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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238GTPUniRule annotation
Nucleotide bindingi93 – 975GTPUniRule annotation
Nucleotide bindingi149 – 1524GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-397-MONOMER.
BRENDAi3.6.5.3. 6163.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gammaUniRule annotation
Alternative name(s):
aIF2-gammaUniRule annotation
eIF-2-gammaUniRule annotation
Gene namesi
Name:eif2gUniRule annotation
Ordered Locus Names:SSO0412
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Translation initiation factor 2 subunit gammaPRO_0000137463Add
BLAST

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Protein-protein interaction databases

DIPiDIP-29031N.
STRINGi273057.SSO0412.

Structurei

Secondary structure

1
415
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 156Combined sources
Beta strandi18 – 214Combined sources
Helixi22 – 309Combined sources
Turni34 – 374Combined sources
Helixi38 – 436Combined sources
Beta strandi50 – 589Combined sources
Beta strandi60 – 623Combined sources
Turni64 – 674Combined sources
Beta strandi68 – 725Combined sources
Helixi75 – 773Combined sources
Beta strandi84 – 9310Combined sources
Helixi98 – 1003Combined sources
Helixi101 – 1088Combined sources
Beta strandi112 – 1198Combined sources
Beta strandi120 – 1245Combined sources
Helixi127 – 13913Combined sources
Beta strandi144 – 1496Combined sources
Helixi151 – 1533Combined sources
Helixi156 – 17015Combined sources
Turni174 – 1774Combined sources
Beta strandi180 – 1823Combined sources
Turni185 – 1884Combined sources
Helixi191 – 20111Combined sources
Beta strandi209 – 2113Combined sources
Beta strandi214 – 2218Combined sources
Helixi230 – 2323Combined sources
Beta strandi237 – 2459Combined sources
Beta strandi252 – 26312Combined sources
Beta strandi266 – 27510Combined sources
Beta strandi278 – 2814Combined sources
Beta strandi284 – 2896Combined sources
Beta strandi291 – 2933Combined sources
Beta strandi295 – 2984Combined sources
Helixi303 – 3053Combined sources
Helixi307 – 3093Combined sources
Turni310 – 3134Combined sources
Beta strandi315 – 3184Combined sources
Beta strandi325 – 33511Combined sources
Beta strandi337 – 3393Combined sources
Beta strandi342 – 3443Combined sources
Beta strandi356 – 3616Combined sources
Beta strandi364 – 37310Combined sources
Beta strandi375 – 38713Combined sources
Beta strandi390 – 3923Combined sources
Beta strandi393 – 4019Combined sources
Beta strandi404 – 41411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AHOX-ray3.00A2-415[»]
2PLFX-ray2.90A2-415[»]
2PMDX-ray2.65A/B1-415[»]
2QMUX-ray3.20A2-415[»]
2QN6X-ray2.15A2-415[»]
3CW2X-ray2.80A/B/E/F1-415[»]
3I1FX-ray2.50A/B1-415[»]
3PENX-ray2.30A2-415[»]
3QSYX-ray3.20A1-415[»]
3SJZX-ray2.80A2-415[»]
3V11X-ray5.00A2-415[»]
4M0LX-ray2.60A/B/C/D/E/F1-415[»]
4M2LX-ray2.15A1-415[»]
4M4SX-ray2.25A1-415[»]
4M53X-ray2.00A1-415[»]
4NBSX-ray2.30A1-415[»]
4QFMX-ray2.30A1-415[»]
4QHYX-ray3.29A1-415[»]
4RCYX-ray1.65A1-415[»]
4RCZX-ray1.43A1-415[»]
4RD0X-ray1.71A1-415[»]
4RD1X-ray1.50A1-415[»]
