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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Carbamoyl phosphateBy similarity1
Binding sitei105Carbamoyl phosphateBy similarity1
Binding sitei163OrnithineBy similarity1
Binding sitei227OrnithineBy similarity1
Binding sitei295Carbamoyl phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:SSO0871
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130771 – 307Ornithine carbamoyltransferaseAdd BLAST307

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0871.

Structurei

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei29Important for structural integrityBy similarity1
Sitei145Important for structural integrityBy similarity1

3D structure databases

ProteinModelPortaliQ97ZM1.
SMRiQ97ZM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 58Carbamoyl phosphate bindingBy similarity5
Regioni132 – 135Carbamoyl phosphate bindingBy similarity4
Regioni231 – 232Ornithine bindingBy similarity2
Regioni266 – 269Carbamoyl phosphate bindingBy similarity4

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiarCOG00912. Archaea.
COG0078. LUCA.
HOGENOMiHOG000022686.
InParanoidiQ97ZM1.
KOiK00611.
OMAiDGNNVCN.
OrthoDBiPOG093Z05BF.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
InterProiView protein in InterPro
IPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR036901. Asp/Orn_carbamoylTrfase_sf.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
PfamiView protein in Pfam
PF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
PROSITEiView protein in PROSITE
PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97ZM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRGKSLLCL LDFQTHEIEK MLEVSFLMKS YVYYNKVPNS LSGKRVALLF
60 70 80 90 100
EKPSTRTRVS TELAVSLLGG IPIVLNKQDL QWSRGELIED TGRVLGRVVN
110 120 130 140 150
GIGARVLNHL TLVKLKESSG VPVFNLLSDL SHPLQALADL MTIRERFGNN
160 170 180 190 200
LVKIAFVGDG SDNVLLSLMA IVAKLGLELH VATPKELKPR DDLYKIISEI
210 220 230 240 250
AEDTGSVIEF HEDPYEAVRG VHVVYTDVWV SMGQENIAEQ KKRMLQNYRV
260 270 280 290 300
TADLMKYAVK DAIFMHCLPA NRGEEVDPEV IDGSKSAVWD QAENRLYTTM

AVFSLFI
Length:307
Mass (Da):34,440
Last modified:October 1, 2001 - v1
Checksum:i4C55C2516DD7D15B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41159.1.
PIRiH90237.
RefSeqiWP_009992290.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41159; AAK41159; SSO0871.
GeneIDi27427197.
KEGGisso:SSO0871.
PATRICifig|273057.12.peg.880.

Similar proteinsi

Entry informationi

Entry nameiOTC_SULSO
AccessioniPrimary (citable) accession number: Q97ZM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome