Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal recognition particle 54 kDa protein

Gene

srp54

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi103 – 1108GTPUniRule annotation
Nucleotide bindingi185 – 1895GTPUniRule annotation
Nucleotide bindingi245 – 2484GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

GTP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-924-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle 54 kDa proteinUniRule annotation
Short name:
SRP54UniRule annotation
Gene namesi
Name:srp54UniRule annotation
Ordered Locus Names:SSO0971
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Signal recognition particle 54 kDa proteinPRO_0000101187Add
BLAST

Interactioni

Subunit structurei

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.UniRule annotation

Protein-protein interaction databases

STRINGi273057.SSO0971.

Structurei

Secondary structure

1
447
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 128Combined sources
Turni13 – 153Combined sources
Helixi19 – 3618Combined sources
Helixi41 – 5717Combined sources
Helixi66 – 8217Combined sources
Beta strandi84 – 863Combined sources
Beta strandi94 – 1018Combined sources
Helixi109 – 12214Combined sources
Beta strandi127 – 1326Combined sources
Helixi137 – 14812Combined sources
Turni149 – 1513Combined sources
Helixi163 – 17311Combined sources
Turni174 – 1785Combined sources
Beta strandi180 – 1867Combined sources
Beta strandi190 – 1923Combined sources
Helixi197 – 20913Combined sources
Beta strandi212 – 2198Combined sources
Helixi220 – 2267Combined sources
Helixi227 – 23610Combined sources
Beta strandi238 – 2458Combined sources
Helixi247 – 2493Combined sources
Helixi253 – 26311Combined sources
Beta strandi266 – 2716Combined sources
Beta strandi274 – 2774Combined sources
Beta strandi279 – 2813Combined sources
Helixi284 – 2929Combined sources
Helixi296 – 30611Combined sources
Helixi329 – 34113Combined sources
Beta strandi344 – 3463Combined sources
Helixi347 – 3504Combined sources
Turni351 – 3533Combined sources
Helixi363 – 3686Combined sources
Helixi377 – 3826Combined sources
Turni388 – 3903Combined sources
Helixi392 – 3943Combined sources
Helixi397 – 40711Combined sources
Helixi411 – 42919Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QZWX-ray4.10A/C/E/G1-432[»]
1QZXX-ray4.00A/B1-432[»]
2IY3electron microscopy16.00A297-432[»]
3KL4X-ray3.50A2-432[»]
3ZN8electron microscopy12.00M308-431[»]
ProteinModelPortaliQ97ZE7.
SMRiQ97ZE7. Positions 1-432.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97ZE7.

Family & Domainsi

Domaini

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.UniRule annotation

Sequence similaritiesi

Belongs to the GTP-binding SRP family. SRP54 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01228. Archaea.
COG0541. LUCA.
HOGENOMiHOG000036165.
InParanoidiQ97ZE7.
KOiK03106.
OMAiMLPGMGQ.

Family and domain databases

Gene3Di1.10.260.30. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00306. SRP54.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004125. Signal_recog_particle_SRP54_M.
IPR022941. SRP54.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
PF02978. SRP_SPB. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF47446. SSF47446. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97ZE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENIRDAVR KFLTGSTPYE KAVDEFIKDL QKSLISSDVN VKLVFSLTAK
60 70 80 90 100
IKERLNKEKP PSVLERKEWF ISIVYDELSK LFGGDKEPNV NPTKLPFIIM
110 120 130 140 150
LVGVQGSGKT TTAGKLAYFY KKRGYKVGLV AADVYRPAAY DQLLQLGNQI
160 170 180 190 200
GVQVYGEPNN QNPIEIAKKG VDIFVKNKMD IIIVDTAGRH GYGEETKLLE
210 220 230 240 250
EMKEMYDVLK PDDVILVIDA SIGQKAYDLA SRFHQASPIG SVIITKMDGT
260 270 280 290 300
AKGGGALSAV VATGATIKFI GTGEKIDELE TFNAKRFVSR ILGMGDIESI
310 320 330 340 350
LEKVKGLEEY DKIQKKMEDV MEGKGKLTLR DVYAQIIALR KMGPLSKVLQ
360 370 380 390 400
HIPGLGIMLP TPSEDQLKIG EEKIRRWLAA LNSMTYKELE NPNIIDKSRM
410 420 430 440
RRIAEGSGLE VEEVRELLEW YNNMNRLLKM VKRRRGNIDK LFGGKIG
Length:447
Mass (Da):50,047
Last modified:October 1, 2001 - v1
Checksum:i2A21A42E9E4ED9E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41245.1.
PIRiF90248.
RefSeqiWP_010923154.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41245; AAK41245; SSO0971.
GeneIDi27427290.
KEGGisso:SSO0971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41245.1.
PIRiF90248.
RefSeqiWP_010923154.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QZWX-ray4.10A/C/E/G1-432[»]
1QZXX-ray4.00A/B1-432[»]
2IY3electron microscopy16.00A297-432[»]
3KL4X-ray3.50A2-432[»]
3ZN8electron microscopy12.00M308-431[»]
ProteinModelPortaliQ97ZE7.
SMRiQ97ZE7. Positions 1-432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41245; AAK41245; SSO0971.
GeneIDi27427290.
KEGGisso:SSO0971.

Phylogenomic databases

eggNOGiarCOG01228. Archaea.
COG0541. LUCA.
HOGENOMiHOG000036165.
InParanoidiQ97ZE7.
KOiK03106.
OMAiMLPGMGQ.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-924-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ97ZE7.

Family and domain databases

Gene3Di1.10.260.30. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00306. SRP54.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004125. Signal_recog_particle_SRP54_M.
IPR022941. SRP54.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
PF02978. SRP_SPB. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF47446. SSF47446. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiSRP54_SULSO
AccessioniPrimary (citable) accession number: Q97ZE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2001
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.