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Q97ZX0 (SYW_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:SSO0452
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence AAK40778.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136733

Regions

Motif81 – 899"HIGH" region HAMAP-Rule MF_00140
Motif253 – 2575"KMSKS" region HAMAP-Rule MF_00140

Sequences

Sequence LengthMass (Da)Tools
Q97ZX0 [UniParc].

Last modified April 16, 2002. Version 2.
Checksum: CF8344CF63883680

FASTA38044,691
        10         20         30         40         50         60 
MPDEFTVTPW EVKGKVDYDK LIVQFGTQKI TEELKQRIKN LAGDLHVMLR RNVFFSHRDL 

        70         80         90        100        110        120 
DLVLNDYEKS KGFFLYTGRA PSLGMHIGHL IPFIFTKWLQ EKFNANLYIE ITDDEKYMRN 

       130        140        150        160        170        180 
PEFTLDQTRS WAYDNILDII AVGFNPDKTF IFQDTEYIRN MYPITVKIAK KLTFSEVRAT 

       190        200        210        220        230        240 
FGLDASSNIG LIFYPALQIA PTMFEKKRCL IPAGIDQDPY WRLQRDIAES LGYYKAAQIH 

       250        260        270        280        290        300 
SKFLPPLTGP EGKMSSSNPE TAIYLVDDPK TVERKIMKYA FSGGQPTIEL HRKYGGNPEI 

       310        320        330        340        350        360 
DVPFQWLYYF FEEDDNRIKE IEEEYRSGKM LTGELKQILI DKLNNFLEEH RRRREEAKEL 

       370        380 
VHVFKYDGKL AKQMWEKIHE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK40778.1. Different initiation.
PIRC90190.
RefSeqNP_341988.2. NC_002754.1.

3D structure databases

ProteinModelPortalQ97ZX0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0452.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK40778; AAK40778; SSO0452.
GeneID1455588.
KEGGsso:SSO0452.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000224742.
KOK01867.
OMAEFVVTPW.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-437-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_A. Trp_tRNA_synth_A.
InterProIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYW_SULSO
AccessionPrimary (citable) accession number: Q97ZX0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: April 16, 2002
Last modified: May 14, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries