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Q97ZI8

- GCSPA_SULSO

UniProt

Q97ZI8 - GCSPA_SULSO

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:SSO0918
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_0000166989Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi273057.SSO0918.

Structurei

3D structure databases

ProteinModelPortaliQ97ZI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
InParanoidiQ97ZI8.
KOiK00282.
OMAiGLEVANC.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97ZI8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKHPWLPNL DLTDEMLKEI GVNSLDDLFN DIPAEIKINR LLKVAKDKPL
60 70 80 90 100
SEYEIEKEIY EKVKKNVELE APPFIGAGIC PHYIPNAVKF IIGRSEFYTS
110 120 130 140 150
YTPYQPEISQ GILQALFEYQ SLMAELLEMD VVNASMYDWG SALAEAVLMA
160 170 180 190 200
NRINGKKTVL VPENANPFHK EVMRTWIQGK GIKIEEVKYD KNSGEVDIED
210 220 230 240 250
LEKKSSSNDV SAIYVQQPNF FGIFESNIEH IIDVAKHKKA LSIIGVNPLS
260 270 280 290 300
LGLIKPPGSY EADIVVGDGQ ELGLPLNFGG PLMGIFAVRW DMGLVRQMPG
310 320 330 340 350
RIVGITRDVN NNMGFTLILQ TREQFIKREK ATSNITTNEA LLALANAVYL
360 370 380 390 400
SLLGKEGIRE LAEEIYFRSH YAAKRLTEID NVIMPFTSDF FEEFVIKFPI
410 420 430 440 450
EYNIINDKLK ERKLQGGLKL SIHTSLFCVT EVHDKKSIDL LVSTIQEAIK

SVETS
Length:455
Mass (Da):51,367
Last modified:October 1, 2001 - v1
Checksum:i510B48D12A705EAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41200.1.
PIRiA99243.
RefSeqiNP_342410.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41200; AAK41200; SSO0918.
GeneIDi1455167.
KEGGisso:SSO0918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41200.1 .
PIRi A99243.
RefSeqi NP_342410.1. NC_002754.1.

3D structure databases

ProteinModelPortali Q97ZI8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO0918.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK41200 ; AAK41200 ; SSO0918 .
GeneIDi 1455167.
KEGGi sso:SSO0918.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
InParanoidi Q97ZI8.
KOi K00282.
OMAi GLEVANC.

Enzyme and pathway databases

BioCyci SSOL273057:GCH2-875-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiGCSPA_SULSO
AccessioniPrimary (citable) accession number: Q97ZI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3