Q980C3 (TRUB_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tRNA pseudouridine synthase B
EC=5.4.99.25

Alternative name(s):
tRNA pseudouridine(55) synthase
Short name=Psi55 synthase
tRNA pseudouridylate synthase
tRNA-uridine isomerase

Gene names

Name:	truB
Ordered Locus Names:	SSO0393

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs By similarity. HAMAP MF_01081
Catalytic activity	tRNA uridine(55) = tRNA pseudouridine(55). HAMAP MF_01081
Sequence similarities	Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. Contains 1 PUA domain.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pseudouridine synthesis Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro pseudouridine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Probable tRNA pseudouridine synthase B HAMAP MF_01081		PRO_0000121971
Regions
	Domain	163 – 237	75	PUA

Sequences

	Sequence		Length	Mass (Da)
	Q980C3 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: FA184048749B5328	FASTA	251	28,668
	10 20 30 40 50 60 MLPIGIENAT KIMNYISKGG KEYVCVMQVH CEYNKEELAK IISSFKGEIY QRPPVRSSVK 70 80 90 100 110 120 RRLRIRRIYD IEILDMDKKL VLLRVNCDSG TYMRKLCHDI GIIYGCGAHM RELRRTRSGI 130 140 150 160 170 180 FTESTNLVKL HELSEAIYLY KNCKDETELR RVLIPMEFAT CEIPKIVIED SAVNALAYGA 190 200 210 220 230 240 QLAVPGVVAY QNFKKNDTVA VLTLKGELVA TGNALMDSEE LENAKKGIVV NLSRVFMQRD 250 IYPKAWKKHE S

References

[1]

"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006641 Genomic DNA. Translation: AAK40720.1.
PIR	A99183.
RefSeq	NP_341930.2. NC_002754.1.
3D structure databases
ProteinModelPortal	Q980C3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1455530.
GenomeReviews	Gene locus SSO0393 in contig AE006641_GR.
KEGG	sso:SSO0393.
NMPDR	fig|273057.1.peg.353.
Phylogenomic databases
HOGENOM	HBG397258.
OMA	IYQRPPL.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO0393-MONOMER.
Family and domain databases
HAMAP	MF_01081. TruB_arch. Divergent sequence. [Tree]
InterPro	IPR002501. PsdUridine_synth. IPR020103. PsdUridine_synth_cat_dom. IPR004802. Pseudouridine_synthase-related. IPR002478. PUA. IPR015947. PUA-like_domain. IPR004521. Uncharacterised_CHP00451. [Graphical view]
KO	K03177.
PANTHER	PTHR23127. PTHR23127. 1 hit.
Pfam	PF01472. PUA. 1 hit. PF01509. TruB_N. 1 hit. [Graphical view]
SMART	SM00359. PUA. 1 hit. [Graphical view]
SUPFAM	SSF55120. PsdUridine_synth_cat_dom. 1 hit. SSF88697. PUA-like. 1 hit.
TIGRFAMs	TIGR00425. CBF5. 1 hit. TIGR00451. Unchar_dom_2. 1 hit.
PROSITE	PS50890. PUA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRUB_SULSO

Accession

Primary (citable) accession number: Q980C3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	October 1, 2001
Last modified:	December 14, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program