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Protein

NAD-dependent protein deacetylase

Gene

cobB

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.UniRule annotation1 Publication

Catalytic activityi

NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei116 – 1161Proton acceptor
Metal bindingi124 – 1241ZincUniRule annotation
Metal bindingi127 – 1271ZincUniRule annotation
Metal bindingi149 – 1491ZincUniRule annotation
Metal bindingi151 – 1511ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 4020NADUniRule annotationAdd
BLAST
Nucleotide bindingi98 – 1014NADUniRule annotation
Nucleotide bindingi186 – 1883NADUniRule annotation
Nucleotide bindingi212 – 2143NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-2301-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD-dependent protein deacetylaseUniRule annotation (EC:3.5.1.-UniRule annotation)
Alternative name(s):
Regulatory protein SIR2 homologUniRule annotation
ssSir2
Gene namesi
Name:cobBUniRule annotation
Ordered Locus Names:SSO2478
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi116 – 1161H → Y: Loss of function. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247NAD-dependent protein deacetylasePRO_0000110388Add
BLAST

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi273057.SSO2478.

Structurei

3D structure databases

ProteinModelPortaliQ97VX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 246243Deacetylase sirtuin-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sirtuin family. Class U subfamily.UniRule annotation
Contains 1 deacetylase sirtuin-type domain.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04248. Archaea.
COG0846. LUCA.
HOGENOMiHOG000085951.
KOiK12410.
OMAiVTEFHGN.

Family and domain databases

Gene3Di3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
HAMAPiMF_01968. Sirtuin_ClassU. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR028628. Sirtuin_class_U.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97VX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYEKVAEEL ISSSYTIAFT GAGISTASGI PDFRGPQGLW KKYSPELASI
60 70 80 90 100
EYFEKDPKNF WGFYSLRMRG LFEAQPNKAH YSLAELEKMG IIKVIITQNI
110 120 130 140 150
DGLHQKAGSK NVIELHGTMR RSYCVLCLRT YDSLNVLSMI EKGNLPPRCD
160 170 180 190 200
CGGIIRPDVV LFGEPVKNIY EALSIAYESD LVISIGSSLT VYPANLIPQT
210 220 230 240
VKERGGKLII LNMEETPLDS IADYVVREPV EISLPKILEN VRQKILS
Length:247
Mass (Da):27,594
Last modified:October 1, 2001 - v1
Checksum:iA509E4132914E6AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK42615.1.
PIRiH90419.
RefSeqiWP_010923883.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42615; AAK42615; SSO2478.
GeneIDi1453942.
KEGGisso:SSO2478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK42615.1.
PIRiH90419.
RefSeqiWP_010923883.1. NC_002754.1.

3D structure databases

ProteinModelPortaliQ97VX5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO2478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK42615; AAK42615; SSO2478.
GeneIDi1453942.
KEGGisso:SSO2478.

Phylogenomic databases

eggNOGiarCOG04248. Archaea.
COG0846. LUCA.
HOGENOMiHOG000085951.
KOiK12410.
OMAiVTEFHGN.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-2301-MONOMER.

Family and domain databases

Gene3Di3.30.1600.10. 2 hits.
3.40.50.1220. 3 hits.
HAMAPiMF_01968. Sirtuin_ClassU. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026591. Sirtuin_cat_small_dom.
IPR028628. Sirtuin_class_U.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 1 hit.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPD_SULSO
AccessioniPrimary (citable) accession number: Q97VX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2001
Last modified: November 11, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.