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Q980E8 (GCH1_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:SSO0364
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119475

Sites

Metal binding891Zinc By similarity
Metal binding921Zinc By similarity
Metal binding1631Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q980E8 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: EA37486D88C543B1

FASTA20823,578
        10         20         30         40         50         60 
MQKTELDDQK LVEEIARRIR EILELLGENP EREGLKETPE RVAKALLEMT SGLRTPPPQI 

        70         80         90        100        110        120 
KVFNLGDDGE VYEKNQIVLI KDVNFSSLCE HHMLPIIGKI HVAYIVSNSG KVAGFSKIIR 

       130        140        150        160        170        180 
IVNYYSSRLQ IQERLVEQIA DAIMNSEIKP KGVMVIGNAI HMCSYVRGVK DKEAKLVSVA 

       190        200 
YRGLFKTNRA LQNHVFRLLD NANKVNLL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK40694.1.
PIRG90179.
RefSeqNP_341904.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ980E8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0364.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40694; AAK40694; SSO0364.
GeneID1455504.
KEGGsso:SSO0364.

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMARKPGAVT.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-347-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_SULSO
AccessionPrimary (citable) accession number: Q980E8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways