Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BRENDAi3.2.2.B5 6163
4.2.99.18 6163

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:SSO0904
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595661 – 207Probable N-glycosylase/DNA lyaseAdd BLAST207

Proteomic databases

PRIDEiQ97ZK2

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0904

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 7Combined sources5
Helixi9 – 26Combined sources18
Helixi30 – 43Combined sources14
Helixi48 – 58Combined sources11
Helixi59 – 63Combined sources5
Helixi67 – 76Combined sources10
Helixi82 – 96Combined sources15
Turni97 – 99Combined sources3
Helixi100 – 110Combined sources11
Helixi112 – 119Combined sources8
Helixi127 – 136Combined sources10
Helixi147 – 155Combined sources9
Helixi169 – 185Combined sources17
Helixi190 – 202Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FHGX-ray1.90A1-207[»]
ProteinModelPortaliQ97ZK2
SMRiQ97ZK2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97ZK2

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04357 Archaea
COG1059 LUCA
HOGENOMiHOG000224507
InParanoidiQ97ZK2
KOiK03653
OMAiGYKEASH
OrthoDBiPOG093Z0AOL

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
HAMAPiMF_00241 Ogg, 1 hit
InterProiView protein in InterPro
IPR012092 DNA_glyclase/DNA_lyase_thermo
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
PfamiView protein in Pfam
PF00730 HhH-GPD, 1 hit
PIRSFiPIRSF005954 Thrmst_ogg, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit

Sequencei

Sequence statusi: Complete.

Q97ZK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSLVQNPK VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS
60 70 80 90 100
AYQALNCLGQ KIYYANEEEI RNILKSCKYR FYNLKAKYII MAREKVYGRL
110 120 130 140 150
KEEIKPLADE DQQLARERLL NIKGIGMKEA SHFLRNVGYF DLAIIDRHII
160 170 180 190 200
DFMRRIGAIG ETNVKQLSKS LYISFENILK SIASNLNMSV GILDLFIWYK

ETNTIVK
Length:207
Mass (Da):24,253
Last modified:October 1, 2001 - v1
Checksum:i823B754303F3F950
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK41186.1
PIRiC90241
RefSeqiWP_009992328.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK41186; AAK41186; SSO0904
GeneIDi27427224
KEGGisso:SSO0904
PATRICifig|273057.12.peg.906

Entry informationi

Entry nameiOGG1_SULSO
AccessioniPrimary (citable) accession number: Q97ZK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health