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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPUniRule annotation8
Nucleotide bindingi93 – 97GTPUniRule annotation5
Nucleotide bindingi149 – 152GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.3. 6163.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gammaUniRule annotation
Alternative name(s):
aIF2-gammaUniRule annotation
eIF-2-gammaUniRule annotation
Gene namesi
Name:eif2gUniRule annotation
Ordered Locus Names:SSO0412
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374631 – 415Translation initiation factor 2 subunit gammaAdd BLAST415

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Protein-protein interaction databases

DIPiDIP-29031N.
STRINGi273057.SSO0412.

Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 15Combined sources6
Beta strandi18 – 21Combined sources4
Helixi22 – 30Combined sources9
Turni34 – 37Combined sources4
Helixi38 – 43Combined sources6
Beta strandi50 – 58Combined sources9
Beta strandi60 – 62Combined sources3
Turni64 – 67Combined sources4
Beta strandi68 – 72Combined sources5
Helixi75 – 77Combined sources3
Beta strandi84 – 93Combined sources10
Helixi98 – 100Combined sources3
Helixi101 – 108Combined sources8
Beta strandi112 – 119Combined sources8
Beta strandi120 – 124Combined sources5
Helixi127 – 139Combined sources13
Beta strandi144 – 149Combined sources6
Helixi151 – 153Combined sources3
Helixi156 – 170Combined sources15
Beta strandi171 – 173Combined sources3
Turni174 – 177Combined sources4
Beta strandi180 – 182Combined sources3
Turni185 – 188Combined sources4
Helixi191 – 201Combined sources11
Beta strandi209 – 211Combined sources3
Beta strandi214 – 221Combined sources8
Helixi230 – 232Combined sources3
Beta strandi237 – 245Combined sources9
Beta strandi252 – 263Combined sources12
Beta strandi266 – 275Combined sources10
Beta strandi278 – 281Combined sources4
Beta strandi284 – 289Combined sources6
Beta strandi291 – 293Combined sources3
Beta strandi295 – 298Combined sources4
Helixi303 – 305Combined sources3
Helixi307 – 309Combined sources3
Turni310 – 313Combined sources4
Beta strandi315 – 318Combined sources4
Beta strandi325 – 335Combined sources11
Beta strandi337 – 339Combined sources3
Beta strandi342 – 344Combined sources3
Beta strandi356 – 361Combined sources6
Beta strandi364 – 373Combined sources10
Beta strandi375 – 387Combined sources13
Beta strandi390 – 392Combined sources3
Beta strandi393 – 401Combined sources9
Beta strandi404 – 414Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AHOX-ray3.00A2-415[»]
2PLFX-ray2.90A2-415[»]
2PMDX-ray2.65A/B1-415[»]
2QMUX-ray3.20A2-415[»]
2QN6X-ray2.15A2-415[»]
3CW2X-ray2.80A/B/E/F1-415[»]
3I1FX-ray2.50A/B1-415[»]
3PENX-ray2.30A2-415[»]
3QSYX-ray3.20A1-415[»]
3SJZX-ray2.80A2-415[»]
3V11X-ray5.00A2-415[»]
4M0LX-ray2.60A/B/C/D/E/F1-415[»]
4M2LX-ray2.15A1-415[»]
4M4SX-ray2.25A1-415[»]
4M53X-ray2.00A1-415[»]
4NBSX-ray2.30A1-415[»]
4QFMX-ray2.30A1-415[»]
4QHYX-ray3.29A1-415[»]
4RCYX-ray1.65A1-415[»]
4RCZX-ray1.43A1-415[»]
4RD0X-ray1.71A1-415[»]
