRINGi273057.SSO0257.

Structurei

Secondary structure

1397
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 24Combined sources4
Beta strandi25 – 27Combined sources3
Helixi37 – 45Combined sources9
Helixi48 – 52Combined sources5
Beta strandi59 – 63Combined sources5
Helixi69 – 83Combined sources15
Beta strandi89 – 94Combined sources6
Helixi95 – 98Combined sources4
Helixi101 – 108Combined sources8
Turni109 – 112Combined sources4
Beta strandi118 – 120Combined sources3
Helixi123 – 135Combined sources13
Beta strandi141 – 146Combined sources6
Helixi148 – 153Combined sources6
Helixi159 – 168Combined sources10
Beta strandi175 – 182Combined sources8
Helixi184 – 189Combined sources6
Helixi193 – 196Combined sources4
Turni197 – 200Combined sources4
Beta strandi201 – 205Combined sources5
Helixi210 – 224Combined sources15
Helixi232 – 244Combined sources13
Helixi249 – 265Combined sources17
Helixi273 – 293Combined sources21
Helixi297 – 309Combined sources13
Helixi319 – 333Combined sources15
Helixi340 – 352Combined sources13
Beta strandi355 – 360Combined sources6
Beta strandi370 – 376Combined sources7
Helixi379 – 388Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QBYX-ray3.35A15-397[»]
ProteinModelPortaliQ980N4.
SMRiQ980N4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980N4.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC6/cdc18 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00467. Archaea.
COG1474. LUCA.
HOGENOMiHOG000230140.
InParanoidiQ980N4.
KOiK10725.
OMAiTGWPTDQ.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01407. ORC1_type_DNA_replic_protein. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C.
IPR014277. Orc1/Cdc6_arc.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13401. AAA_22. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02928. TIGR02928. 1 hit.

Sequencei

Sequence statusi: Complete.

Q980N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIIDEVIS SFKTSSIFIN REYLLPDYIP DELPHREDQI RKIASILAPL
60 70 80 90 100
YREEKPNNIF IYGLTGTGKT AVVKFVLSKL HKKFLGKFKH VYINTRQIDT
110 120 130 140 150
PYRVLADLLE SLDVKVPFTG LSIAELYRRL VKAVRDYGSQ VVIVLDEIDA
160 170 180 190 200
FVKKYNDDIL YKLSRINSEV NKSKISFIGI TNDVKFVDLL DPRVKSSLSE
210 220 230 240 250
EEIIFPPYNA EELEDILTKR AQMAFKPGVL PDNVIKLCAA LAAREHGDAR
260 270 280 290 300
RALDLLRVSG EIAERMKDTK VKEEYVYMAK EEIERDRVRD IILTLPFHSK
310 320 330 340 350
LVLMAVVSIS SEENVVSTTG AVYETYLNIC KKLGVEAVTQ RRVSDIINEL
360 370 380 390
DMVGILTAKV VNRGRYGKTK EIGLAVDKNI IVRSLIESDS RFADLWS
Length:397
Mass (Da):45,167
Last modified:October 1, 2001 - v1
Checksum:iA2A32A355A3ADD74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40596.1.
PIRiE90167.
RefSeqiWP_009990521.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40596; AAK40596; SSO0257.
GeneIDi27426550.
KEGGisso:SSO0257.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40596.1.
PIRiE90167.
RefSeqiWP_009990521.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QBYX-ray3.35A15-397[»]
ProteinModelPortaliQ980N4.
SMRiQ980N4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48851N.
STRINGi273057.SSO0257.

Proteomic databases

PRIDEiQ980N4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40596; AAK40596; SSO0257.
GeneIDi27426550.
KEGGisso:SSO0257.

Phylogenomic databases

eggNOGiarCOG00467. Archaea.
COG1474. LUCA.
HOGENOMiHOG000230140.
InParanoidiQ980N4.
KOiK10725.
OMAiTGWPTDQ.

Miscellaneous databases

EvolutionaryTraceiQ980N4.

Family and domain databases

CDDicd08768. Cdc6_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01407. ORC1_type_DNA_replic_protein. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C.
IPR014277. Orc1/Cdc6_arc.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13401. AAA_22. 1 hit.
PF09079. Cdc6_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02928. TIGR02928. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDC61_SULSO
AccessioniPrimary (citable) accession number: Q980N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.