Q97XW1 (GLPK1_SULSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase 1
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase 1
Glycerokinase 1
Short name=GK 1

Gene names

Name:	glpK1
Ordered Locus Names:	SSO1600

Organism

Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

Taxonomic identifier

273057 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Glycerol kinase 1 HAMAP MF_00186		PRO_0000059533
Regions
	Nucleotide binding	408 – 412	5	ATP By similarity
Sites
	Binding site	16	1	Substrate By similarity
	Binding site	20	1	ATP By similarity
	Binding site	84	1	Substrate By similarity
	Binding site	135	1	Substrate By similarity
	Binding site	242	1	Substrate By similarity
	Binding site	264	1	ATP By similarity
	Binding site	307	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q97XW1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 3A27B3EF44371E88	FASTA	501	55,681
	10 20 30 40 50 60 MNTMSHKFVL ALDEGTTSAR AILFDSDLNI VNIGQYEFPQ YYPQPGYVEH DPEEIWEAQM 70 80 90 100 110 120 LAVKKAISKI DAKQIVAIGI TNQRETTVLW DAKSGKPVYN AIVWQDRRTS PITDWLKANY 130 140 150 160 170 180 FKMIKDKTGL VPDPYFSASK IKWILDNVPN VREKAERGEI KFGTLDTYLI WRLTNGKAHV 190 200 210 220 230 240 TDYSNASRTM LFNINKLECD REILELLKIP ESILPEVKPS SEIYGYSEAL GNLIPISGDA 250 260 270 280 290 300 GDQQAALFGQ VAFNVGEIKA TYGTGSFILM NIGNNPIRSE NLLTTIAWGL EKNKATYALE 310 320 330 340 350 360 GSIFITGAAV QWFRDGLRAI DVSDEIEPLA SNVEDNGGVY FVPAFVGLGA PYWDPYARGL 370 380 390 400 410 420 IIGITRGTTK AHIARAILES MAYQTRDVIE VMQKESGISI NSLKVDGGAA KDNLLMQFQA 430 440 450 460 470 480 DILGIKVIRP KVMETTSMGV AMLAGLGVGL WNSLEELRSI WKVDKEFIPS MSEEKRRALY 490 500 SGWKEAVKRA MGWAKVVGGQ V

References

[1]

"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006641 Genomic DNA. Translation: AAK41808.1.
PIR	A99319.
RefSeq	NP_343018.1. NC_002754.1.
3D structure databases
ProteinModelPortal	Q97XW1.
SMR	Q97XW1. Positions 7-497.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1454587.
GenomeReviews	Gene locus SSO1600 in contig AE006641_GR.
KEGG	sso:SSO1600.
NMPDR	fig|273057.1.peg.1441.
Phylogenomic databases
HOGENOM	HBG511469.
OMA	FHWSINA.
ProtClustDB	CLSK268256.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO1600-MONOMER.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK1_SULSO

Accession

Primary (citable) accession number: Q97XW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	October 1, 2001
Last modified:	December 14, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program