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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87SubstrateUniRule annotation1
Metal bindingi218ManganeseUniRule annotation1
Metal bindingi237Manganese; via tele nitrogenUniRule annotation1
Binding sitei258SubstrateUniRule annotation1
Active sitei260UniRule annotation1
Metal bindingi275ManganeseUniRule annotation1
Binding sitei367GTPUniRule annotation1
Binding sitei398GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi259 – 264GTPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.1.1.32 6163
UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:SSO2537
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001036221 – 603Phosphoenolpyruvate carboxykinase [GTP]Add BLAST603

Proteomic databases

PRIDEiQ97VS5

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO2537

Structurei

3D structure databases

ProteinModelPortaliQ97VS5
SMRiQ97VS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 211Substrate bindingUniRule annotation3
Regioni365 – 367Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG05865 Archaea
COG1274 LUCA
HOGENOMiHOG000191700
InParanoidiQ97VS5
KOiK01596
OMAiCWLALTD
OrthoDBiPOG093Z01SN

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit

Sequencei

Sequence statusi: Complete.

Q97VS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSSLDFLNN FIQRDAVKKL ESINNYPLIE FLNSVVKLCE PDSVYLITGS
60 70 80 90 100
DEEKEYIRKK ALESKEEIRL QTSGHTIHFD HPLDQARARE DTFILSDTKI
110 120 130 140 150
PYVNTKPRNE GLSEMLTLLK GSMRGREMYV GFYSLGPRNS PFQILAVQVT
160 170 180 190 200
DSPYVIHSEN ILYRIAFEDF SNNTKFLRFV HSKGEPDIKK RRIMIDLANN
210 220 230 240 250
TVYSVNTTYA GNSVGLKKLA LRLTIMKAVE EGWLSEHMAI VGFNGDKGIH
260 270 280 290 300
YFTASFPSGS GKTSTSMIGN LISDDLAFIR EFEGLPKAVN PEIGVFGIIQ
310 320 330 340 350
GINARDDPII WEVLHKPGEV IFSNVLMTED GDVYWEGSEL PKPERGYNHE
360 370 380 390 400
GRWDRESGKP ASHPNARFTV PLTSFSNLDK NWDNPNGVII DGIIFGVRDY
410 420 430 440 450
STLVPVVEAF SWSHGVITIG ASMESARTSA VIGKSDELEF NPMAILDFMP
460 470 480 490 500
ISLSRYLRNY LNFGKRLRKS PKIFGFNYFL KDDNKFLNSK EDKKVWVSWA
510 520 530 540 550
VKRVEETANA IYTPIGLIPF YEDLKALFKR VLGKEYGKEE YEKQFTIKLR
560 570 580 590 600
KYLEKTERII EIYLKFEDIP SEVINELKMQ KERIVDYINK YGDSVSPFRL

EKD
Length:603
Mass (Da):69,057
Last modified:September 26, 2001 - v1
Checksum:iDA4CE81C0BA84F13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK42666.1
PIRiC90426
RefSeqiWP_009990986.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK42666; AAK42666; SSO2537
GeneIDi27428835
KEGGisso:SSO2537
PATRICifig|273057.12.peg.2613

Similar proteinsi

Entry informationi

Entry nameiPCKG_SULSO
AccessioniPrimary (citable) accession number: Q97VS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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