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Protein

Acylphosphatase

Gene

acyP

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Kineticsi

  1. KM=0.36 mM for benzoylphosphate at 25 degrees Celsius1 Publication

    pH dependencei

    Optimum pH is 4.7-5.7.1 Publication

    Temperature dependencei

    Optimum temperature is 81 degrees Celsius. Thermostable up to 100.8 degrees Celsius. Poorly active at 25 degrees Celsius. Enzymatic activity is increased 4-fold by temperature increase from 25 to 45 degrees Celsius and more than 9-fold at 98 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei30 – 3011 Publication
    Active sitei48 – 4811 Publication

    GO - Molecular functioni

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-844-MONOMER.
    BRENDAi3.6.1.7. 6163.
    SABIO-RKQ97ZL0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acylphosphatase (EC:3.6.1.7)
    Alternative name(s):
    Acylphosphate phosphohydrolase
    Gene namesi
    Name:acyP
    Ordered Locus Names:SSO0887
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    Proteomesi
    • UP000001974 Componenti: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 101101AcylphosphatasePRO_0000326870Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273057.SSO0887.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 113Combined sources
    Beta strandi13 – 2311Combined sources
    Beta strandi25 – 284Combined sources
    Helixi29 – 3911Combined sources
    Beta strandi43 – 486Combined sources
    Beta strandi50 – 523Combined sources
    Beta strandi54 – 618Combined sources
    Helixi62 – 7211Combined sources
    Beta strandi80 – 9011Combined sources
    Beta strandi96 – 1016Combined sources

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Y9ONMR-A1-101[»]
    2BJDX-ray1.27A/B1-101[»]
    2BJEX-ray1.90A/C/E/G1-101[»]
    4OIXX-ray1.55A1-101[»]
    4OJ1X-ray1.70A/B1-101[»]
    4OJ3X-ray2.20A/B1-101[»]
    4OJGX-ray1.38A/B1-101[»]
    4OJHX-ray1.60A/B1-101[»]
    DisProtiDP00513.
    ProteinModelPortaliQ97ZL0.
    SMRiQ97ZL0. Positions 1-101.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ97ZL0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 10187Acylphosphatase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the acylphosphatase family.Curated
    Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiarCOG01674. Archaea.
    COG1254. LUCA.
    HOGENOMiHOG000292686.
    InParanoidiQ97ZL0.
    KOiK01512.
    OMAiIEQEYAD.

    Family and domain databases

    InterProiIPR001792. Acylphosphatase-like_dom.
    IPR017968. Acylphosphatase_CS.
    [Graphical view]
    PfamiPF00708. Acylphosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF54975. SSF54975. 1 hit.
    PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
    PS00151. ACYLPHOSPHATASE_2. 1 hit.
    PS51160. ACYLPHOSPHATASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q97ZL0-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MKKWSDTEVF EMLKRMYARV YGLVQGVGFR KFVQIHAIRL GIKGYAKNLP
    60 70 80 90 100
    DGSVEVVAEG YEEALSKLLE RIKQGPPAAE VEKVDYSFSE YKGEFEDFET

    Y
    Length:101
    Mass (Da):11,636
    Last modified:October 1, 2001 - v1
    Checksum:i9BC4BF537EA7B4FA
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AE006641 Genomic DNA. Translation: AAK41170.1.
    PIRiC90239.

    Genome annotation databases

    EnsemblBacteriaiAAK41170; AAK41170; SSO0887.
    KEGGisso:SSO0887.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AE006641 Genomic DNA. Translation: AAK41170.1.
    PIRiC90239.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Y9ONMR-A1-101[»]
    2BJDX-ray1.27A/B1-101[»]
    2BJEX-ray1.90A/C/E/G1-101[»]
    4OIXX-ray1.55A1-101[»]
    4OJ1X-ray1.70A/B1-101[»]
    4OJ3X-ray2.20A/B1-101[»]
    4OJGX-ray1.38A/B1-101[»]
    4OJHX-ray1.60A/B1-101[»]
    DisProtiDP00513.
    ProteinModelPortaliQ97ZL0.
    SMRiQ97ZL0. Positions 1-101.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi273057.SSO0887.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAAK41170; AAK41170; SSO0887.
    KEGGisso:SSO0887.

    Phylogenomic databases

    eggNOGiarCOG01674. Archaea.
    COG1254. LUCA.
    HOGENOMiHOG000292686.
    InParanoidiQ97ZL0.
    KOiK01512.
    OMAiIEQEYAD.

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-844-MONOMER.
    BRENDAi3.6.1.7. 6163.
    SABIO-RKQ97ZL0.

    Miscellaneous databases

    EvolutionaryTraceiQ97ZL0.

    Family and domain databases

    InterProiIPR001792. Acylphosphatase-like_dom.
    IPR017968. Acylphosphatase_CS.
    [Graphical view]
    PfamiPF00708. Acylphosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF54975. SSF54975. 1 hit.
    PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
    PS00151. ACYLPHOSPHATASE_2. 1 hit.
    PS51160. ACYLPHOSPHATASE_3. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiACYP_SULSO
    AccessioniPrimary (citable) accession number: Q97ZL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: October 1, 2001
    Last modified: February 17, 2016
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.