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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BRENDAi3.2.2.B5. 6163.
4.2.99.18. 6163.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:SSO0904
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595661 – 207Probable N-glycosylase/DNA lyaseAdd BLAST207

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO0904.

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 7Combined sources5
Helixi9 – 26Combined sources18
Helixi30 – 43Combined sources14
Helixi48 – 58Combined sources11
Helixi59 – 63Combined sources5
Helixi67 – 76Combined sources10
Helixi82 – 96Combined sources15
Turni97 – 99Combined sources3
Helixi100 – 110Combined sources11
Helixi112 – 119Combined sources8
Helixi127 – 136Combined sources10
Helixi147 – 155Combined sources9
Helixi169 – 185Combined sources17
Helixi190 – 202Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FHGX-ray1.90A1-207[»]
ProteinModelPortaliQ97ZK2.
SMRiQ97ZK2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97ZK2.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04357. Archaea.
COG1059. LUCA.
HOGENOMiHOG000224507.
InParanoidiQ97ZK2.
KOiK03653.
OMAiELCFCIL.

Family and domain databases

CDDicd00056. ENDO3c. 1 hit.
Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg. 1 hit.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97ZK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSLVQNPK VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS
60 70 80 90 100
AYQALNCLGQ KIYYANEEEI RNILKSCKYR FYNLKAKYII MAREKVYGRL
110 120 130 140 150
KEEIKPLADE DQQLARERLL NIKGIGMKEA SHFLRNVGYF DLAIIDRHII
160 170 180 190 200
DFMRRIGAIG ETNVKQLSKS LYISFENILK SIASNLNMSV GILDLFIWYK

ETNTIVK
Length:207
Mass (Da):24,253
Last modified:October 1, 2001 - v1
Checksum:i823B754303F3F950
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41186.1.
PIRiC90241.
RefSeqiWP_009992328.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41186; AAK41186; SSO0904.
GeneIDi27427224.
KEGGisso:SSO0904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41186.1.
PIRiC90241.
RefSeqiWP_009992328.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FHGX-ray1.90A1-207[»]
ProteinModelPortaliQ97ZK2.
SMRiQ97ZK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41186; AAK41186; SSO0904.
GeneIDi27427224.
KEGGisso:SSO0904.

Phylogenomic databases

eggNOGiarCOG04357. Archaea.
COG1059. LUCA.
HOGENOMiHOG000224507.
InParanoidiQ97ZK2.
KOiK03653.
OMAiELCFCIL.

Enzyme and pathway databases

BRENDAi3.2.2.B5. 6163.
4.2.99.18. 6163.

Miscellaneous databases

EvolutionaryTraceiQ97ZK2.

Family and domain databases

CDDicd00056. ENDO3c. 1 hit.
Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg. 1 hit.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOGG1_SULSO
AccessioniPrimary (citable) accession number: Q97ZK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.