argF

Functionⁱ

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityⁱ

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayⁱ: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Ornithine carbamoyltransferase (argF)
Argininosuccinate synthase (argG)
Argininosuccinate lyase (argH)

This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	81	Carbamoyl phosphateBy similarity	1
Binding siteⁱ	105	Carbamoyl phosphateBy similarity	1
Binding siteⁱ	163	OrnithineBy similarity	1
Binding siteⁱ	227	OrnithineBy similarity	1
Binding siteⁱ	295	Carbamoyl phosphateBy similarity	1

GO - Molecular functionⁱ

amino acid binding Source: InterPro
ornithine carbamoyltransferase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

arginine biosynthetic process via ornithine Source: GO_Central
urea cycle Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayⁱ	UPA00068; UER00112.

UniPathwayⁱ

UPA00068; UER00112.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ornithine carbamoyltransferase (EC:2.1.3.3) Short name: OTCase
Gene namesⁱ	Name:argF Ordered Locus Names:SSO0871
Organismⁱ	Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifierⁱ	273057 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › TACK group › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus › Sulfolobus solfataricus
Proteomesⁱ	UP000001974 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm By similarity

GO - Cellular componentⁱ

cytoplasm Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000113077	1 – 307	Ornithine carbamoyltransferaseAdd BLAST		307

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	273057.SSO0871.

STRINGⁱ

273057.SSO0871.

Structureⁱ

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	29	Important for structural integrityBy similarity		1
Siteⁱ	145	Important for structural integrityBy similarity		1

3D structure databases

ProteinModelPortalⁱ	Q97ZM1.
SMRⁱ	Q97ZM1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	54 – 58	Carbamoyl phosphate bindingBy similarity	5
Regionⁱ	132 – 135	Carbamoyl phosphate bindingBy similarity	4
Regionⁱ	231 – 232	Ornithine bindingBy similarity	2
Regionⁱ	266 – 269	Carbamoyl phosphate bindingBy similarity	4

Sequence similaritiesⁱ

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGⁱ	arCOG00912. Archaea. COG0078. LUCA.
HOGENOMⁱ	HOG000022686.
InParanoidⁱ	Q97ZM1.
KEGG Orthology (KO) More...KOⁱ	K00611.
OMAⁱ	DGNNVCN.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z05BF.

Family and domain databases

Gene3Dⁱ	3.40.50.1370. 2 hits.
InterProⁱ	View protein in InterPro IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR036901. Asp/Orn_carbamoylTrfase_sf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit.
PRINTSⁱ	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAMⁱ	SSF53671. SSF53671. 1 hit.
TIGRFAMsⁱ	TIGR00658. orni_carb_tr. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00097. CARBAMOYLTRANSFERASE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q97ZM1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFRGKSLLCL LDFQTHEIEK MLEVSFLMKS YVYYNKVPNS LSGKRVALLF 
        60         70         80         90        100
EKPSTRTRVS TELAVSLLGG IPIVLNKQDL QWSRGELIED TGRVLGRVVN 
       110        120        130        140        150
GIGARVLNHL TLVKLKESSG VPVFNLLSDL SHPLQALADL MTIRERFGNN 
       160        170        180        190        200
LVKIAFVGDG SDNVLLSLMA IVAKLGLELH VATPKELKPR DDLYKIISEI 
       210        220        230        240        250
AEDTGSVIEF HEDPYEAVRG VHVVYTDVWV SMGQENIAEQ KKRMLQNYRV 
       260        270        280        290        300
TADLMKYAVK DAIFMHCLPA NRGEEVDPEV IDGSKSAVWD QAENRLYTTM 

AVFSLFI

Length:307

Mass (Da):34,440

Last modified:October 1, 2001 - v1

Checksum:ⁱ4C55C2516DD7D15B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE006641 Genomic DNA. Translation: AAK41159.1.
PIRⁱ	H90237.
NCBI Reference Sequences More...RefSeqⁱ	WP_009992290.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAK41159; AAK41159; SSO0871.
GeneIDⁱ	27427197.
KEGGⁱ	sso:SSO0871.
PATRICⁱ	fig\|273057.12.peg.880.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q97ZM1	A0A0E3MGK7 D0KTK1	Sulfolobus solfataricus Sulfolobus solfataricus (strain 98/2)	307	UniRef100_Q97ZM1	Cluster: Ornithine carbamoyltransferase	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q97ZM1	A0A0E3MGK7 D0KTK1 C3MVA4 M9U958 C3N5K3 C3MPX7 F0NEZ5 C3NE67 C4KH68 C3NHJ6 +2	Sulfolobus solfataricus Sulfolobus solfataricus (strain 98/2) Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) Sulfolobus islandicus LAL14/1 Sulfolobus islandicus (strain M.16.27) Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) Sulfolobus islandicus (strain REY15A) Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) And more	307	UniRef90_Q97ZM1	Cluster: Ornithine carbamoyltransferase	13

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q97ZM1	A0A0E3MGK7 D0KTK1 F0NKA2 C3NHJ6 D2PK21 C3MVA4 M9U958 C3N5K3 C3MPX7 F0NEZ5 +6	Sulfolobus solfataricus Sulfolobus solfataricus (strain 98/2) Sulfolobus islandicus (strain HVE10/4) Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) Sulfolobus islandicus (strain L.D.8.5 / Lassen #2) Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) Sulfolobus islandicus LAL14/1 Sulfolobus islandicus (strain M.16.27) Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) Sulfolobus islandicus (strain REY15A) And more	307	UniRef50_Q97ZM1	Cluster: Ornithine carbamoyltransferase	17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE006641 Genomic DNA. Translation: AAK41159.1.
PIRⁱ	H90237.
NCBI Reference Sequences More...RefSeqⁱ	WP_009992290.1. NC_002754.1.

3D structure databases

ProteinModelPortalⁱ	Q97ZM1.
SMRⁱ	Q97ZM1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	273057.SSO0871.

STRINGⁱ

273057.SSO0871.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAK41159; AAK41159; SSO0871.
GeneIDⁱ	27427197.
KEGGⁱ	sso:SSO0871.
PATRICⁱ	fig\|273057.12.peg.880.

Phylogenomic databases

eggNOGⁱ	arCOG00912. Archaea. COG0078. LUCA.
HOGENOMⁱ	HOG000022686.
InParanoidⁱ	Q97ZM1.
KEGG Orthology (KO) More...KOⁱ	K00611.
OMAⁱ	DGNNVCN.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z05BF.

Enzyme and pathway databases

UniPathwayⁱ	UPA00068; UER00112.

UniPathwayⁱ

UPA00068; UER00112.

Family and domain databases

Gene3Dⁱ	3.40.50.1370. 2 hits.
InterProⁱ	View protein in InterPro IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR036901. Asp/Orn_carbamoylTrfase_sf. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit.
PRINTSⁱ	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAMⁱ	SSF53671. SSF53671. 1 hit.
TIGRFAMsⁱ	TIGR00658. orni_carb_tr. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00097. CARBAMOYLTRANSFERASE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	OTC_SULSO
Accessionⁱ	Q97ZM1Primary (citable) accession number: Q97ZM1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
	Last sequence update:	October 1, 2001
	Last modified:	March 28, 2018
	This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q97ZM1 (OTC_SULSO)

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Ornithine carbamoyltransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-arginine biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Sites

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: L-arginine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