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Protein

Signal recognition particle 54 kDa protein

Gene

srp54

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi103 – 110GTPUniRule annotation8
Nucleotide bindingi185 – 189GTPUniRule annotation5
Nucleotide bindingi245 – 248GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

GTP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle 54 kDa proteinUniRule annotation
Short name:
SRP54UniRule annotation
Gene namesi
Name:srp54UniRule annotation
Ordered Locus Names:SSO0971
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: The SRP-RNC complex is targeted to the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001011871 – 447Signal recognition particle 54 kDa proteinAdd BLAST447

Interactioni

Subunit structurei

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.UniRule annotation

Protein-protein interaction databases

STRINGi273057.SSO0971.

Structurei

Secondary structure

1447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 13Combined sources9
Helixi18 – 36Combined sources19
Helixi41 – 57Combined sources17
Helixi67 – 80Combined sources14
Beta strandi84 – 86Combined sources3
Beta strandi93 – 102Combined sources10
Helixi109 – 122Combined sources14
Beta strandi127 – 131Combined sources5
Helixi139 – 150Combined sources12
Beta strandi153 – 156Combined sources4
Helixi163 – 176Combined sources14
Beta strandi180 – 185Combined sources6
Beta strandi190 – 192Combined sources3
Helixi193 – 195Combined sources3
Helixi196 – 209Combined sources14
Beta strandi212 – 219Combined sources8
Helixi226 – 236Combined sources11
Beta strandi241 – 245Combined sources5
Helixi247 – 249Combined sources3
Helixi254 – 263Combined sources10
Beta strandi266 – 271Combined sources6
Beta strandi273 – 275Combined sources3
Beta strandi279 – 281Combined sources3
Helixi284 – 291Combined sources8
Helixi296 – 306Combined sources11
Helixi329 – 341Combined sources13
Beta strandi344 – 346Combined sources3
Helixi347 – 350Combined sources4
Turni351 – 353Combined sources3
Helixi363 – 368Combined sources6
Helixi377 – 382Combined sources6
Turni388 – 390Combined sources3
Helixi392 – 394Combined sources3
Helixi397 – 407Combined sources11
Helixi411 – 429Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QZWX-ray4.10A/C/E/G1-432[»]
1QZXX-ray4.00A/B1-432[»]
2IY3electron microscopy16.00A297-432[»]
3KL4X-ray3.50A2-432[»]
3ZN8electron microscopy12.00M308-431[»]
5L3SX-ray1.90A/C/E/G1-292[»]
5L3VX-ray2.30A/B1-293[»]
ProteinModelPortaliQ97ZE7.
SMRiQ97ZE7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97ZE7.

Family & Domainsi

Domaini

Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.UniRule annotation

Sequence similaritiesi

Belongs to the GTP-binding SRP family. SRP54 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01228. Archaea.
COG0541. LUCA.
HOGENOMiHOG000036165.
InParanoidiQ97ZE7.
KOiK03106.
OMAiMLPGMGQ.

Family and domain databases

Gene3Di1.10.260.30. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00306. SRP54. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004125. Signal_recog_particle_SRP54_M.
IPR022941. SRP54.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
PF02978. SRP_SPB. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF47446. SSF47446. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97ZE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENIRDAVR KFLTGSTPYE KAVDEFIKDL QKSLISSDVN VKLVFSLTAK
60 70 80 90 100
IKERLNKEKP PSVLERKEWF ISIVYDELSK LFGGDKEPNV NPTKLPFIIM
110 120 130 140 150
LVGVQGSGKT TTAGKLAYFY KKRGYKVGLV AADVYRPAAY DQLLQLGNQI
160 170 180 190 200
GVQVYGEPNN QNPIEIAKKG VDIFVKNKMD IIIVDTAGRH GYGEETKLLE
210 220 230 240 250
EMKEMYDVLK PDDVILVIDA SIGQKAYDLA SRFHQASPIG SVIITKMDGT
260 270 280 290 300
AKGGGALSAV VATGATIKFI GTGEKIDELE TFNAKRFVSR ILGMGDIESI
310 320 330 340 350
LEKVKGLEEY DKIQKKMEDV MEGKGKLTLR DVYAQIIALR KMGPLSKVLQ
360 370 380 390 400
HIPGLGIMLP TPSEDQLKIG EEKIRRWLAA LNSMTYKELE NPNIIDKSRM
410 420 430 440
RRIAEGSGLE VEEVRELLEW YNNMNRLLKM VKRRRGNIDK LFGGKIG
Length:447
Mass (Da):50,047
Last modified:October 1, 2001 - v1
Checksum:i2A21A42E9E4ED9E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41245.1.
PIRiF90248.
RefSeqiWP_010923154.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41245; AAK41245; SSO0971.
GeneIDi27427290.
KEGGisso:SSO0971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41245.1.
PIRiF90248.
RefSeqiWP_010923154.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QZWX-ray4.10A/C/E/G1-432[»]
1QZXX-ray4.00A/B1-432[»]
2IY3electron microscopy16.00A297-432[»]
3KL4X-ray3.50A2-432[»]
3ZN8electron microscopy12.00M308-431[»]
5L3SX-ray1.90A/C/E/G1-292[»]
5L3VX-ray2.30A/B1-293[»]
ProteinModelPortaliQ97ZE7.
SMRiQ97ZE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO0971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41245; AAK41245; SSO0971.
GeneIDi27427290.
KEGGisso:SSO0971.

Phylogenomic databases

eggNOGiarCOG01228. Archaea.
COG0541. LUCA.
HOGENOMiHOG000036165.
InParanoidiQ97ZE7.
KOiK03106.
OMAiMLPGMGQ.

Miscellaneous databases

EvolutionaryTraceiQ97ZE7.

Family and domain databases

Gene3Di1.10.260.30. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00306. SRP54. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004125. Signal_recog_particle_SRP54_M.
IPR022941. SRP54.
IPR000897. SRP54_GTPase_dom.
[Graphical view]
PfamiPF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
PF02978. SRP_SPB. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
[Graphical view]
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF47446. SSF47446. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSRP54_SULSO
AccessioniPrimary (citable) accession number: Q97ZE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.