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Q97VS5

- PCKG_SULSO

UniProt

Q97VS5 - PCKG_SULSO

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, SSO2537
Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871Substrate By similarity
Binding sitei211 – 2111Substrate; via amide nitrogen By similarity
Metal bindingi218 – 2181Manganese By similarity
Binding sitei218 – 2181Substrate By similarity
Metal bindingi237 – 2371Manganese; via tele nitrogen By similarity
Binding sitei258 – 2581Substrate By similarity
Active sitei260 – 2601 By similarity
Metal bindingi275 – 2751Manganese By similarity
Binding sitei367 – 3671GTP By similarity
Binding sitei398 – 3981GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-2352-MONOMER.
BRENDAi4.1.1.32. 6163.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:SSO2537
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 603603Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_0000103622Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO2537.

Structurei

3D structure databases

ProteinModelPortaliQ97VS5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni365 – 3673Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiRIASKMA.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97VS5-1 [UniParc]FASTAAdd to Basket

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MKSSLDFLNN FIQRDAVKKL ESINNYPLIE FLNSVVKLCE PDSVYLITGS    50
DEEKEYIRKK ALESKEEIRL QTSGHTIHFD HPLDQARARE DTFILSDTKI 100
PYVNTKPRNE GLSEMLTLLK GSMRGREMYV GFYSLGPRNS PFQILAVQVT 150
DSPYVIHSEN ILYRIAFEDF SNNTKFLRFV HSKGEPDIKK RRIMIDLANN 200
TVYSVNTTYA GNSVGLKKLA LRLTIMKAVE EGWLSEHMAI VGFNGDKGIH 250
YFTASFPSGS GKTSTSMIGN LISDDLAFIR EFEGLPKAVN PEIGVFGIIQ 300
GINARDDPII WEVLHKPGEV IFSNVLMTED GDVYWEGSEL PKPERGYNHE 350
GRWDRESGKP ASHPNARFTV PLTSFSNLDK NWDNPNGVII DGIIFGVRDY 400
STLVPVVEAF SWSHGVITIG ASMESARTSA VIGKSDELEF NPMAILDFMP 450
ISLSRYLRNY LNFGKRLRKS PKIFGFNYFL KDDNKFLNSK EDKKVWVSWA 500
VKRVEETANA IYTPIGLIPF YEDLKALFKR VLGKEYGKEE YEKQFTIKLR 550
KYLEKTERII EIYLKFEDIP SEVINELKMQ KERIVDYINK YGDSVSPFRL 600
EKD 603
Length:603
Mass (Da):69,057
Last modified:September 26, 2001 - v1
Checksum:iDA4CE81C0BA84F13
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006641 Genomic DNA. Translation: AAK42666.1.
PIRiC90426.
RefSeqiNP_343876.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42666; AAK42666; SSO2537.
GeneIDi1453993.
KEGGisso:SSO2537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE006641 Genomic DNA. Translation: AAK42666.1 .
PIRi C90426.
RefSeqi NP_343876.1. NC_002754.1.

3D structure databases

ProteinModelPortali Q97VS5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273057.SSO2537.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK42666 ; AAK42666 ; SSO2537 .
GeneIDi 1453993.
KEGGi sso:SSO2537.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi RIASKMA.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci SSOL273057:GCH2-2352-MONOMER.
BRENDAi 4.1.1.32. 6163.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiPCKG_SULSO
AccessioniPrimary (citable) accession number: Q97VS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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