Q980A9 (METE_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable methylcobalamin:homocysteine methyltransferase
EC=2.1.1.-

Alternative name(s):
Methionine synthase

Gene names

Name:	metE
Ordered Locus Names:	SSO0407

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus solfataricus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from methylcobalamin and methylcobinamide to homocysteine resulting in methionine formation By similarity. HAMAP-Rule MF_00288
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway. HAMAP-Rule MF_00288
Sequence similarities	Belongs to the vitamin-B12 independent methionine synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	methionine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Probable methylcobalamin:homocysteine methyltransferase HAMAP-Rule MF_00288		PRO_0000098692
Sites
	Metal binding	211	1	Zinc By similarity
	Metal binding	213	1	Zinc By similarity
	Metal binding	296	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q980A9 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 88D4CF48846B1C2B	FASTA	332	38,250
	10 20 30 40 50 60 MSKLPLLPTT VIGSYPRPKW LRESIRLHKA GKMSNEDLQE AFNDAVIAVF QDHYKAGVDV 70 80 90 100 110 120 PTDGEVRRDE MVEFFAERIK GFKFYGPVRV WGTAYYRKPS VVSKIEYREP MLVDEFTFAK 130 140 150 160 170 180 SVSYTDNLKI TITGPYTIAE WSYNEYYRNK KDLVFDLAKA INQEIKNLVE AGAKIIQIDE 190 200 210 220 230 240 PALHTRKEDV SWGVEAVNEA VKGVNAKLVM HICYGDYSFV APYFNEIKVD QINFALKIYN 250 260 270 280 290 300 YKPLELLKKY GFDKELGAGV VDVHNRKVET SEEVANDIRK ILEYFPPEKV WINPDCGLKL 310 320 330 LSRKIAYQKL VSMVEGTKVV REELKRKGYS VD

References

[1]

"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006641 Genomic DNA. Translation: AAK40736.1.
PIR	A99185.
RefSeq	NP_341946.1. NC_002754.1.
3D structure databases
ProteinModelPortal	Q980A9.
ModBase	Search...
Protein-protein interaction databases
STRING	273057.SSO0407.
Proteomic databases
PRIDE	Q980A9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK40736; AAK40736; SSO0407.
GeneID	1455546.
KEGG	sso:SSO0407.
Phylogenomic databases
eggNOG	COG0620.
HOGENOM	HOG000140559.
KO	K00549.
OMA	GINAKLM.
ProtClustDB	PRK04326.
Enzyme and pathway databases
UniPathway	UPA00051.
Family and domain databases
HAMAP	MF_00288. MetE.
InterPro	IPR022921. MetE_arc. IPR002629. Methionine_synth. [Graphical view]
Pfam	PF01717. Meth_synt_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

METE_SULSO

Accession

Primary (citable) accession number: Q980A9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 1, 2001
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program