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Q97ZI8 (GCSPA_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:SSO0918
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_0000166989

Sequences

Sequence LengthMass (Da)Tools
Q97ZI8 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 510B48D12A705EAA

FASTA45551,367
        10         20         30         40         50         60 
MYKHPWLPNL DLTDEMLKEI GVNSLDDLFN DIPAEIKINR LLKVAKDKPL SEYEIEKEIY 

        70         80         90        100        110        120 
EKVKKNVELE APPFIGAGIC PHYIPNAVKF IIGRSEFYTS YTPYQPEISQ GILQALFEYQ 

       130        140        150        160        170        180 
SLMAELLEMD VVNASMYDWG SALAEAVLMA NRINGKKTVL VPENANPFHK EVMRTWIQGK 

       190        200        210        220        230        240 
GIKIEEVKYD KNSGEVDIED LEKKSSSNDV SAIYVQQPNF FGIFESNIEH IIDVAKHKKA 

       250        260        270        280        290        300 
LSIIGVNPLS LGLIKPPGSY EADIVVGDGQ ELGLPLNFGG PLMGIFAVRW DMGLVRQMPG 

       310        320        330        340        350        360 
RIVGITRDVN NNMGFTLILQ TREQFIKREK ATSNITTNEA LLALANAVYL SLLGKEGIRE 

       370        380        390        400        410        420 
LAEEIYFRSH YAAKRLTEID NVIMPFTSDF FEEFVIKFPI EYNIINDKLK ERKLQGGLKL 

       430        440        450 
SIHTSLFCVT EVHDKKSIDL LVSTIQEAIK SVETS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK41200.1.
PIRA99243.
RefSeqNP_342410.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ97ZI8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO0918.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK41200; AAK41200; SSO0918.
GeneID1455167.
KEGGsso:SSO0918.

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-875-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_SULSO
AccessionPrimary (citable) accession number: Q97ZI8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families