Q97ZN1 (SYR_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	SSO0857

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus solfataricus

Protein attributes

Sequence length	625 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 625	625	Arginine--tRNA ligase HAMAP-Rule MF_00123		PRO_0000151656
Regions
	Motif	117 – 127	11	"HIGH" region HAMAP-Rule MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q97ZN1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 38893F7E4602C19F	FASTA	625	71,387
	10 20 30 40 50 60 MDIIGRAKKE LAEYVAAQLG ISEEEVFKNI TYPPREELGD LSLALPSLIK GNINEKAKLL 70 80 90 100 110 120 QEYKGELIER IEVAGIYLNA RLNLRNIFVS IFSKLDDSYG LEKIEKPKRI VVEHTSANPI 130 140 150 160 170 180 HPLHIGHLRN TILGDALARA LKARGHSVNV RFYVNDTGRQ VAVLIYGLKL LGFPDPEPNV 190 200 210 220 230 240 KKDLWLGIIY AMTNVILEIR KLREELKKLS ESEYREKVRE LDELIVIAND LRNRNEVLFD 250 260 270 280 290 300 KLADAINAKE EPEKEIGEII KKYEEGNDEL KGIIRKYISY ALEGFSETLS KLNIRFDNFD 310 320 330 340 350 360 YESDLLWENM VNEVLKALLS SSAKIPYKGV IALDLDSFLG DEARSKLRIP KGLKIPPLVL 370 380 390 400 410 420 MRSDGTTLYT VRDIAYTIFK FNQFNADFVI NVIAEEQYIP QIQLRGALEL LGYSRFAENL 430 440 450 460 470 480 LHYSYGMVNI QGLRMSGRLG KIITIDEIYE KLDNIVRNKL KEKGGNMENI DDIANAALRY 490 500 510 520 530 540 AILSVSANKP LSFDLNRITS FEQNSGPYLQ YTYARAANIL AKSTENLSMD KVDFSDLVGD 550 560 570 580 590 600 KRNILILIAK FPEVFKNAVD NLRLEDLVAF LRELSDIFNS WYDKERVLQE QDPRKRMLRL 610 620 YIVKGVSVVL KNGLSVLGIR SLERM

References

[1]

"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006641 Genomic DNA. Translation: AAK41148.1.
PIR	E90236.
RefSeq	NP_342358.1. NC_002754.1.
3D structure databases
ProteinModelPortal	Q97ZN1.
ModBase	Search...
Protein-protein interaction databases
STRING	273057.SSO0857.
Proteomic databases
PRIDE	Q97ZN1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK41148; AAK41148; SSO0857.
GeneID	1455115.
KEGG	sso:SSO0857.
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HOG000247213.
KO	K01887.
OMA	CKSMLAW.
ProtClustDB	PRK01611.
Family and domain databases
Gene3D	3.30.1360.70. 1 hit. 3.40.50.620. 2 hits.
HAMAP	MF_00123. Arg_tRNA_synth.
InterPro	IPR001278. Arg-tRNA-ligase_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
PANTHER	PTHR11956. PTHR11956. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 2 hits. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_SULSO

Accession

Primary (citable) accession number: Q97ZN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 1, 2001
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program