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Q97WJ8 (NADK_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:SSO2219
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 249249NAD kinase HAMAP-Rule MF_00361
PRO_0000120709

Regions

Nucleotide binding45 – 462NAD By similarity
Nucleotide binding110 – 1112NAD By similarity
Nucleotide binding149 – 1546NAD By similarity

Sites

Active site451Proton acceptor By similarity
Binding site501NAD By similarity
Binding site1381NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97WJ8 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: D4AD6A9F7DCD8A49

FASTA24927,890
        10         20         30         40         50         60 
MRVKIVSKPT SQLNYTVEKI KNISNKLGFE VVDIDFDYVI AVGGDGTLLR AVKLGKPVIA 

        70         80         90        100        110        120 
IKAGRRGLLM DVPVDKIEDA LLRLKKGDYN EEEYMLLEMV HNDKVELGFN EIGILYDRPE 

       130        140        150        160        170        180 
AIKVGISFDT ERVSVEGDGV LVSTPQGSSG WGMSATNSLL YKDLNAIEII FVNPIFYYLR 

       190        200        210        220        230        240 
SVVIPPKSLI LRLEDKGYPQ TARVVVDGEV VTLIKTNQEI TVRVSQHKAK ILRFFKLDLI 


GEVLHAYHI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK42388.1.
PIRE90391.
RefSeqNP_343598.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ97WJ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO2219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK42388; AAK42388; SSO2219.
GeneID1453715.
KEGGsso:SSO2219.

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000270621.
KOK00858.
OMAFPRENFL.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-2073-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_SULSO
AccessionPrimary (citable) accession number: Q97WJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 1, 2001
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families