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Q97ZK2 (OGG1_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

  1. 8-oxoguanine DNA glycosylase
    EC=3.2.2.-
  2. DNA-(apurinic or apyrimidinic site) lyase
    Short name=AP lyase
    EC=4.2.99.18
Gene names
Name:ogg
Ordered Locus Names:SSO0904
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus ›

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241

Sequence similarities

Belongs to the type-2 OGG1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241
PRO_0000159566

Sites

Active site1281 By similarity

Secondary structure

1 .......................... 207
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q97ZK2 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 823B754303F3F950

FASTA20724,253
        10         20         30         40         50         60 
MLRSLVQNPK VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS AYQALNCLGQ 

        70         80         90        100        110        120 
KIYYANEEEI RNILKSCKYR FYNLKAKYII MAREKVYGRL KEEIKPLADE DQQLARERLL 

       130        140        150        160        170        180 
NIKGIGMKEA SHFLRNVGYF DLAIIDRHII DFMRRIGAIG ETNVKQLSKS LYISFENILK 

       190        200 
SIASNLNMSV GILDLFIWYK ETNTIVK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE006641 Genomic DNA. Translation: AAK41186.1.
PIRC90241.
RefSeqNP_342396.1. NC_002754.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3FHGX-ray1.90A1-207[»]
ProteinModelPortalQ97ZK2.
ModBaseSearch...

Protein-protein interaction databases

STRING273057.SSO0904.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK41186; AAK41186; SSO0904.
GeneID1455153.
KEGGsso:SSO0904.

Phylogenomic databases

eggNOGCOG1059.
HOGENOMHOG000224507.
KOK03653.
OMAIIDRHIL.
ProtClustDBPRK01229.

Family and domain databases

Gene3D1.10.340.30. 1 hit.
HAMAPMF_00241. Ogg.
InterProIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFPIRSF005954. Thrmst_ogg. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMSSF48150. DNA_glycsylse. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ97ZK2.

Entry information

Entry nameOGG1_SULSO
AccessionPrimary (citable) accession number: Q97ZK2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2001
Last modified: May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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