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Protein

Translation initiation factor 2 subunit alpha

Gene

eif2a

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-997-MONOMER.
BRENDAi3.6.5.3. 6163.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit alphaUniRule annotation
Alternative name(s):
aIF2-alphaUniRule annotation
eIF-2-alphaUniRule annotation
Gene namesi
Name:eif2aUniRule annotation
Synonyms:aif2a
Ordered Locus Names:SSO1050
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Translation initiation factor 2 subunit alphaPRO_0000137402Add
BLAST

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Protein-protein interaction databases

DIPiDIP-29030N.
STRINGi273057.SSO1050.

Structurei

Secondary structure

1
266
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84Combined sources
Beta strandi14 – 218Combined sources
Beta strandi24 – 318Combined sources
Turni32 – 354Combined sources
Beta strandi37 – 415Combined sources
Helixi43 – 453Combined sources
Helixi54 – 574Combined sources
Beta strandi63 – 686Combined sources
Beta strandi73 – 753Combined sources
Beta strandi79 – 824Combined sources
Helixi89 – 11325Combined sources
Helixi118 – 1247Combined sources
Helixi126 – 1305Combined sources
Helixi136 – 14611Combined sources
Helixi149 – 1524Combined sources
Turni153 – 1553Combined sources
Helixi161 – 17414Combined sources
Beta strandi177 – 18711Combined sources
Turni190 – 1923Combined sources
Helixi193 – 20412Combined sources
Helixi207 – 2104Combined sources
Beta strandi214 – 22310Combined sources
Beta strandi226 – 2349Combined sources
Helixi236 – 25621Combined sources
Beta strandi259 – 2635Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AHOX-ray3.00B1-266[»]
2QMUX-ray3.20B175-266[»]
2QN6X-ray2.15B175-265[»]
3CW2X-ray2.80C/D/G/H1-266[»]
3QSYX-ray3.20B176-264[»]
3V11X-ray5.00B1-266[»]
ProteinModelPortaliQ97Z79.
SMRiQ97Z79. Positions 1-266.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97Z79.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8372S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eIF-2-alpha family.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04107. Archaea.
COG1093. LUCA.
HOGENOMiHOG000224965.
InParanoidiQ97Z79.
KOiK03237.
OMAiWYLEEQF.

Family and domain databases

Gene3Di1.10.150.190. 1 hit.
2.40.50.140. 1 hit.
3.30.70.1130. 1 hit.
HAMAPiMF_00231. eIF_2_alpha. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR022964. TIF2_asu_arc.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle.
IPR011488. TIF_2_asu.
[Graphical view]
PfamiPF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97Z79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYSRSKLPS EGEILIATVK QVFDYGSYVS LDEYGGLQAF LPWSEVSSKW
60 70 80 90 100
VKNIRDVLKE NRKVIVKVIR VDRRKGTVDV SLKKVTDDER RKKNLQWKKI
110 120 130 140 150
QRLDKILELV SQKLKLSEKD AWEQVAWKLE AKYGDPITAI EKAVKEGEKI
160 170 180 190 200
LIDAGVPEIW VKPLLEEASK HAEERKVKMS GLITVRTNEP LGVEKIKEVI
210 220 230 240 250
SKALENIEQD YESLLNIKIY TIGAPRYRVD VVGTNPKEAS EALNQIISNL
260
IKIGKEENVD ISVVKK
Length:266
Mass (Da):30,382
Last modified:October 1, 2001 - v1
Checksum:iA94E66BBE2931272
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41314.1.
PIRiC90257.
RefSeqiWP_009989173.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK41314; AAK41314; SSO1050.
GeneIDi27427365.
KEGGisso:SSO1050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK41314.1.
PIRiC90257.
RefSeqiWP_009989173.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AHOX-ray3.00B1-266[»]
2QMUX-ray3.20B175-266[»]
2QN6X-ray2.15B175-265[»]
3CW2X-ray2.80C/D/G/H1-266[»]
3QSYX-ray3.20B176-264[»]
3V11X-ray5.00B1-266[»]
ProteinModelPortaliQ97Z79.
SMRiQ97Z79. Positions 1-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29030N.
STRINGi273057.SSO1050.

Protocols and materials databases

DNASUi1454093.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK41314; AAK41314; SSO1050.
GeneIDi27427365.
KEGGisso:SSO1050.

Phylogenomic databases

eggNOGiarCOG04107. Archaea.
COG1093. LUCA.
HOGENOMiHOG000224965.
InParanoidiQ97Z79.
KOiK03237.
OMAiWYLEEQF.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-997-MONOMER.
BRENDAi3.6.5.3. 6163.

Miscellaneous databases

EvolutionaryTraceiQ97Z79.

Family and domain databases

Gene3Di1.10.150.190. 1 hit.
2.40.50.140. 1 hit.
3.30.70.1130. 1 hit.
HAMAPiMF_00231. eIF_2_alpha. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR022964. TIF2_asu_arc.
IPR024055. TIF2_asu_C.
IPR024054. TIF2_asu_middle.
IPR011488. TIF_2_asu.
[Graphical view]
PfamiPF07541. EIF_2_alpha. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF110993. SSF110993. 1 hit.
SSF116742. SSF116742. 1 hit.
SSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2A_SULSO
AccessioniPrimary (citable) accession number: Q97Z79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2001
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.