Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q97ZI9 (GCSPB_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:SSO0917
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_0000167031

Amino acid modifications

Modified residue2771N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97ZI9 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 65F18BCD42AB3185

FASTA50856,742
        10         20         30         40         50         60 
MWRQAKWNEP LIFELNKSGA ARQGFLINKD EEIRSQIKEM KIPKNLLREN EPDLPSLSEL 

        70         80         90        100        110        120 
EVVRHFVRLS QMNFGVDIGI MPLGSCTMKY NPKIEEKATA ITEFHHPLED EDYIQGILEM 

       130        140        150        160        170        180 
IYELQNWFSE ITGMDECSLQ VPAGSAGEFA GVLMIKKYHE EHNRNYKDTI LVADTAHGTN 

       190        200        210        220        230        240 
PASAAMAGYK VMYVKSNAEG LVDMDILREI VNDKTAGFML TNPNTLGLFE ENILEISKII 

       250        260        270        280        290        300 
HSTNAVLYYD GANLNGVLGI ARPGDMGFDI VHLNLHKTFA VPHGGGGPGA GAICAKGELV 

       310        320        330        340        350        360 
NYLPYPMVEK VNGKYKLSKI PKNSIGKIAT FYGNVGNLAR SFAYILGLGP QGIQMIGKMS 

       370        380        390        400        410        420 
TLATNYLIAK LRDVKELELI APNRHRKHEV VFSVKQLMEN YGVSANDVAK ALLDNGFYAP 

       430        440        450        460        470        480 
TIYFPPIVEE ALMIEPTETE TKETLDMFAE TLKKIVNDAK INPEQVMKSP NNTSIARLDQ 

       490        500 
AYANHPSTIT PTYRVLRLRR LGKIDYLK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK41199.1.
PIRH90242.
RefSeqNP_342409.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ97ZI9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0917.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK41199; AAK41199; SSO0917.
GeneID1455166.
KEGGsso:SSO0917.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
OMAMHINLHK.
ProtClustDBPRK04366.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-874-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_SULSO
AccessionPrimary (citable) accession number: Q97ZI9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families