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Q97VS5

- PCKG_SULSO

UniProt

Q97VS5 - PCKG_SULSO

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (26 Sep 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871SubstrateUniRule annotation
    Binding sitei211 – 2111Substrate; via amide nitrogenUniRule annotation
    Metal bindingi218 – 2181ManganeseUniRule annotation
    Binding sitei218 – 2181SubstrateUniRule annotation
    Metal bindingi237 – 2371Manganese; via tele nitrogenUniRule annotation
    Binding sitei258 – 2581SubstrateUniRule annotation
    Active sitei260 – 2601UniRule annotation
    Metal bindingi275 – 2751ManganeseUniRule annotation
    Binding sitei367 – 3671GTPUniRule annotation
    Binding sitei398 – 3981GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-2352-MONOMER.
    BRENDAi4.1.1.32. 6163.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:SSO2537
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 603603Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103622Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273057.SSO2537.

    Structurei

    3D structure databases

    ProteinModelPortaliQ97VS5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni365 – 3673Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiRIASKMA.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q97VS5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSSLDFLNN FIQRDAVKKL ESINNYPLIE FLNSVVKLCE PDSVYLITGS    50
    DEEKEYIRKK ALESKEEIRL QTSGHTIHFD HPLDQARARE DTFILSDTKI 100
    PYVNTKPRNE GLSEMLTLLK GSMRGREMYV GFYSLGPRNS PFQILAVQVT 150
    DSPYVIHSEN ILYRIAFEDF SNNTKFLRFV HSKGEPDIKK RRIMIDLANN 200
    TVYSVNTTYA GNSVGLKKLA LRLTIMKAVE EGWLSEHMAI VGFNGDKGIH 250
    YFTASFPSGS GKTSTSMIGN LISDDLAFIR EFEGLPKAVN PEIGVFGIIQ 300
    GINARDDPII WEVLHKPGEV IFSNVLMTED GDVYWEGSEL PKPERGYNHE 350
    GRWDRESGKP ASHPNARFTV PLTSFSNLDK NWDNPNGVII DGIIFGVRDY 400
    STLVPVVEAF SWSHGVITIG ASMESARTSA VIGKSDELEF NPMAILDFMP 450
    ISLSRYLRNY LNFGKRLRKS PKIFGFNYFL KDDNKFLNSK EDKKVWVSWA 500
    VKRVEETANA IYTPIGLIPF YEDLKALFKR VLGKEYGKEE YEKQFTIKLR 550
    KYLEKTERII EIYLKFEDIP SEVINELKMQ KERIVDYINK YGDSVSPFRL 600
    EKD 603
    Length:603
    Mass (Da):69,057
    Last modified:September 26, 2001 - v1
    Checksum:iDA4CE81C0BA84F13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK42666.1.
    PIRiC90426.
    RefSeqiNP_343876.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK42666; AAK42666; SSO2537.
    GeneIDi1453993.
    KEGGisso:SSO2537.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK42666.1 .
    PIRi C90426.
    RefSeqi NP_343876.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali Q97VS5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO2537.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK42666 ; AAK42666 ; SSO2537 .
    GeneIDi 1453993.
    KEGGi sso:SSO2537.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi RIASKMA.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci SSOL273057:GCH2-2352-MONOMER.
    BRENDAi 4.1.1.32. 6163.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiPCKG_SULSO
    AccessioniPrimary (citable) accession number: Q97VS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3