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Protein

CRISPR-associated endoribonuclease Cas2 2

Gene

cas22

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).By similarity1 Publication

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi8 – 81Magnesium; catalyticSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Antiviral defense

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CRISPR-associated endoribonuclease Cas2 2 (EC:3.1.-.-)
Gene namesi
Name:cas22
Ordered Locus Names:SSO8090
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8888CRISPR-associated endoribonuclease Cas2 2PRO_0000416952Add
BLAST

Interactioni

Subunit structurei

Homodimer, forms a heterotetramer with a Cas1 homodimer.By similarity

Structurei

Secondary structure

1
88
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87Combined sources
Helixi12 – 2413Combined sources
Beta strandi28 – 314Combined sources
Beta strandi34 – 385Combined sources
Helixi44 – 5411Combined sources
Turni57 – 593Combined sources
Beta strandi61 – 677Combined sources
Helixi69 – 735Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EXCX-ray2.25X1-88[»]
ProteinModelPortaliQ97Y85.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97Y85.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ97Y85.
OMAiSEVEWAN.

Family and domain databases

Gene3Di3.30.70.240. 1 hit.
HAMAPiMF_01471. Cas2. 1 hit.
InterProiIPR021127. CRISPR_associated_Cas2.
IPR000640. EFG_V.
IPR019199. Virulence_VapD/CRISPR_Cas2.
[Graphical view]
PfamiPF09827. CRISPR_Cas2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01573. cas2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97Y85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLVVYDVS DDSKRNKLAN NLKKLGLERI QRSAFEGDID SQRVKDLVRV
60 70 80
VKLIVDTNTD IVHIIPLGIR DWERRIVIGR EGLEEWLV
Length:88
Mass (Da):10,224
Last modified:October 1, 2001 - v1
Checksum:i870148D1138A7930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK54438.1.
RefSeqiWP_009990820.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK54438; AAK54438; SSO8090.
GeneIDi27427816.
KEGGisso:SSO8090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK54438.1.
RefSeqiWP_009990820.1. NC_002754.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EXCX-ray2.25X1-88[»]
ProteinModelPortaliQ97Y85.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK54438; AAK54438; SSO8090.
GeneIDi27427816.
KEGGisso:SSO8090.

Phylogenomic databases

InParanoidiQ97Y85.
OMAiSEVEWAN.

Miscellaneous databases

EvolutionaryTraceiQ97Y85.

Family and domain databases

Gene3Di3.30.70.240. 1 hit.
HAMAPiMF_01471. Cas2. 1 hit.
InterProiIPR021127. CRISPR_associated_Cas2.
IPR000640. EFG_V.
IPR019199. Virulence_VapD/CRISPR_Cas2.
[Graphical view]
PfamiPF09827. CRISPR_Cas2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01573. cas2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAS2B_SULSO
AccessioniPrimary (citable) accession number: Q97Y85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: October 1, 2001
Last modified: July 6, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.