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Q97WE5

- PGMI_SULSO

UniProt

Q97WE5 - PGMI_SULSO

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Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

SSO2281

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921Proton acceptorBy similarity
Active sitei208 – 2081Proton donorBy similarity
Active sitei286 – 2861Proton acceptorCurated

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-2128-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:SSO2281
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Bifunctional phosphoglucose/phosphomannose isomerasePRO_0000227796Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi273057.SSO2281.

Structurei

3D structure databases

ProteinModelPortaliQ97WE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PGI/PMI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000270998.
InParanoidiQ97WE5.
KOiK15916.
OMAiNWIEGSE.

Family and domain databases

InterProiIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
[Graphical view]
PfamiPF10432. bact-PGI_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97WE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEIYLNWDK MFDEAFRIPI HEIKNDNIVF SGIGGSGIVG EIANILGVEL
60 70 80 90 100
SFKRKFTGKE SLIAVSYSGT TSETINDVEN AVKAGSEVII ITSGGILEKL
110 120 130 140 150
AKEKSLKLIK IPSGFQTRYA FPYLFTPLIK MTTKRRGIKI NEMELKEGVI
160 170 180 190 200
EAKEQIKADA TRLAELLINR IPVIYSSKYL AIAKRFKQEI NENAKHPAFY
210 220 230 240 250
GEIPEINHNE IESYVHGPSL VSVIVESSEI DKITEDVLNS IVIKPYFNSD
260 270 280 290
EKNISSLLAL AGVTSLEMAK KLNEKPDKLY NIPKARQLTS NLFKIN
Length:296
Mass (Da):33,141
Last modified:October 1, 2001 - v1
Checksum:iE4EA89F3BA2F215B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK42443.1.
PIRiD90398.
RefSeqiNP_343653.1. NC_002754.1.
WP_009991835.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42443; AAK42443; SSO2281.
GeneIDi1453770.
KEGGisso:SSO2281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK42443.1 .
PIRi D90398.
RefSeqi NP_343653.1. NC_002754.1.
WP_009991835.1. NC_002754.1.

3D structure databases

ProteinModelPortali Q97WE5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO2281.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK42443 ; AAK42443 ; SSO2281 .
GeneIDi 1453770.
KEGGi sso:SSO2281.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000270998.
InParanoidi Q97WE5.
KOi K15916.
OMAi NWIEGSE.

Enzyme and pathway databases

BioCyci SSOL273057:GCH2-2128-MONOMER.

Family and domain databases

InterProi IPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
[Graphical view ]
Pfami PF10432. bact-PGI_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiPGMI_SULSO
AccessioniPrimary (citable) accession number: Q97WE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3