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Q97WE5

- PGMI_SULSO

UniProt

Q97WE5 - PGMI_SULSO

Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

SSO2281

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.
    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei192 – 1921Proton acceptorBy similarity
    Active sitei208 – 2081Proton donorBy similarity
    Active sitei286 – 2861Proton acceptorCurated

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
    2. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-2128-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional phosphoglucose/phosphomannose isomerase
    Alternative name(s):
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Ordered Locus Names:SSO2281
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Bifunctional phosphoglucose/phosphomannose isomerasePRO_0000227796Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi273057.SSO2281.

    Structurei

    3D structure databases

    ProteinModelPortaliQ97WE5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PGI/PMI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000270998.
    KOiK15916.
    OMAiNWIEGSE.

    Family and domain databases

    InterProiIPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    [Graphical view]
    PfamiPF10432. bact-PGI_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q97WE5-1 [UniParc]FASTAAdd to Basket

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    MDEIYLNWDK MFDEAFRIPI HEIKNDNIVF SGIGGSGIVG EIANILGVEL    50
    SFKRKFTGKE SLIAVSYSGT TSETINDVEN AVKAGSEVII ITSGGILEKL 100
    AKEKSLKLIK IPSGFQTRYA FPYLFTPLIK MTTKRRGIKI NEMELKEGVI 150
    EAKEQIKADA TRLAELLINR IPVIYSSKYL AIAKRFKQEI NENAKHPAFY 200
    GEIPEINHNE IESYVHGPSL VSVIVESSEI DKITEDVLNS IVIKPYFNSD 250
    EKNISSLLAL AGVTSLEMAK KLNEKPDKLY NIPKARQLTS NLFKIN 296
    Length:296
    Mass (Da):33,141
    Last modified:October 1, 2001 - v1
    Checksum:iE4EA89F3BA2F215B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK42443.1.
    PIRiD90398.
    RefSeqiNP_343653.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK42443; AAK42443; SSO2281.
    GeneIDi1453770.
    KEGGisso:SSO2281.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK42443.1 .
    PIRi D90398.
    RefSeqi NP_343653.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali Q97WE5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO2281.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK42443 ; AAK42443 ; SSO2281 .
    GeneIDi 1453770.
    KEGGi sso:SSO2281.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000270998.
    KOi K15916.
    OMAi NWIEGSE.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-2128-MONOMER.

    Family and domain databases

    InterProi IPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    [Graphical view ]
    Pfami PF10432. bact-PGI_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiPGMI_SULSO
    AccessioniPrimary (citable) accession number: Q97WE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3