4RD2X-ray1.58A1-415[»]
4RD3X-ray1.69A1-415[»]
4RD4X-ray1.30A1-415[»]
4RD6X-ray1.94A1-415[»]
4RJLX-ray1.64A1-415[»]
ProteinModelPortaliQ980A5.
SMRiQ980A5. Positions 2-415.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980A5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 206200tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni16 – 238G1By similarity
Regioni44 – 485G2By similarity
Regioni93 – 964G3By similarity
Regioni149 – 1524G4By similarity
Regioni184 – 1863G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
InParanoidiQ980A5.
KOiK03242.
OMAiIAANEPC.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q980A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWPKVQPEV NIGVVGHVDH GKTTLVQAIT GIWTSKHSEE LKRGMTIKLG
60 70 80 90 100
YAETNIGVCE SCKKPEAYVT EPSCKSCGSD DEPKFLRRIS FIDAPGHEVL
110 120 130 140 150
MATMLSGAAL MDGAILVVAA NEPFPQPQTR EHFVALGIIG VKNLIIVQNK
160 170 180 190 200
VDVVSKEEAL SQYRQIKQFT KGTWAENVPI IPVSALHKIN IDSLIEGIEE
210 220 230 240 250
YIKTPYRDLS QKPVMLVIRS FDVNKPGTQF NELKGGVIGG SIIQGLFKVD
260 270 280 290 300
QEIKVLPGLR VEKQGKVSYE PIFTKISSIR FGDEEFKEAK PGGLVAIGTY
310 320 330 340 350
LDPSLTKADN LLGSIITLAD AEVPVLWNIR IKYNLLERVV GAKEMLKVDP
360 370 380 390 400
IRAKETLMLS VGSSTTLGIV TSVKKDEIEV ELRRPVAVWS NNIRTVISRQ
410
IAGRWRMIGW GLVEI
Length:415
Mass (Da):45,792
Last modified:October 1, 2001 - v1
Checksum:i74A1F3C850D2D3D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40740.1.
PIRiE90185.
RefSeqiWP_009988771.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40740; AAK40740; SSO0412.
GeneIDi27426710.
KEGGisso:SSO0412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40740.1.
PIRiE90185.
RefSeqiWP_009988771.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AHOX-ray3.00A2-415[»]
2PLFX-ray2.90A2-415[»]
2PMDX-ray2.65A/B1-415[»]
2QMUX-ray3.20A2-415[»]
2QN6X-ray2.15A2-415[»]
3CW2X-ray2.80A/B/E/F1-415[»]
3I1FX-ray2.50A/B1-415[»]
3PENX-ray2.30A2-415[»]
3QSYX-ray3.20A1-415[»]
3SJZX-ray2.80A2-415[»]
3V11X-ray5.00A2-415[»]
4M0LX-ray2.60A/B/C/D/E/F1-415[»]
4M2LX-ray2.15A1-415[»]
4M4SX-ray2.25A1-415[»]
4M53X-ray2.00A1-415[»]
4NBSX-ray2.30A1-415[»]
4QFMX-ray2.30A1-415[»]
4QHYX-ray3.29A1-415[»]
4RCYX-ray1.65A1-415[»]
4RCZX-ray1.43A1-415[»]
4RD0X-ray1.71A1-415[»]
4RD1X-ray1.50A1-415[»]
4RD2X-ray1.58A1-415[»]
4RD3X-ray1.69A1-415[»]
4RD4X-ray1.30A1-415[»]
4RD6X-ray1.94A1-415[»]
4RJLX-ray1.64A1-415[»]
ProteinModelPortaliQ980A5.
SMRiQ980A5. Positions 2-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29031N.
STRINGi273057.SSO0412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40740; AAK40740; SSO0412.
GeneIDi27426710.
KEGGisso:SSO0412.

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
InParanoidiQ980A5.
KOiK03242.
OMAiIAANEPC.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-397-MONOMER.
BRENDAi3.6.5.3. 6163.

Miscellaneous databases

EvolutionaryTraceiQ980A5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiIF2G_SULSO
AccessioniPrimary (citable) accession number: Q980A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2001
Last modified: July 6, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.