Q980I7 (AROC_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	SSO0307

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Chorismate synthase HAMAP MF_00300		PRO_0000140697

Sequences

	Sequence		Length	Mass (Da)
	Q980I7 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: CEDE6FC88ADAD5AE	FASTA	391	43,179
	10 20 30 40 50 60 MPGNSFGKLF RITTFGESHG PAVGVVIDGV PAGLPLTVED IKFELEFRRP GRLYVSGRRE 70 80 90 100 110 120 KDEPEILSGI FNNRTTGSPI AVIVRNTDVI SSFYDEIKYK PRPGHADLPF IMKYGYENWD 130 140 150 160 170 180 YRGGGRASAR ETVSRVIAGA VAKKLLMLTD TWIAGHLRSL GPEELSEEVT FEEVLCSKYS 190 200 210 220 230 240 PVRASKKDLE EKYEALIKKA TQEGDSYGGI AEVIAKNPPI GLGEPVFDKM KAELAKAIMS 250 260 270 280 290 300 IPAVMGFEYG LGFIASKMKG SEANDEIIRK NNRIGWKYNY AGGILGGLTN GEDLIVRCAF 310 320 330 340 350 360 KPTSSIRKPQ KTIDLRNLEE SYISVIGRHD PAVAIRGVTV VESMVALTIV DHAMRAGAIP 370 380 390 LVKLTEDQAN TIQQRWERYV KSCKPMEESQ S

References

[1]

"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006641 Genomic DNA. Translation: AAK40644.1.
PIR	E90173.
RefSeq	NP_341854.1. NC_002754.1.
3D structure databases
ProteinModelPortal	Q980I7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1455454.
GenomeReviews	Gene locus SSO0307 in contig AE006641_GR.
KEGG	sso:SSO0307.
NMPDR	fig|273057.1.peg.277.
Phylogenomic databases
HOGENOM	HBG292336.
OMA	AQLAHAM.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0307-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_SULSO

Accession

Primary (citable) accession number: Q980I7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	October 1, 2001
Last modified:	December 14, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program