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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:SSO0452
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367331 – 380Tryptophan--tRNA ligaseAdd BLAST380

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0452

Structurei

3D structure databases

ProteinModelPortaliQ97ZX0
SMRiQ97ZX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 89"HIGH" region9
Motifi253 – 257"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01887 Archaea
COG0180 LUCA
HOGENOMiHOG000224742
InParanoidiQ97ZX0
KOiK01867
OMAiADILHPQ
OrthoDBiPOG093Z034D

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00140_A Trp_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR020653 Tryptophan-tRNA-ligase_arc
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q97ZX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDEFTVTPW EVKGKVDYDK LIVQFGTQKI TEELKQRIKN LAGDLHVMLR
60 70 80 90 100
RNVFFSHRDL DLVLNDYEKS KGFFLYTGRA PSLGMHIGHL IPFIFTKWLQ
110 120 130 140 150
EKFNANLYIE ITDDEKYMRN PEFTLDQTRS WAYDNILDII AVGFNPDKTF
160 170 180 190 200
IFQDTEYIRN MYPITVKIAK KLTFSEVRAT FGLDASSNIG LIFYPALQIA
210 220 230 240 250
PTMFEKKRCL IPAGIDQDPY WRLQRDIAES LGYYKAAQIH SKFLPPLTGP
260 270 280 290 300
EGKMSSSNPE TAIYLVDDPK TVERKIMKYA FSGGQPTIEL HRKYGGNPEI
310 320 330 340 350
DVPFQWLYYF FEEDDNRIKE IEEEYRSGKM LTGELKQILI DKLNNFLEEH
360 370 380
RRRREEAKEL VHVFKYDGKL AKQMWEKIHE
Length:380
Mass (Da):44,691
Last modified:April 16, 2002 - v2
Checksum:iCF8344CF63883680
GO

Sequence cautioni

The sequence AAK40778 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK40778.1 Different initiation.
PIRiC90190

Genome annotation databases

EnsemblBacteriaiAAK40778; AAK40778; SSO0452
KEGGisso:SSO0452
PATRICifig|273057.12.peg.447

Similar proteinsi

Entry informationi

Entry nameiSYW_SULSO
AccessioniPrimary (citable) accession number: Q97ZX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: March 28, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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