Reviewed, UniProtKB/Swiss-Prot Q97WE5 (PGMI_SULSO)

Names and origin

Protein names

Recommended name:
    Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
    Phosphoglucose isomerase
      Short name=PGI
    Mannose-6-phosphate isomerase
    EC=5.3.1.8
    Phosphomannose isomerase
      Short name=PMI

Gene names

Ordered Locus Names:

SSO2281

Organism

Sulfolobus solfataricus [Complete proteome] [HAMAP]

Taxonomic identifier

2287 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.
Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. D-mannose 6-phosphate = D-fructose 6-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the PGI/PMI family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Bifunctional phosphoglucose/phosphomannose isomerase		PRO_0000227796
Sites
	Active site	192	1	Proton acceptor By similarity
	Active site	208	1	Proton donor By similarity
	Active site	286	1	Proton acceptor Probable

Sequences

	Sequence		Length	Mass (Da)
	Q97WE5-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: E4EA89F3BA2F215B	FASTA	296	33,141
	10 20 30 40 50 60 MDEIYLNWDK MFDEAFRIPI HEIKNDNIVF SGIGGSGIVG EIANILGVEL SFKRKFTGKE 70 80 90 100 110 120 SLIAVSYSGT TSETINDVEN AVKAGSEVII ITSGGILEKL AKEKSLKLIK IPSGFQTRYA 130 140 150 160 170 180 FPYLFTPLIK MTTKRRGIKI NEMELKEGVI EAKEQIKADA TRLAELLINR IPVIYSSKYL 190 200 210 220 230 240 AIAKRFKQEI NENAKHPAFY GEIPEINHNE IESYVHGPSL VSVIVESSEI DKITEDVLNS 250 260 270 280 290 IVIKPYFNSD EKNISSLLAL AGVTSLEMAK KLNEKPDKLY NIPKARQLTS NLFKIN

References

[1]

"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006641 Genomic DNA. Translation: AAK42443.1.
PIR	D90398.
RefSeq	NP_343653.1.
3D structure databases
SMR	Q97WE5. Positions 1-287.
ModBase	Search...
Genome annotation databases
GeneID	1453770.
GenomeReviews	Gene locus SSO2281 in contig AE006641_GR.
KEGG	sso:SSO2281.
NMPDR	fig|273057.1.peg.2076.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553399.
OMA	AYRVKNE.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO2281-MONOMER.
BRENDA	5.3.1.8. 2070. 5.3.1.9. 2070.
Family and domain databases
InterPro	IPR011857. Glu6P/Mann6P_isomerase. IPR019490. Glu6P/Mann6P_isomerase_C. [Graphical view]
Pfam	PF10432. bact-PGI_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR02128. G6PI_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PGMI_SULSO

Accession

Primary (citable) accession number: Q97WE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	October 1, 2001
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)