4RD1X-ray1.50A1-415[»]
4RD2X-ray1.58A1-415[»]
4RD3X-ray1.69A1-415[»]
4RD4X-ray1.30A1-415[»]
4RD6X-ray1.94A1-415[»]
4RJLX-ray1.64A1-415[»]
5DSZX-ray2.50A/B1-415[»]
ProteinModelPortaliQ980A5.
SMRiQ980A5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980A5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 206tr-type GAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 23G1By similarity8
Regioni44 – 48G2By similarity5
Regioni93 – 96G3By similarity4
Regioni149 – 152G4By similarity4
Regioni184 – 186G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
InParanoidiQ980A5.
KOiK03242.
OMAiWTDRHSE.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q980A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWPKVQPEV NIGVVGHVDH GKTTLVQAIT GIWTSKHSEE LKRGMTIKLG
60 70 80 90 100
YAETNIGVCE SCKKPEAYVT EPSCKSCGSD DEPKFLRRIS FIDAPGHEVL
110 120 130 140 150
MATMLSGAAL MDGAILVVAA NEPFPQPQTR EHFVALGIIG VKNLIIVQNK
160 170 180 190 200
VDVVSKEEAL SQYRQIKQFT KGTWAENVPI IPVSALHKIN IDSLIEGIEE
210 220 230 240 250
YIKTPYRDLS QKPVMLVIRS FDVNKPGTQF NELKGGVIGG SIIQGLFKVD
260 270 280 290 300
QEIKVLPGLR VEKQGKVSYE PIFTKISSIR FGDEEFKEAK PGGLVAIGTY
310 320 330 340 350
LDPSLTKADN LLGSIITLAD AEVPVLWNIR IKYNLLERVV GAKEMLKVDP
360 370 380 390 400
IRAKETLMLS VGSSTTLGIV TSVKKDEIEV ELRRPVAVWS NNIRTVISRQ
410
IAGRWRMIGW GLVEI
Length:415
Mass (Da):45,792
Last modified:October 1, 2001 - v1
Checksum:i74A1F3C850D2D3D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40740.1.
PIRiE90185.
RefSeqiWP_009988771.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK40740; AAK40740; SSO0412.
GeneIDi27426710.
KEGGisso:SSO0412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK40740.1.
PIRiE90185.
RefSeqiWP_009988771.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AHOX-ray3.00A2-415[»]
2PLFX-ray2.90A2-415[»]
2PMDX-ray2.65A/B1-415[»]
2QMUX-ray3.20A2-415[»]
2QN6X-ray2.15A2-415[»]
3CW2X-ray2.80A/B/E/F1-415[»]
3I1FX-ray2.50A/B1-415[»]
3PENX-ray2.30A2-415[»]
3QSYX-ray3.20A1-415[»]
3SJZX-ray2.80A2-415[»]
3V11X-ray5.00A2-415[»]
4M0LX-ray2.60A/B/C/D/E/F1-415[»]
4M2LX-ray2.15A1-415[»]
4M4SX-ray2.25A1-415[»]
4M53X-ray2.00A1-415[»]
4NBSX-ray2.30A1-415[»]
4QFMX-ray2.30A1-415[»]
4QHYX-ray3.29A1-415[»]
4RCYX-ray1.65A1-415[»]
4RCZX-ray1.43A1-415[»]
4RD0X-ray1.71A1-415[»]
4RD1X-ray1.50A1-415[»]
4RD2X-ray1.58A1-415[»]
4RD3X-ray1.69A1-415[»]
4RD4X-ray1.30A1-415[»]
4RD6X-ray1.94A1-415[»]
4RJLX-ray1.64A1-415[»]
5DSZX-ray2.50A/B1-415[»]
ProteinModelPortaliQ980A5.
SMRiQ980A5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29031N.
STRINGi273057.SSO0412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40740; AAK40740; SSO0412.
GeneIDi27426710.
KEGGisso:SSO0412.

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
HOGENOMiHOG000229292.
InParanoidiQ980A5.
KOiK03242.
OMAiWTDRHSE.

Enzyme and pathway databases

BRENDAi3.6.5.3. 6163.

Miscellaneous databases

EvolutionaryTraceiQ980A5.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2G_SULSO
AccessioniPrimary (citable) accession number: Q980A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.