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Protein

RNA 3'-terminal phosphate cyclase

Gene

rtcA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity).By similarity

Catalytic activityi

ATP + (RNA)-3'-(3'-phospho-ribonucleoside) = AMP + diphosphate + (RNA)-3'-(2',3'-cyclophospho)-ribonucleoside.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101ATPBy similarity1
Active sitei306Tele-AMP-histidine intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi282 – 285ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclase (EC:6.5.1.4)
Short name:
RNA cyclase
Short name:
RNA-3'-phosphate cyclase
Gene namesi
Name:rtcA
Ordered Locus Names:SSO2446
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564361 – 337RNA 3'-terminal phosphate cyclaseAdd BLAST337

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO2446

Structurei

3D structure databases

ProteinModelPortaliQ97W04
SMRiQ97W04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04125 Archaea
COG0430 LUCA
HOGENOMiHOG000015264
InParanoidiQ97W04
KOiK01974
OMAiANRPKPG
OrthoDBiPOG093Z05RD

Family and domain databases

Gene3Di3.30.360.20, 1 hit
3.65.10.20, 2 hits
HAMAPiMF_00200 RTC, 1 hit
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR017770 RNA3'_term_phos_cyc_type_1
IPR020719 RNA3'_term_phos_cycl-like_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF0 PTHR11096:SF0, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR03399 RNA_3prim_cycl, 1 hit
PROSITEiView protein in PROSITE
PS01287 RTC, 1 hit

Sequencei

Sequence statusi: Complete.

Q97W04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEIDGSFGE GGGQILRTSL TLSVITGKPF RIFNIRANRP NPGLQRQHLW
60 70 80 90 100
AVRAMKMISN AETKGDEVGS KELTFIPHEI KGNSIIDIDI GTAGSVTLIM
110 120 130 140 150
QTMIPAIINK NMRIKIKGGT DVPKSPTIDY IRLVYLEILR KIGIESKVNL
160 170 180 190 200
IKRGHYPEGG GEVIIENVNG NPSDFSLLEL GKLIMIKGIS HVSSLPSHIA
210 220 230 240 250
ERQKDSAKAI LSKLGVQIEI ETDVRQGEVS KGSGIALAAI GEKSIIGADS
260 270 280 290 300
LGERGKRAEI VGEEAARKLI DNLNTKAAVD VHMSDMLMIF TSLFGGEYIG
310 320 330
AELTSHAYTN MEIIRKFLDV KIEISGKRPF RFKAKIF
Length:337
Mass (Da):36,845
Last modified:May 27, 2002 - v2
Checksum:i53E7FD006751D9B0
GO

Sequence cautioni

The sequence AAK42586 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK42586.1 Different initiation.
PIRiC90416
RefSeqiWP_009993131.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK42586; AAK42586; SSO2446
GeneIDi27428746
KEGGisso:SSO2446
PATRICifig|273057.12.peg.2524

Similar proteinsi

Entry informationi

Entry nameiRTCA_SULSO
AccessioniPrimary (citable) accession number: Q97W04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: March 28, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health